Curcumin-based electrochemical sensor of amyloid-Β oligomer for the early detection of Alzheimer's disease

Amyloid β oligomer (AβO) is a promising biomarker with potential to diagnose the Alzheimer's disease (AD). To detect the low level of AβO is highly desirable for the early diagnosis of AD. Here we describe the fabrication and sensing performance of curcumin based AβO sensor. Curcumin-Ni was electropolymerized on Ni foam substrate, and the surface resistance change of the poly(curcumin-Ni) electrode depending on AβO concentration was confirmed by electrochemical impedance spectroscopy. The impedance response of the curcumin based sensor showed a proportional relationship with the concentrations of AβO in the range from 0.001 to 5 nM. The feasibility of the sensor was verified by the detection of AβO in artificial cerebrospinal fluid. The proposed AβO sensor presents valuable information related to early diagnosis of AD.