Coordination-driven self-assembly and anticancer activity of molecular rectangles containing octahedral ruthenium metal centers

Vaishali Vajpayee; Young Ho Song; Yoon Jung Yang; Se Chan Kang; Hyunuk Kim; In Su Kim; Ming Wang; Peter J. Stang; Ki Whan Chi

doi:10.1021/om200294x

Coordination-driven self-assembly and anticancer activity of molecular rectangles containing octahedral ruthenium metal centers

Vaishali Vajpayee
, Young Ho Song
, Yoon Jung Yang
, Se Chan Kang
, Hyunuk Kim
, In Su Kim
, Ming Wang
, Peter J. Stang
, Ki Whan Chi

University of Ulsan
University of Semyung
Pohang University of Science and Technology
University of Utah

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

The synthesis of new 2+2 metallarectangles via coordination-driven self-assembly of octahedral Ru(II)-based acceptors and amide donors is described. To evaluate their in vitro cytotoxic properties, preliminary biological assays were carried out for various human cancer cell lines, and our results show that the cytotoxicity level of 3 is comparable or even greater in the cases of SK-hep-1 and HCT-15 than that of the reference drug cisplatin.

Original language	English
Pages (from-to)	3242-3245
Number of pages	4
Journal	Organometallics
Volume	30
Issue number	12
DOIs	https://doi.org/10.1021/om200294x
State	Published - 27 Jun 2011
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1021/om200294x

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title = "Coordination-driven self-assembly and anticancer activity of molecular rectangles containing octahedral ruthenium metal centers",

abstract = "The synthesis of new 2+2 metallarectangles via coordination-driven self-assembly of octahedral Ru(II)-based acceptors and amide donors is described. To evaluate their in vitro cytotoxic properties, preliminary biological assays were carried out for various human cancer cell lines, and our results show that the cytotoxicity level of 3 is comparable or even greater in the cases of SK-hep-1 and HCT-15 than that of the reference drug cisplatin.",

author = "Vaishali Vajpayee and Song, \{Young Ho\} and Yang, \{Yoon Jung\} and Kang, \{Se Chan\} and Hyunuk Kim and Kim, \{In Su\} and Ming Wang and Stang, \{Peter J.\} and Chi, \{Ki Whan\}",

year = "2011",

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doi = "10.1021/om200294x",

language = "English",

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AU - Vajpayee, Vaishali

AU - Song, Young Ho

AU - Yang, Yoon Jung

AU - Kang, Se Chan

AU - Kim, Hyunuk

AU - Kim, In Su

AU - Wang, Ming

AU - Stang, Peter J.

AU - Chi, Ki Whan

PY - 2011/6/27

Y1 - 2011/6/27

N2 - The synthesis of new 2+2 metallarectangles via coordination-driven self-assembly of octahedral Ru(II)-based acceptors and amide donors is described. To evaluate their in vitro cytotoxic properties, preliminary biological assays were carried out for various human cancer cell lines, and our results show that the cytotoxicity level of 3 is comparable or even greater in the cases of SK-hep-1 and HCT-15 than that of the reference drug cisplatin.

AB - The synthesis of new 2+2 metallarectangles via coordination-driven self-assembly of octahedral Ru(II)-based acceptors and amide donors is described. To evaluate their in vitro cytotoxic properties, preliminary biological assays were carried out for various human cancer cell lines, and our results show that the cytotoxicity level of 3 is comparable or even greater in the cases of SK-hep-1 and HCT-15 than that of the reference drug cisplatin.

UR - https://www.scopus.com/pages/publications/79959413795

U2 - 10.1021/om200294x

DO - 10.1021/om200294x

M3 - Article

AN - SCOPUS:79959413795

SN - 0276-7333

VL - 30

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JO - Organometallics

JF - Organometallics

IS - 12

ER -

Coordination-driven self-assembly and anticancer activity of molecular rectangles containing octahedral ruthenium metal centers

Abstract

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