Cytomegalovirus endotheliitis after fluocinolone acetonide (Retisert) implant in a patient with Behçet Uveitis

Un Chul Park; Sang Jin Kim; Hyeong Gon Yu

doi:10.3109/09273948.2011.580075

Cytomegalovirus endotheliitis after fluocinolone acetonide (Retisert) implant in a patient with Behçet Uveitis

Un Chul Park
, Sang Jin Kim
, Hyeong Gon Yu

Seoul National University

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Purpose: To report a case of cytomegalovirus (CMV) endotheliitis after insertion of an intravitreal fluocinolone acetonide (Retisert) implant. Design: Interventional case report. Methods: Retrospective chart review. Results: A 40-year-old man received a Retisert implant in the left eye for recurrent Behçet uveitis. Although inflammation became quiescent within a month, corneal edema developed 4 months after insertion. Polymerase chain reaction analysis for aqueous humor detected 3.9×10⁴ copies/mL of CMV DNA. After treatment with oral valganciclovir, CMV DNA nearly disappeared but visual outcome was poor due to corneal decompensation resulting from severe endothelial cell loss. Conclusions: After Retisert implant, clinicians should be attentive to the potential risk of CMV endotheliitis.

Original language	English
Pages (from-to)	282-283
Number of pages	2
Journal	Ocular Immunology and Inflammation
Volume	19
Issue number	4
DOIs	https://doi.org/10.3109/09273948.2011.580075
State	Published - Aug 2011
Externally published	Yes

Keywords

Behcet's uveitis
cytomegalovirus endotheliitis
fluocinolone acetonide

Access to Document

10.3109/09273948.2011.580075

Cite this

@article{a638bf2b1915485f898a204dc52571aa,

title = "Cytomegalovirus endotheliitis after fluocinolone acetonide (Retisert) implant in a patient with Beh{\c c}et Uveitis",

abstract = "Purpose: To report a case of cytomegalovirus (CMV) endotheliitis after insertion of an intravitreal fluocinolone acetonide (Retisert) implant. Design: Interventional case report. Methods: Retrospective chart review. Results: A 40-year-old man received a Retisert implant in the left eye for recurrent Beh{\c c}et uveitis. Although inflammation became quiescent within a month, corneal edema developed 4 months after insertion. Polymerase chain reaction analysis for aqueous humor detected 3.9×104 copies/mL of CMV DNA. After treatment with oral valganciclovir, CMV DNA nearly disappeared but visual outcome was poor due to corneal decompensation resulting from severe endothelial cell loss. Conclusions: After Retisert implant, clinicians should be attentive to the potential risk of CMV endotheliitis.",

keywords = "Behcet's uveitis, cytomegalovirus endotheliitis, fluocinolone acetonide",

author = "Park, \{Un Chul\} and Kim, \{Sang Jin\} and Yu, \{Hyeong Gon\}",

year = "2011",

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doi = "10.3109/09273948.2011.580075",

language = "English",

volume = "19",

pages = "282--283",

journal = "Ocular Immunology and Inflammation",

issn = "0927-3948",

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T1 - Cytomegalovirus endotheliitis after fluocinolone acetonide (Retisert) implant in a patient with Behçet Uveitis

AU - Park, Un Chul

AU - Kim, Sang Jin

AU - Yu, Hyeong Gon

PY - 2011/8

Y1 - 2011/8

N2 - Purpose: To report a case of cytomegalovirus (CMV) endotheliitis after insertion of an intravitreal fluocinolone acetonide (Retisert) implant. Design: Interventional case report. Methods: Retrospective chart review. Results: A 40-year-old man received a Retisert implant in the left eye for recurrent Behçet uveitis. Although inflammation became quiescent within a month, corneal edema developed 4 months after insertion. Polymerase chain reaction analysis for aqueous humor detected 3.9×104 copies/mL of CMV DNA. After treatment with oral valganciclovir, CMV DNA nearly disappeared but visual outcome was poor due to corneal decompensation resulting from severe endothelial cell loss. Conclusions: After Retisert implant, clinicians should be attentive to the potential risk of CMV endotheliitis.

AB - Purpose: To report a case of cytomegalovirus (CMV) endotheliitis after insertion of an intravitreal fluocinolone acetonide (Retisert) implant. Design: Interventional case report. Methods: Retrospective chart review. Results: A 40-year-old man received a Retisert implant in the left eye for recurrent Behçet uveitis. Although inflammation became quiescent within a month, corneal edema developed 4 months after insertion. Polymerase chain reaction analysis for aqueous humor detected 3.9×104 copies/mL of CMV DNA. After treatment with oral valganciclovir, CMV DNA nearly disappeared but visual outcome was poor due to corneal decompensation resulting from severe endothelial cell loss. Conclusions: After Retisert implant, clinicians should be attentive to the potential risk of CMV endotheliitis.

KW - Behcet's uveitis

KW - cytomegalovirus endotheliitis

KW - fluocinolone acetonide

UR - https://www.scopus.com/pages/publications/79960662879

U2 - 10.3109/09273948.2011.580075

DO - 10.3109/09273948.2011.580075

M3 - Review article

C2 - 21770807

AN - SCOPUS:79960662879

SN - 0927-3948

VL - 19

SP - 282

EP - 283

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

IS - 4

ER -

Cytomegalovirus endotheliitis after fluocinolone acetonide (Retisert) implant in a patient with Behçet Uveitis

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Keywords

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