TY - JOUR
T1 - Chronic cerebral hypoperfusion
T2 - a critical feature in unravelling the etiology of vascular cognitive impairment
AU - Rajeev, Vismitha
AU - Chai, Yuek Ling
AU - Poh, Luting
AU - Selvaraji, Sharmelee
AU - Fann, David Y.
AU - Jo, Dong Gyu
AU - De Silva, T. Michael
AU - Drummond, Grant R.
AU - Sobey, Christopher G.
AU - Arumugam, Thiruma V.
AU - Chen, Christopher P.
AU - Lai, Mitchell K.P.
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - Vascular cognitive impairment (VCI) describes a wide spectrum of cognitive deficits related to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically involved in cognitive processes must feature as the main driver of VCI, the underlying mechanisms and interactions with related disease processes remain to be fully elucidated. Recent clinical studies of cerebral blood flow measurements have supported the role of chronic cerebral hypoperfusion (CCH) as a major driver of the vascular pathology and clinical manifestations of VCI. Here we review the pathophysiological mechanisms as well as neuropathological changes of CCH. Potential interventional strategies for VCI are also reviewed. A deeper understanding of how CCH can lead to accumulation of VCI-associated pathology could potentially pave the way for early detection and development of disease-modifying therapies, thus allowing preventive interventions instead of symptomatic treatments.
AB - Vascular cognitive impairment (VCI) describes a wide spectrum of cognitive deficits related to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically involved in cognitive processes must feature as the main driver of VCI, the underlying mechanisms and interactions with related disease processes remain to be fully elucidated. Recent clinical studies of cerebral blood flow measurements have supported the role of chronic cerebral hypoperfusion (CCH) as a major driver of the vascular pathology and clinical manifestations of VCI. Here we review the pathophysiological mechanisms as well as neuropathological changes of CCH. Potential interventional strategies for VCI are also reviewed. A deeper understanding of how CCH can lead to accumulation of VCI-associated pathology could potentially pave the way for early detection and development of disease-modifying therapies, thus allowing preventive interventions instead of symptomatic treatments.
KW - Chronic cerebral hypoperfusion
KW - Neuronal cell death
KW - Vascular dementia
KW - White matter lesions
UR - https://www.scopus.com/pages/publications/85161947166
U2 - 10.1186/s40478-023-01590-1
DO - 10.1186/s40478-023-01590-1
M3 - Review article
C2 - 37309012
AN - SCOPUS:85161947166
SN - 2051-5960
VL - 11
JO - Acta Neuropathologica Communications
JF - Acta Neuropathologica Communications
IS - 1
M1 - 93
ER -
