Current smoking is associated with a poor visual acuity improvement after intravitreal ranibizumab therapy in patients with exudative age-related macular degeneration

In this study, the risk factors that may influence visual improvement after intravitreal ranibizumab (IVR) treatment for exudative age-related macular degeneration (AMD) wereexamined. From 2008 to 2012, 420 patients (448 eyes) with exudative AMD were prospectively registered at Seoul National University Hospital. From this group of patients,125 eyes were included in this study. All patients were treated with 3 consecutive IVRinjections. The visual acuity (VA) was evaluated at baseline and 1 month after the thirdranibizumab injection. To evaluate the risk factors associated with VA improvement afterIVR, patient demographic data and systemic risk factors were analyzed. Patients were divided into a poorVA improvement group and a good VA improvement group, withreference to the median visual improvement in all eyes. Among125 eyes, 66 eyes (52.8%)were included in the responder group and 59 eyes (47.2%) in the non-responder group.The medianVA improvement after 3 monthly ranibizumab injections was -0.05 logMAR.Multivariate analyses revealed that current smoking (adjusted OR, 7.540; 95% CI, 1.732-32.823) was independently associated with poor VA improvement after IVR treatment forexudative AMD. In conclusion, cigarette smoking is an independent risk factor for lower VA gains with IVR treatment for exudative AMD.