Crystal Structure of β-Arrestin 2 in Complex with CXCR7 Phosphopeptide

Kyungjin Min; Hye Jin Yoon; Ji Young Park; Mithu Baidya; Hemlata Dwivedi-Agnihotri; Jagannath Maharana; Madhu Chaturvedi; Ka Young Chung; Arun K. Shukla; Hyung Ho Lee

doi:10.1016/j.str.2020.06.002

Crystal Structure of β-Arrestin 2 in Complex with CXCR7 Phosphopeptide

Kyungjin Min
, Hye Jin Yoon
, Ji Young Park
, Mithu Baidya
, Hemlata Dwivedi-Agnihotri
, Jagannath Maharana
, Madhu Chaturvedi
, Ka Young Chung
, Arun K. Shukla
, Hyung Ho Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

β-arrestins (βarrs) critically regulate GPCR signaling and trafficking. Min et al. present a 2.3-Å crystal structure of βarr2 in complex with a phosphopeptide (C7pp) derived from the carboxyl terminus of CXCR7, revealing that C7pp-bound βarr2 shows a relatively small inter-domain rotation compared with V₂Rpp-bound βarr1.

Original language	English
Pages (from-to)	1014-1023.e4
Journal	Structure
Volume	28
Issue number	9
DOIs	https://doi.org/10.1016/j.str.2020.06.002
State	Published - 1 Sep 2020

Keywords

CXCR7
G-protein-coupled receptors (GPCRs)
biased agonism
synthetic antibody fragments
β-arrestins

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10.1016/j.str.2020.06.002

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title = "Crystal Structure of β-Arrestin 2 in Complex with CXCR7 Phosphopeptide",

abstract = "β-arrestins (βarrs) critically regulate GPCR signaling and trafficking. Min et al. present a 2.3-{\AA} crystal structure of βarr2 in complex with a phosphopeptide (C7pp) derived from the carboxyl terminus of CXCR7, revealing that C7pp-bound βarr2 shows a relatively small inter-domain rotation compared with V2Rpp-bound βarr1.",

keywords = "CXCR7, G-protein-coupled receptors (GPCRs), biased agonism, synthetic antibody fragments, β-arrestins",

author = "Kyungjin Min and Yoon, \{Hye Jin\} and Park, \{Ji Young\} and Mithu Baidya and Hemlata Dwivedi-Agnihotri and Jagannath Maharana and Madhu Chaturvedi and Chung, \{Ka Young\} and Shukla, \{Arun K.\} and Lee, \{Hyung Ho\}",

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year = "2020",

month = sep,

day = "1",

doi = "10.1016/j.str.2020.06.002",

language = "English",

volume = "28",

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journal = "Structure",

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T1 - Crystal Structure of β-Arrestin 2 in Complex with CXCR7 Phosphopeptide

AU - Min, Kyungjin

AU - Yoon, Hye Jin

AU - Park, Ji Young

AU - Baidya, Mithu

AU - Dwivedi-Agnihotri, Hemlata

AU - Maharana, Jagannath

AU - Chaturvedi, Madhu

AU - Chung, Ka Young

AU - Shukla, Arun K.

AU - Lee, Hyung Ho

PY - 2020/9/1

Y1 - 2020/9/1

N2 - β-arrestins (βarrs) critically regulate GPCR signaling and trafficking. Min et al. present a 2.3-Å crystal structure of βarr2 in complex with a phosphopeptide (C7pp) derived from the carboxyl terminus of CXCR7, revealing that C7pp-bound βarr2 shows a relatively small inter-domain rotation compared with V2Rpp-bound βarr1.

AB - β-arrestins (βarrs) critically regulate GPCR signaling and trafficking. Min et al. present a 2.3-Å crystal structure of βarr2 in complex with a phosphopeptide (C7pp) derived from the carboxyl terminus of CXCR7, revealing that C7pp-bound βarr2 shows a relatively small inter-domain rotation compared with V2Rpp-bound βarr1.

KW - CXCR7

KW - G-protein-coupled receptors (GPCRs)

KW - biased agonism

KW - synthetic antibody fragments

KW - β-arrestins

UR - https://www.scopus.com/pages/publications/85087701575

U2 - 10.1016/j.str.2020.06.002

DO - 10.1016/j.str.2020.06.002

M3 - Article

C2 - 32579945

AN - SCOPUS:85087701575

SN - 0969-2126

VL - 28

SP - 1014-1023.e4

JO - Structure

JF - Structure

IS - 9

ER -

Crystal Structure of β-Arrestin 2 in Complex with CXCR7 Phosphopeptide

Abstract

Keywords

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