TY - JOUR
T1 - Chronic obstructive pulmonary disease
T2 - Lobe-based visual assessment of volumetric CT by using standard images - Comparison with quantitative CT and pulmonary function test in the COPDGene study
AU - Kim, Song Soo
AU - Seo, Joon Beom
AU - Lee, Ho Yun
AU - Nevrekar, Dipti V.
AU - Forssen, Anna V.
AU - Crapo, James D.
AU - Schroeder, Joyce D.
AU - Lynch, David A.
PY - 2013/2
Y1 - 2013/2
N2 - Purposes: To provide a new detailed visual assessment scheme of computed tomography (CT) for chronic obstructive pulmonary disease (COPD) by using standard reference images and to compare this visual assessment method with quantitative CT and several physiologic parameters. Materials and This research was approved by the institutional review Methods: board of each institution. CT images of 200 participants in the COPDGene study were evaluated. Four thoracic radiologists performed independent, lobar analysis of volumetric CT images for type (centrilobular, panlobular, and mixed) and extent (on a six-point scale) of emphysema, the presence of bronchiectasis, airway wall thickening, and tracheal abnormalities. Standard images for each fnding, generated by two radiologists, were used for reference. The extent of emphysema, airway wall thickening, and luminal area were quantified at the lobar level by using commercial software. Spearman rank test and simple and multiple regression analyses were performed to compare the results of visual assessment with physiologic and quantitative parameters. Results: The type of emphysema, determined by four readers, showed good agreement (κ = 0.63). The extent of the emphysema in each lobe showed good agreement (mean weighted κ = 0.70) and correlated with fndings at quantitative CT (r = 0.75), forced expiratory volume in 1 second (FEV 1) (r = 20.68), FEV1/forced vital capacity (FVC) ratio (r = 20.74) (P <.001). Agreement for airway wall thickening was fair (mean κ = 0.41), and the number of lobes with thickened bronchial walls correlated with FEV1 (r = 20.60) and FEV1/FVC ratio (r = -20.60) (P <.001). Conclusion: Visual assessment of emphysema and airways disease in individuals with COPD can provide reproducible, physiologically substantial information that may complement that provided by quantitative CT assessment.
AB - Purposes: To provide a new detailed visual assessment scheme of computed tomography (CT) for chronic obstructive pulmonary disease (COPD) by using standard reference images and to compare this visual assessment method with quantitative CT and several physiologic parameters. Materials and This research was approved by the institutional review Methods: board of each institution. CT images of 200 participants in the COPDGene study were evaluated. Four thoracic radiologists performed independent, lobar analysis of volumetric CT images for type (centrilobular, panlobular, and mixed) and extent (on a six-point scale) of emphysema, the presence of bronchiectasis, airway wall thickening, and tracheal abnormalities. Standard images for each fnding, generated by two radiologists, were used for reference. The extent of emphysema, airway wall thickening, and luminal area were quantified at the lobar level by using commercial software. Spearman rank test and simple and multiple regression analyses were performed to compare the results of visual assessment with physiologic and quantitative parameters. Results: The type of emphysema, determined by four readers, showed good agreement (κ = 0.63). The extent of the emphysema in each lobe showed good agreement (mean weighted κ = 0.70) and correlated with fndings at quantitative CT (r = 0.75), forced expiratory volume in 1 second (FEV 1) (r = 20.68), FEV1/forced vital capacity (FVC) ratio (r = 20.74) (P <.001). Agreement for airway wall thickening was fair (mean κ = 0.41), and the number of lobes with thickened bronchial walls correlated with FEV1 (r = 20.60) and FEV1/FVC ratio (r = -20.60) (P <.001). Conclusion: Visual assessment of emphysema and airways disease in individuals with COPD can provide reproducible, physiologically substantial information that may complement that provided by quantitative CT assessment.
UR - https://www.scopus.com/pages/publications/84873342279
U2 - 10.1148/radiol.12120385
DO - 10.1148/radiol.12120385
M3 - Article
C2 - 23220894
AN - SCOPUS:84873342279
SN - 0033-8419
VL - 266
SP - 626
EP - 635
JO - Radiology
JF - Radiology
IS - 2
ER -