Comparative Molecular Life History of Spontaneous Canine and Human Gliomas

Samirkumar B. Amin; Kevin J. Anderson; C. Elizabeth Boudreau; Emmanuel Martinez-Ledesma; Emre Kocakavuk; Kevin C. Johnson; Floris P. Barthel; Frederick S. Varn; Cynthia Kassab; Xiaoyang Ling; Hoon Kim; Mary Barter; Ching C. Lau; Chew Yee Ngan; Margaret Chapman; Jennifer W. Koehler; James P. Long; Andrew D. Miller; C. Ryan Miller; Brian F. Porter; Daniel R. Rissi; Christina Mazcko; Amy K. LeBlanc; Peter J. Dickinson; Rebecca A. Packer; Amanda R. Taylor; John H. Rossmeisl; Kevin D. Woolard; Amy B. Heimberger; Jonathan M. Levine; Roel G.W. Verhaak

doi:10.1016/j.ccell.2020.01.004

Comparative Molecular Life History of Spontaneous Canine and Human Gliomas

Samirkumar B. Amin
, Kevin J. Anderson
, C. Elizabeth Boudreau
, Emmanuel Martinez-Ledesma
, Emre Kocakavuk
, Kevin C. Johnson
, Floris P. Barthel
, Frederick S. Varn
, Cynthia Kassab
, Xiaoyang Ling
, Hoon Kim
, Mary Barter
, Ching C. Lau
, Chew Yee Ngan
, Margaret Chapman
, Jennifer W. Koehler
, James P. Long
, Andrew D. Miller
, C. Ryan Miller
, Brian F. Porter

Daniel R. Rissi, Christina Mazcko, Amy K. LeBlanc, Peter J. Dickinson, Rebecca A. Packer, Amanda R. Taylor, John H. Rossmeisl, Kevin D. Woolard, Amy B. Heimberger, Jonathan M. Levine, Roel G.W. Verhaak

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Amin et al. characterize the molecular landscape of canine gliomas and compare it with that of human pediatric and adult gliomas, revealing high similarity between human pediatric and canine gliomas. The cross-species analysis identifies conserved glioma drivers and aneuploidy as a hallmark of high-grade disease.

Original language	English
Pages (from-to)	243-257.e7
Journal	Cancer Cell
Volume	37
Issue number	2
DOIs	https://doi.org/10.1016/j.ccell.2020.01.004
State	Published - 10 Feb 2020
Externally published	Yes

Keywords

adult glioma
canine glioma
comparative genomics
comparative oncology
computational biology
life history
mutagenesis
pediatric glioma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccell.2020.01.004

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Amin, S. B., Anderson, K. J., Boudreau, C. E., Martinez-Ledesma, E., Kocakavuk, E., Johnson, K. C., Barthel, F. P., Varn, F. S., Kassab, C., Ling, X., Kim, H., Barter, M., Lau, C. C., Ngan, C. Y., Chapman, M., Koehler, J. W., Long, J. P., Miller, A. D., Miller, C. R., ... Verhaak, R. G. W. (2020). Comparative Molecular Life History of Spontaneous Canine and Human Gliomas. Cancer Cell, 37(2), 243-257.e7. https://doi.org/10.1016/j.ccell.2020.01.004

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title = "Comparative Molecular Life History of Spontaneous Canine and Human Gliomas",

abstract = "Amin et al. characterize the molecular landscape of canine gliomas and compare it with that of human pediatric and adult gliomas, revealing high similarity between human pediatric and canine gliomas. The cross-species analysis identifies conserved glioma drivers and aneuploidy as a hallmark of high-grade disease.",

keywords = "adult glioma, canine glioma, comparative genomics, comparative oncology, computational biology, life history, mutagenesis, pediatric glioma",

