Comprehensive molecular profiling of single circulating tumor cells from lung cancer patients

Seung Min Park; Dawson J. Wong; Chin Chun Ooi; David M. Kurtz; Ophir Vermesh; Amin Aalipour; Susie Suh; Kelsey L. Pian; Jacob J. Chabon; Sang Hun Lee; Mehran Jamali; Carmen Say; Justin N. Carter; Luke P. Lee; Ware G. Kuschner; Erich J. Schwartz; Joseph B. Shrager; Joel W. Neal; Heather A. Wakelee; Maximilian Diehn; Viswam S. Nair; Shan X. Wang; Sanjiv S. Gambhir

Comprehensive molecular profiling of single circulating tumor cells from lung cancer patients

Seung Min Park
, Dawson J. Wong
, Chin Chun Ooi
, David M. Kurtz
, Ophir Vermesh
, Amin Aalipour
, Susie Suh
, Kelsey L. Pian
, Jacob J. Chabon
, Sang Hun Lee
, Mehran Jamali
, Carmen Say
, Justin N. Carter
, Luke P. Lee
, Ware G. Kuschner
, Erich J. Schwartz
, Joseph B. Shrager
, Joel W. Neal
, Heather A. Wakelee
, Maximilian Diehn

Viswam S. Nair, Shan X. Wang, Sanjiv S. Gambhir

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

There exists an urgent need for minimally invasive molecular analysis tools for cancer assessment and management, particularly in advanced-stage lung cancer, when tissue procurement is challenging and gene mutation profiling is crucial to identify molecularly targeted agents for treatment. High-throughput compartmentalization and multigene profiling of individual CTCs from whole blood samples using modular gene panels may facilitate highly sensitive, yet minimally-invasive characterization of lung cancer for therapy prediction and monitoring. We envision this nano-platform as a compelling research tool to investigate the dynamics of cancer disease processes, as well as a viable clinical platform for minimally-invasive yet comprehensive cancer assessment.

Original language	English
Title of host publication	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Publisher	Chemical and Biological Microsystems Society
Pages	73-74
Number of pages	2
ISBN (Electronic)	9780979806490
State	Published - 2016
Externally published	Yes
Event	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland Duration: 9 Oct 2016 → 13 Oct 2016

Publication series

Name	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

Conference

Conference	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Country/Territory	Ireland
City	Dublin
Period	9/10/16 → 13/10/16

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Circulating tumor cell
Gene expression
Magnetic separation
Microfluidic

Cite this

Park, S. M., Wong, D. J., Ooi, C. C., Kurtz, D. M., Vermesh, O., Aalipour, A., Suh, S., Pian, K. L., Chabon, J. J., Lee, S. H., Jamali, M., Say, C., Carter, J. N., Lee, L. P., Kuschner, W. G., Schwartz, E. J., Shrager, J. B., Neal, J. W., Wakelee, H. A., ... Gambhir, S. S. (2016). Comprehensive molecular profiling of single circulating tumor cells from lung cancer patients. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 (pp. 73-74). (20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016). Chemical and Biological Microsystems Society.

Park, Seung Min ; Wong, Dawson J. ; Ooi, Chin Chun et al. / Comprehensive molecular profiling of single circulating tumor cells from lung cancer patients. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, 2016. pp. 73-74 (20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016).

@inproceedings{295842ea3b744b6096127d2d6c5032a5,

title = "Comprehensive molecular profiling of single circulating tumor cells from lung cancer patients",

abstract = "There exists an urgent need for minimally invasive molecular analysis tools for cancer assessment and management, particularly in advanced-stage lung cancer, when tissue procurement is challenging and gene mutation profiling is crucial to identify molecularly targeted agents for treatment. High-throughput compartmentalization and multigene profiling of individual CTCs from whole blood samples using modular gene panels may facilitate highly sensitive, yet minimally-invasive characterization of lung cancer for therapy prediction and monitoring. We envision this nano-platform as a compelling research tool to investigate the dynamics of cancer disease processes, as well as a viable clinical platform for minimally-invasive yet comprehensive cancer assessment.",

keywords = "Circulating tumor cell, Gene expression, Magnetic separation, Microfluidic",

