TY - JOUR
T1 - Clinical significance of microvessel density in multiple myeloma patients
AU - Ahn, Myung Ju
AU - Park, Chan Kum
AU - Choi, Jung Hye
AU - Lee, Won Mee
AU - Lee, Young Yeul
AU - Choi, Il Young
AU - Kim, In Soon
AU - Lee, Woong Soo
AU - Ki, Moran
PY - 2001/2
Y1 - 2001/2
N2 - To investigate the role of angiogenesis in multiple myeloma (MM), bone marrow biopsy from 75 adults with newly diagnosed, untreated MM were evaluated. Microvessels were scored in at least 3 areas (x200 fields) of the highest microvessel density in representative sections of each bone marrow specimen using immunohistochemistry for CD34. Prognostic variables were also evaluated for the overall survival. Microvessel counts were significantly higher in patients with MM (n=69.42±9.67), compared with control (n=26.81±2.85). Microvessel density had a weak correlation with percentage of bone marrow plasma cells. By univariate analysis, age, β2-microglobulin, serum albumin, serum creatinine, serum calcium, hemoglobin, platelet count, and bone marrow plasma cell percentage were correlated with survival. By multivariate analysis, age, serum albumin, serum creatinine, hemoglobin, platelet count and bone marrow plasma cell percentage were correlated with overall survival, whereas microvessel density was not. In summary, microvessel density in bone marrow of MM is significantly increased compared to control, but was not correlated with overall survival. Further studies regarding angiogeneic molecules are needed to determine the functional role of angiogenesis in MM.
AB - To investigate the role of angiogenesis in multiple myeloma (MM), bone marrow biopsy from 75 adults with newly diagnosed, untreated MM were evaluated. Microvessels were scored in at least 3 areas (x200 fields) of the highest microvessel density in representative sections of each bone marrow specimen using immunohistochemistry for CD34. Prognostic variables were also evaluated for the overall survival. Microvessel counts were significantly higher in patients with MM (n=69.42±9.67), compared with control (n=26.81±2.85). Microvessel density had a weak correlation with percentage of bone marrow plasma cells. By univariate analysis, age, β2-microglobulin, serum albumin, serum creatinine, serum calcium, hemoglobin, platelet count, and bone marrow plasma cell percentage were correlated with survival. By multivariate analysis, age, serum albumin, serum creatinine, hemoglobin, platelet count and bone marrow plasma cell percentage were correlated with overall survival, whereas microvessel density was not. In summary, microvessel density in bone marrow of MM is significantly increased compared to control, but was not correlated with overall survival. Further studies regarding angiogeneic molecules are needed to determine the functional role of angiogenesis in MM.
KW - Microvessel Density
KW - Multiple Myeloma
KW - Survival
UR - https://www.scopus.com/pages/publications/0035259958
U2 - 10.3346/jkms.2001.16.1.45
DO - 10.3346/jkms.2001.16.1.45
M3 - Article
C2 - 11289400
AN - SCOPUS:0035259958
SN - 1011-8934
VL - 16
SP - 45
EP - 50
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
IS - 1
ER -