author = "Amin, \{Samirkumar B.\} and Anderson, \{Kevin J.\} and Boudreau, \{C. Elizabeth\} and Emmanuel Martinez-Ledesma and Emre Kocakavuk and Johnson, \{Kevin C.\} and Barthel, \{Floris P.\} and Varn, \{Frederick S.\} and Cynthia Kassab and Xiaoyang Ling and Hoon Kim and Mary Barter and Lau, \{Ching C.\} and Ngan, \{Chew Yee\} and Margaret Chapman and Koehler, \{Jennifer W.\} and Long, \{James P.\} and Miller, \{Andrew D.\} and Miller, \{C. Ryan\} and Porter, \{Brian F.\} and Rissi, \{Daniel R.\} and Christina Mazcko and LeBlanc, \{Amy K.\} and Dickinson, \{Peter J.\} and Packer, \{Rebecca A.\} and Taylor, \{Amanda R.\} and Rossmeisl, \{John H.\} and Woolard, \{Kevin D.\} and Heimberger, \{Amy B.\} and Levine, \{Jonathan M.\} and Verhaak, \{Roel G.W.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = feb,

day = "10",

doi = "10.1016/j.ccell.2020.01.004",

language = "English",

volume = "37",

pages = "243--257.e7",

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Amin, SB, Anderson, KJ, Boudreau, CE, Martinez-Ledesma, E, Kocakavuk, E, Johnson, KC, Barthel, FP, Varn, FS, Kassab, C, Ling, X, Kim, H, Barter, M, Lau, CC, Ngan, CY, Chapman, M, Koehler, JW, Long, JP, Miller, AD, Miller, CR, Porter, BF, Rissi, DR, Mazcko, C, LeBlanc, AK, Dickinson, PJ, Packer, RA, Taylor, AR, Rossmeisl, JH, Woolard, KD, Heimberger, AB, Levine, JM & Verhaak, RGW 2020, 'Comparative Molecular Life History of Spontaneous Canine and Human Gliomas', Cancer Cell, vol. 37, no. 2, pp. 243-257.e7. https://doi.org/10.1016/j.ccell.2020.01.004

TY - JOUR

T1 - Comparative Molecular Life History of Spontaneous Canine and Human Gliomas

AU - Amin, Samirkumar B.

AU - Anderson, Kevin J.

AU - Boudreau, C. Elizabeth

AU - Martinez-Ledesma, Emmanuel

AU - Kocakavuk, Emre

AU - Johnson, Kevin C.

AU - Barthel, Floris P.

AU - Varn, Frederick S.

AU - Kassab, Cynthia

AU - Ling, Xiaoyang

AU - Kim, Hoon

AU - Barter, Mary

AU - Lau, Ching C.

AU - Ngan, Chew Yee

AU - Chapman, Margaret

AU - Koehler, Jennifer W.

AU - Long, James P.

AU - Miller, Andrew D.

AU - Miller, C. Ryan

AU - Porter, Brian F.

AU - Rissi, Daniel R.

AU - Mazcko, Christina

AU - LeBlanc, Amy K.

AU - Dickinson, Peter J.

AU - Packer, Rebecca A.

AU - Taylor, Amanda R.

AU - Rossmeisl, John H.

AU - Woolard, Kevin D.

AU - Heimberger, Amy B.

AU - Levine, Jonathan M.

AU - Verhaak, Roel G.W.

PY - 2020/2/10

Y1 - 2020/2/10

N2 - Amin et al. characterize the molecular landscape of canine gliomas and compare it with that of human pediatric and adult gliomas, revealing high similarity between human pediatric and canine gliomas. The cross-species analysis identifies conserved glioma drivers and aneuploidy as a hallmark of high-grade disease.

AB - Amin et al. characterize the molecular landscape of canine gliomas and compare it with that of human pediatric and adult gliomas, revealing high similarity between human pediatric and canine gliomas. The cross-species analysis identifies conserved glioma drivers and aneuploidy as a hallmark of high-grade disease.

KW - adult glioma

KW - canine glioma

KW - comparative genomics

KW - comparative oncology

KW - computational biology

KW - life history

KW - mutagenesis

KW - pediatric glioma

UR - https://www.scopus.com/pages/publications/85078852466

U2 - 10.1016/j.ccell.2020.01.004

DO - 10.1016/j.ccell.2020.01.004

M3 - Article

C2 - 32049048

AN - SCOPUS:85078852466

SN - 1535-6108

VL - 37

SP - 243-257.e7

JO - Cancer Cell

JF - Cancer Cell

IS - 2

ER -

Comparative Molecular Life History of Spontaneous Canine and Human Gliomas

Abstract

Keywords

UN SDGs

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