C(sp3)-H amination of 8-methylquinolines with azodicarboxylates under Rh(III) catalysis: Cytotoxic evaluation of quinolin-8-ylmethanamines

Taejoo Jeong; Neeraj Kumar Mishra; Prasanta Dey; Hyunjung Oh; Sangil Han; Suk Hun Lee; Hyung Sik Kim; Jihye Park; In Su Kim

doi:10.1039/c7cc06670h

C(sp³)-H amination of 8-methylquinolines with azodicarboxylates under Rh(III) catalysis: Cytotoxic evaluation of quinolin-8-ylmethanamines

Taejoo Jeong
, Neeraj Kumar Mishra
, Prasanta Dey
, Hyunjung Oh
, Sangil Han
, Suk Hun Lee
, Hyung Sik Kim
, Jihye Park
, In Su Kim

Department of Pharmacy

Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The rhodium(iii)-catalyzed C(sp³)-H amination reaction of 8-methylquinolines and azodicarboxylates is described. A cationic rhodium catalyst in the presence of lithium acetate and lithium carbonate was found to be an optimal catalytic system for the construction of quinolin-8-ylmethanamine derivatives, which were evaluated for in vitro cytotoxicity against human breast adenocarcinoma cells (MCF-7) and human prostate adenocarcinoma cells (LNCaP).

Original language	English
Pages (from-to)	11197-11200
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	81
DOIs	https://doi.org/10.1039/c7cc06670h
State	Published - 2017

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title = "C(sp3)-H amination of 8-methylquinolines with azodicarboxylates under Rh(III) catalysis: Cytotoxic evaluation of quinolin-8-ylmethanamines",

abstract = "The rhodium(iii)-catalyzed C(sp3)-H amination reaction of 8-methylquinolines and azodicarboxylates is described. A cationic rhodium catalyst in the presence of lithium acetate and lithium carbonate was found to be an optimal catalytic system for the construction of quinolin-8-ylmethanamine derivatives, which were evaluated for in vitro cytotoxicity against human breast adenocarcinoma cells (MCF-7) and human prostate adenocarcinoma cells (LNCaP).",

author = "Taejoo Jeong and \{Kumar Mishra\}, Neeraj and Prasanta Dey and Hyunjung Oh and Sangil Han and \{Hun Lee\}, Suk and \{Sik Kim\}, Hyung and Jihye Park and \{Su Kim\}, In",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c7cc06670h",

language = "English",

volume = "53",

pages = "11197--11200",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "81",

}

TY - JOUR

T1 - C(sp3)-H amination of 8-methylquinolines with azodicarboxylates under Rh(III) catalysis

T2 - Cytotoxic evaluation of quinolin-8-ylmethanamines

AU - Jeong, Taejoo

AU - Kumar Mishra, Neeraj

AU - Dey, Prasanta

AU - Oh, Hyunjung

AU - Han, Sangil

AU - Hun Lee, Suk

AU - Sik Kim, Hyung

AU - Park, Jihye

AU - Su Kim, In

PY - 2017

Y1 - 2017

N2 - The rhodium(iii)-catalyzed C(sp3)-H amination reaction of 8-methylquinolines and azodicarboxylates is described. A cationic rhodium catalyst in the presence of lithium acetate and lithium carbonate was found to be an optimal catalytic system for the construction of quinolin-8-ylmethanamine derivatives, which were evaluated for in vitro cytotoxicity against human breast adenocarcinoma cells (MCF-7) and human prostate adenocarcinoma cells (LNCaP).

AB - The rhodium(iii)-catalyzed C(sp3)-H amination reaction of 8-methylquinolines and azodicarboxylates is described. A cationic rhodium catalyst in the presence of lithium acetate and lithium carbonate was found to be an optimal catalytic system for the construction of quinolin-8-ylmethanamine derivatives, which were evaluated for in vitro cytotoxicity against human breast adenocarcinoma cells (MCF-7) and human prostate adenocarcinoma cells (LNCaP).

UR - https://www.scopus.com/pages/publications/85031107191

U2 - 10.1039/c7cc06670h

DO - 10.1039/c7cc06670h

M3 - Article

C2 - 28956557

AN - SCOPUS:85031107191

SN - 1359-7345

VL - 53

SP - 11197

EP - 11200

JO - Chemical Communications

JF - Chemical Communications

IS - 81

ER -

C(sp³)-H amination of 8-methylquinolines with azodicarboxylates under Rh(III) catalysis: Cytotoxic evaluation of quinolin-8-ylmethanamines

Abstract

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