Considerable interindividual variation in the pharmacokinetics of tolperisone HC

J. W. Bae; M. J. Kim; Y. S. Park; C. S. Myung; C. G. Jang; S. Y. Lee

doi:10.5414/cpp45110

Considerable interindividual variation in the pharmacokinetics of tolperisone HC

J. W. Bae, M. J. Kim, Y. S. Park, C. S. Myung, C. G. Jang, S. Y. Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Objective: The aim of this study was to determine the pharmacokinetic profiles of oral tolperisone hydrochloride in healthy volunteers. Methods: After the oral administration of tolperisone hydrochloride, the plasma concentrations of tolperisone were measured in 15 healthy male Korean volunteers. The tolperisone concentration was determined using high-performance liquid chromatography with a C₁8 reverse-phase column. Results: Very large interindividual differences in the AUC and C_max were detected after oral tolperisone HCI. The AUC₀-_∞ varied from 125.9-1,241.3 ng/ml × h, and the C_max varied from 64.2 and 784.9 ng/ ml. The t_max of tolperisone was 0.90 ± 0.31 h and the mean half-life was 1.00 ± 0.28 h. Conclusion: These results suggest that the pharmacological effect of oral tolperisone HCl varies between individuals, and the oral tolperisone HCl dose might need to be individualized.

Original language	English
Pages (from-to)	110-113
Number of pages	4
Journal	International Journal of Clinical Pharmacology and Therapeutics
Volume	45
Issue number	2
DOIs	https://doi.org/10.5414/cpp45110
State	Published - Feb 2007

Keywords

Interindividual variation
Pharmacokinetics
Tolperisone

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@article{490452f7730b446296b935be73b4de24,

title = "Considerable interindividual variation in the pharmacokinetics of tolperisone HC",

abstract = "Objective: The aim of this study was to determine the pharmacokinetic profiles of oral tolperisone hydrochloride in healthy volunteers. Methods: After the oral administration of tolperisone hydrochloride, the plasma concentrations of tolperisone were measured in 15 healthy male Korean volunteers. The tolperisone concentration was determined using high-performance liquid chromatography with a C18 reverse-phase column. Results: Very large interindividual differences in the AUC and Cmax were detected after oral tolperisone HCI. The AUC0-∞ varied from 125.9-1,241.3 ng/ml × h, and the Cmax varied from 64.2 and 784.9 ng/ ml. The tmax of tolperisone was 0.90 ± 0.31 h and the mean half-life was 1.00 ± 0.28 h. Conclusion: These results suggest that the pharmacological effect of oral tolperisone HCl varies between individuals, and the oral tolperisone HCl dose might need to be individualized.",

keywords = "Interindividual variation, Pharmacokinetics, Tolperisone",

author = "Bae, \{J. W.\} and Kim, \{M. J.\} and Park, \{Y. S.\} and Myung, \{C. S.\} and Jang, \{C. G.\} and Lee, \{S. Y.\}",

year = "2007",

month = feb,

doi = "10.5414/cpp45110",

language = "English",

volume = "45",

pages = "110--113",

journal = "International Journal of Clinical Pharmacology and Therapeutics",

issn = "0946-1965",

publisher = "Dustri-Verlag Dr. Karl Feistle",

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T1 - Considerable interindividual variation in the pharmacokinetics of tolperisone HC

AU - Bae, J. W.

AU - Kim, M. J.

AU - Park, Y. S.

AU - Myung, C. S.

AU - Jang, C. G.

AU - Lee, S. Y.

PY - 2007/2

Y1 - 2007/2

N2 - Objective: The aim of this study was to determine the pharmacokinetic profiles of oral tolperisone hydrochloride in healthy volunteers. Methods: After the oral administration of tolperisone hydrochloride, the plasma concentrations of tolperisone were measured in 15 healthy male Korean volunteers. The tolperisone concentration was determined using high-performance liquid chromatography with a C18 reverse-phase column. Results: Very large interindividual differences in the AUC and Cmax were detected after oral tolperisone HCI. The AUC0-∞ varied from 125.9-1,241.3 ng/ml × h, and the Cmax varied from 64.2 and 784.9 ng/ ml. The tmax of tolperisone was 0.90 ± 0.31 h and the mean half-life was 1.00 ± 0.28 h. Conclusion: These results suggest that the pharmacological effect of oral tolperisone HCl varies between individuals, and the oral tolperisone HCl dose might need to be individualized.

AB - Objective: The aim of this study was to determine the pharmacokinetic profiles of oral tolperisone hydrochloride in healthy volunteers. Methods: After the oral administration of tolperisone hydrochloride, the plasma concentrations of tolperisone were measured in 15 healthy male Korean volunteers. The tolperisone concentration was determined using high-performance liquid chromatography with a C18 reverse-phase column. Results: Very large interindividual differences in the AUC and Cmax were detected after oral tolperisone HCI. The AUC0-∞ varied from 125.9-1,241.3 ng/ml × h, and the Cmax varied from 64.2 and 784.9 ng/ ml. The tmax of tolperisone was 0.90 ± 0.31 h and the mean half-life was 1.00 ± 0.28 h. Conclusion: These results suggest that the pharmacological effect of oral tolperisone HCl varies between individuals, and the oral tolperisone HCl dose might need to be individualized.

KW - Interindividual variation

KW - Pharmacokinetics

KW - Tolperisone

UR - https://www.scopus.com/pages/publications/33847383391

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DO - 10.5414/cpp45110

M3 - Article

C2 - 17323790

AN - SCOPUS:33847383391

SN - 0946-1965

VL - 45

SP - 110

EP - 113

JO - International Journal of Clinical Pharmacology and Therapeutics

JF - International Journal of Clinical Pharmacology and Therapeutics

IS - 2

ER -

Considerable interindividual variation in the pharmacokinetics of tolperisone HC

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Keywords

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