author = "Park, \{Seung Min\} and Wong, \{Dawson J.\} and Ooi, \{Chin Chun\} and Kurtz, \{David M.\} and Ophir Vermesh and Amin Aalipour and Susie Suh and Pian, \{Kelsey L.\} and Chabon, \{Jacob J.\} and Lee, \{Sang Hun\} and Mehran Jamali and Carmen Say and Carter, \{Justin N.\} and Lee, \{Luke P.\} and Kuschner, \{Ware G.\} and Schwartz, \{Erich J.\} and Shrager, \{Joseph B.\} and Neal, \{Joel W.\} and Wakelee, \{Heather A.\} and Maximilian Diehn and Nair, \{Viswam S.\} and Wang, \{Shan X.\} and Gambhir, \{Sanjiv S.\}",

year = "2016",

language = "English",

series = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",

publisher = "Chemical and Biological Microsystems Society",

pages = "73--74",

booktitle = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",

note = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 ; Conference date: 09-10-2016 Through 13-10-2016",

}

Park, SM, Wong, DJ, Ooi, CC, Kurtz, DM, Vermesh, O, Aalipour, A, Suh, S, Pian, KL, Chabon, JJ, Lee, SH, Jamali, M, Say, C, Carter, JN, Lee, LP, Kuschner, WG, Schwartz, EJ, Shrager, JB, Neal, JW, Wakelee, HA, Diehn, M, Nair, VS, Wang, SX & Gambhir, SS 2016, Comprehensive molecular profiling of single circulating tumor cells from lung cancer patients. in 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, Chemical and Biological Microsystems Society, pp. 73-74, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, Dublin, Ireland, 9/10/16.

Comprehensive molecular profiling of single circulating tumor cells from lung cancer patients. / Park, Seung Min; Wong, Dawson J.; Ooi, Chin Chun et al.
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, 2016. p. 73-74 (20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Comprehensive molecular profiling of single circulating tumor cells from lung cancer patients

AU - Park, Seung Min

AU - Wong, Dawson J.

AU - Ooi, Chin Chun

AU - Kurtz, David M.

AU - Vermesh, Ophir

AU - Aalipour, Amin

AU - Suh, Susie

AU - Pian, Kelsey L.

AU - Chabon, Jacob J.

AU - Lee, Sang Hun

AU - Jamali, Mehran

AU - Say, Carmen

AU - Carter, Justin N.

AU - Lee, Luke P.

AU - Kuschner, Ware G.

AU - Schwartz, Erich J.

AU - Shrager, Joseph B.

AU - Neal, Joel W.

AU - Wakelee, Heather A.

AU - Diehn, Maximilian

AU - Nair, Viswam S.

AU - Wang, Shan X.

AU - Gambhir, Sanjiv S.

PY - 2016

Y1 - 2016

N2 - There exists an urgent need for minimally invasive molecular analysis tools for cancer assessment and management, particularly in advanced-stage lung cancer, when tissue procurement is challenging and gene mutation profiling is crucial to identify molecularly targeted agents for treatment. High-throughput compartmentalization and multigene profiling of individual CTCs from whole blood samples using modular gene panels may facilitate highly sensitive, yet minimally-invasive characterization of lung cancer for therapy prediction and monitoring. We envision this nano-platform as a compelling research tool to investigate the dynamics of cancer disease processes, as well as a viable clinical platform for minimally-invasive yet comprehensive cancer assessment.

AB - There exists an urgent need for minimally invasive molecular analysis tools for cancer assessment and management, particularly in advanced-stage lung cancer, when tissue procurement is challenging and gene mutation profiling is crucial to identify molecularly targeted agents for treatment. High-throughput compartmentalization and multigene profiling of individual CTCs from whole blood samples using modular gene panels may facilitate highly sensitive, yet minimally-invasive characterization of lung cancer for therapy prediction and monitoring. We envision this nano-platform as a compelling research tool to investigate the dynamics of cancer disease processes, as well as a viable clinical platform for minimally-invasive yet comprehensive cancer assessment.

KW - Circulating tumor cell

KW - Gene expression

KW - Magnetic separation

KW - Microfluidic

UR - https://www.scopus.com/pages/publications/85014138855

M3 - Conference contribution

AN - SCOPUS:85014138855

T3 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

SP - 73

EP - 74

BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

PB - Chemical and Biological Microsystems Society

T2 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

Y2 - 9 October 2016 through 13 October 2016

ER -

Park SM, Wong DJ, Ooi CC, Kurtz DM, Vermesh O, Aalipour A et al. Comprehensive molecular profiling of single circulating tumor cells from lung cancer patients. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society. 2016. p. 73-74. (20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016).

Comprehensive molecular profiling of single circulating tumor cells from lung cancer patients

Abstract

Publication series

Conference

UN SDGs

Keywords

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Cite this