Decarboxylative acylation of indolines with α-keto acids under palladium catalysis: A facile strategy for the synthesis of 7-substituted indoles

Minyoung Kim; Neeraj Kumar Mishra; Jihye Park; Sangil Han; Youngmi Shin; Satyasheel Sharma; Youngil Lee; Eui Kyung Lee; Jong Hwan Kwak; In Su Kim

doi:10.1039/c4cc06929c

Decarboxylative acylation of indolines with α-keto acids under palladium catalysis: A facile strategy for the synthesis of 7-substituted indoles

Minyoung Kim
, Neeraj Kumar Mishra
, Jihye Park
, Sangil Han
, Youngmi Shin
, Satyasheel Sharma
, Youngil Lee
, Eui Kyung Lee
, Jong Hwan Kwak
, In Su Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

Palladium-catalyzed decarboxylative acylation of highly substituted indolines with α-keto acids via C–H bond activation is described. This protocol provides efficient access to C7-carbonylated indoles known to have diverse biological profiles.

Original language	English
Pages (from-to)	14249-14252
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	91
DOIs	https://doi.org/10.1039/c4cc06929c
State	Published - 21 Oct 2014

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10.1039/c4cc06929c

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title = "Decarboxylative acylation of indolines with α-keto acids under palladium catalysis: A facile strategy for the synthesis of 7-substituted indoles",

abstract = "Palladium-catalyzed decarboxylative acylation of highly substituted indolines with α-keto acids via C–H bond activation is described. This protocol provides efficient access to C7-carbonylated indoles known to have diverse biological profiles.",

author = "Minyoung Kim and Mishra, \{Neeraj Kumar\} and Jihye Park and Sangil Han and Youngmi Shin and Satyasheel Sharma and Youngil Lee and Lee, \{Eui Kyung\} and Kwak, \{Jong Hwan\} and Kim, \{In Su\}",

year = "2014",

month = oct,

day = "21",

doi = "10.1039/c4cc06929c",

language = "English",

volume = "50",

pages = "14249--14252",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "91",

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TY - JOUR

T1 - Decarboxylative acylation of indolines with α-keto acids under palladium catalysis

T2 - A facile strategy for the synthesis of 7-substituted indoles

AU - Kim, Minyoung

AU - Mishra, Neeraj Kumar

AU - Park, Jihye

AU - Han, Sangil

AU - Shin, Youngmi

AU - Sharma, Satyasheel

AU - Lee, Youngil

AU - Lee, Eui Kyung

AU - Kwak, Jong Hwan

AU - Kim, In Su

PY - 2014/10/21

Y1 - 2014/10/21

N2 - Palladium-catalyzed decarboxylative acylation of highly substituted indolines with α-keto acids via C–H bond activation is described. This protocol provides efficient access to C7-carbonylated indoles known to have diverse biological profiles.

AB - Palladium-catalyzed decarboxylative acylation of highly substituted indolines with α-keto acids via C–H bond activation is described. This protocol provides efficient access to C7-carbonylated indoles known to have diverse biological profiles.

UR - https://www.scopus.com/pages/publications/84908334649

U2 - 10.1039/c4cc06929c

DO - 10.1039/c4cc06929c

M3 - Article

C2 - 25284736

AN - SCOPUS:84908334649

SN - 1359-7345

VL - 50

SP - 14249

EP - 14252

JO - Chemical Communications

JF - Chemical Communications

IS - 91

ER -

Decarboxylative acylation of indolines with α-keto acids under palladium catalysis: A facile strategy for the synthesis of 7-substituted indoles

Abstract

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