Cortical thickness abnormality in juvenile myoclonic epilepsy

W. S. Tae; S. H. Kim; E. Y. Joo; S. J. Han; I. Y. Kim; S. I. Kim; J. M. Lee; S. B. Hong

doi:10.1007/s00415-008-0745-6

Cortical thickness abnormality in juvenile myoclonic epilepsy

W. S. Tae, S. H. Kim, E. Y. Joo, S. J. Han, I. Y. Kim, S. I. Kim, J. M. Lee, S. B. Hong

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Previous studies on gray matter concentration changes in patients with juvenile myoclonic epilepsy (JME) are inconsistent. To investigate cortical abnormality in JME differently, we measured the cortical thickness in 19 JME patients and 18 normal controls. Results showed that the cortical thicknesses of superior/middle/medial frontal gyri, and superior/middle/ inferior temporal gyri were decreased in JME patients. Moreover, cortical thicknesses of precentral gyrus and medial orbital gyrus of right hemispheres were negatively correlated with disease duration. These findings suggest that JME brains have cortical gray matter atrophy in the frontal and temporal lobes.

Original language	English
Pages (from-to)	561-566
Number of pages	6
Journal	Journal of Neurology
Volume	255
Issue number	4
DOIs	https://doi.org/10.1007/s00415-008-0745-6
State	Published - Apr 2008
Externally published	Yes

Keywords

Cortical thickness
Epilepsy
Gray matter
Juvenile myoclonic epilepsy
Magnetic resonance imaging

Access to Document

10.1007/s00415-008-0745-6

Cite this

@article{68e52772efce424dbef1f8e494288195,

title = "Cortical thickness abnormality in juvenile myoclonic epilepsy",

abstract = "Previous studies on gray matter concentration changes in patients with juvenile myoclonic epilepsy (JME) are inconsistent. To investigate cortical abnormality in JME differently, we measured the cortical thickness in 19 JME patients and 18 normal controls. Results showed that the cortical thicknesses of superior/middle/medial frontal gyri, and superior/middle/ inferior temporal gyri were decreased in JME patients. Moreover, cortical thicknesses of precentral gyrus and medial orbital gyrus of right hemispheres were negatively correlated with disease duration. These findings suggest that JME brains have cortical gray matter atrophy in the frontal and temporal lobes.",

keywords = "Cortical thickness, Epilepsy, Gray matter, Juvenile myoclonic epilepsy, Magnetic resonance imaging",

author = "Tae, \{W. S.\} and Kim, \{S. H.\} and Joo, \{E. Y.\} and Han, \{S. J.\} and Kim, \{I. Y.\} and Kim, \{S. I.\} and Lee, \{J. M.\} and Hong, \{S. B.\}",

year = "2008",

month = apr,

doi = "10.1007/s00415-008-0745-6",

language = "English",

volume = "255",

pages = "561--566",

journal = "Journal of Neurology",

issn = "0340-5354",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "4",

}

TY - JOUR

T1 - Cortical thickness abnormality in juvenile myoclonic epilepsy

AU - Tae, W. S.

AU - Kim, S. H.

AU - Joo, E. Y.

AU - Han, S. J.

AU - Kim, I. Y.

AU - Kim, S. I.

AU - Lee, J. M.

AU - Hong, S. B.

PY - 2008/4

Y1 - 2008/4

N2 - Previous studies on gray matter concentration changes in patients with juvenile myoclonic epilepsy (JME) are inconsistent. To investigate cortical abnormality in JME differently, we measured the cortical thickness in 19 JME patients and 18 normal controls. Results showed that the cortical thicknesses of superior/middle/medial frontal gyri, and superior/middle/ inferior temporal gyri were decreased in JME patients. Moreover, cortical thicknesses of precentral gyrus and medial orbital gyrus of right hemispheres were negatively correlated with disease duration. These findings suggest that JME brains have cortical gray matter atrophy in the frontal and temporal lobes.

AB - Previous studies on gray matter concentration changes in patients with juvenile myoclonic epilepsy (JME) are inconsistent. To investigate cortical abnormality in JME differently, we measured the cortical thickness in 19 JME patients and 18 normal controls. Results showed that the cortical thicknesses of superior/middle/medial frontal gyri, and superior/middle/ inferior temporal gyri were decreased in JME patients. Moreover, cortical thicknesses of precentral gyrus and medial orbital gyrus of right hemispheres were negatively correlated with disease duration. These findings suggest that JME brains have cortical gray matter atrophy in the frontal and temporal lobes.

KW - Cortical thickness

KW - Epilepsy

KW - Gray matter

KW - Juvenile myoclonic epilepsy

KW - Magnetic resonance imaging

UR - https://www.scopus.com/pages/publications/42549161593

U2 - 10.1007/s00415-008-0745-6

DO - 10.1007/s00415-008-0745-6

M3 - Article

C2 - 18227991

AN - SCOPUS:42549161593

SN - 0340-5354

VL - 255

SP - 561

EP - 566

JO - Journal of Neurology

JF - Journal of Neurology

IS - 4

ER -

Cortical thickness abnormality in juvenile myoclonic epilepsy

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this