Conductive hydrogel/nanowire micropattern-based sensor for neural stem cell differentiation

Jong Min Lee; Joo Yoon Moon; Tae Hyun Kim; Seung Won Lee; Christian D. Ahrberg; Bong Geun Chung

doi:10.1016/j.snb.2017.11.151

Conductive hydrogel/nanowire micropattern-based sensor for neural stem cell differentiation

Jong Min Lee, Joo Yoon Moon, Tae Hyun Kim, Seung Won Lee, Christian D. Ahrberg, Bong Geun Chung

Sogang University

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

One of the main challenges regarding treatment of neurodegenerative diseases in the central nervous system (CNS) lies in the inability of neurons to undergo mitosis. Stem cell therapy could provide a possible solution to treat the neurodegenerative diseases. Here, we developed a conductive polyethylene glycol (PEG) hydrogel/silver nanowire (AgNW) composite micropattern-based sensor to direct differentiation of neuronal stem cells (NSCs) and guidance of neurite outgrowth. The ridge micropatterns made from the composite PEG hydrogel/AgNW materials were fabricated on a flexible polyethylene terephthalate (PET) film. Through the combination of these composite materials and the ridge micropatterns, the outgrowth of neurites could be efficiently guided in a controlled manner. Therefore, this conductive PEG hydrogel/AgNW micropattern-based sensor could potentially allow future use of the flexible device as an implant for NSC therapy applications.

Original language	English
Pages (from-to)	1042-1050
Number of pages	9
Journal	Sensors and Actuators, B: Chemical
Volume	258
DOIs	https://doi.org/10.1016/j.snb.2017.11.151
State	Published - 1 Apr 2018
Externally published	Yes

Keywords

Electrical stimuli
Micropattern
Nanowire
Neural stem cell differentiation
Sensor

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10.1016/j.snb.2017.11.151

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title = "Conductive hydrogel/nanowire micropattern-based sensor for neural stem cell differentiation",

abstract = "One of the main challenges regarding treatment of neurodegenerative diseases in the central nervous system (CNS) lies in the inability of neurons to undergo mitosis. Stem cell therapy could provide a possible solution to treat the neurodegenerative diseases. Here, we developed a conductive polyethylene glycol (PEG) hydrogel/silver nanowire (AgNW) composite micropattern-based sensor to direct differentiation of neuronal stem cells (NSCs) and guidance of neurite outgrowth. The ridge micropatterns made from the composite PEG hydrogel/AgNW materials were fabricated on a flexible polyethylene terephthalate (PET) film. Through the combination of these composite materials and the ridge micropatterns, the outgrowth of neurites could be efficiently guided in a controlled manner. Therefore, this conductive PEG hydrogel/AgNW micropattern-based sensor could potentially allow future use of the flexible device as an implant for NSC therapy applications.",

keywords = "Electrical stimuli, Micropattern, Nanowire, Neural stem cell differentiation, Sensor",

author = "Lee, \{Jong Min\} and Moon, \{Joo Yoon\} and Kim, \{Tae Hyun\} and Lee, \{Seung Won\} and Ahrberg, \{Christian D.\} and Chung, \{Bong Geun\}",

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doi = "10.1016/j.snb.2017.11.151",

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T1 - Conductive hydrogel/nanowire micropattern-based sensor for neural stem cell differentiation

AU - Lee, Jong Min

AU - Moon, Joo Yoon

AU - Kim, Tae Hyun

AU - Lee, Seung Won

AU - Ahrberg, Christian D.

AU - Chung, Bong Geun

PY - 2018/4/1

Y1 - 2018/4/1

N2 - One of the main challenges regarding treatment of neurodegenerative diseases in the central nervous system (CNS) lies in the inability of neurons to undergo mitosis. Stem cell therapy could provide a possible solution to treat the neurodegenerative diseases. Here, we developed a conductive polyethylene glycol (PEG) hydrogel/silver nanowire (AgNW) composite micropattern-based sensor to direct differentiation of neuronal stem cells (NSCs) and guidance of neurite outgrowth. The ridge micropatterns made from the composite PEG hydrogel/AgNW materials were fabricated on a flexible polyethylene terephthalate (PET) film. Through the combination of these composite materials and the ridge micropatterns, the outgrowth of neurites could be efficiently guided in a controlled manner. Therefore, this conductive PEG hydrogel/AgNW micropattern-based sensor could potentially allow future use of the flexible device as an implant for NSC therapy applications.

AB - One of the main challenges regarding treatment of neurodegenerative diseases in the central nervous system (CNS) lies in the inability of neurons to undergo mitosis. Stem cell therapy could provide a possible solution to treat the neurodegenerative diseases. Here, we developed a conductive polyethylene glycol (PEG) hydrogel/silver nanowire (AgNW) composite micropattern-based sensor to direct differentiation of neuronal stem cells (NSCs) and guidance of neurite outgrowth. The ridge micropatterns made from the composite PEG hydrogel/AgNW materials were fabricated on a flexible polyethylene terephthalate (PET) film. Through the combination of these composite materials and the ridge micropatterns, the outgrowth of neurites could be efficiently guided in a controlled manner. Therefore, this conductive PEG hydrogel/AgNW micropattern-based sensor could potentially allow future use of the flexible device as an implant for NSC therapy applications.

KW - Electrical stimuli

KW - Micropattern

KW - Nanowire

KW - Neural stem cell differentiation

KW - Sensor

UR - https://www.scopus.com/pages/publications/85037375327

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DO - 10.1016/j.snb.2017.11.151

M3 - Article

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SN - 0925-4005

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JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

ER -

Conductive hydrogel/nanowire micropattern-based sensor for neural stem cell differentiation

Abstract

Keywords

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