Chemical constituents from the roots of Cynanchum paniculatum and their cytotoxic activity

Chung Sub Kim; Ju Yeoun Oh; Sang Un Choi; Kang Ro Lee

doi:10.1016/j.carres.2013.08.023

Chemical constituents from the roots of Cynanchum paniculatum and their cytotoxic activity

Chung Sub Kim
, Ju Yeoun Oh
, Sang Un Choi
, Kang Ro Lee

Department of Pharmacy

Sungkyunkwan University
Korea Research Institute of Chemical Technology

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Two new steroidal saponins, cynanside A (1) and B (2) were isolated together with three known compounds (3-5) from the roots of Cynanchum paniculatum (Bunge) Kitag. The structures of 1 and 2 were elucidated on the basis of spectroscopic analyses, including extensive 2D NMR and acid hydrolysis. We evaluated the cytotoxicity of isolates (1-5) against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines in vitro using the SRB bioassay. Compounds 1 and 2 showed selective cytotoxicity against SK-MEL-2 cells with IC₅₀ values of 26.55 and 17.36 μM, respectively.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Carbohydrate Research
Volume	381
DOIs	https://doi.org/10.1016/j.carres.2013.08.023
State	Published - 2013

Keywords

Asclepiadaceae
Cynanchum paniculatum
Cytotoxicity
Steroidal glycosides

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10.1016/j.carres.2013.08.023

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title = "Chemical constituents from the roots of Cynanchum paniculatum and their cytotoxic activity",

abstract = "Two new steroidal saponins, cynanside A (1) and B (2) were isolated together with three known compounds (3-5) from the roots of Cynanchum paniculatum (Bunge) Kitag. The structures of 1 and 2 were elucidated on the basis of spectroscopic analyses, including extensive 2D NMR and acid hydrolysis. We evaluated the cytotoxicity of isolates (1-5) against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines in vitro using the SRB bioassay. Compounds 1 and 2 showed selective cytotoxicity against SK-MEL-2 cells with IC50 values of 26.55 and 17.36 μM, respectively.",

keywords = "Asclepiadaceae, Cynanchum paniculatum, Cytotoxicity, Steroidal glycosides",

author = "Kim, \{Chung Sub\} and Oh, \{Ju Yeoun\} and Choi, \{Sang Un\} and Lee, \{Kang Ro\}",

year = "2013",

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language = "English",

volume = "381",

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journal = "Carbohydrate Research",

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T1 - Chemical constituents from the roots of Cynanchum paniculatum and their cytotoxic activity

AU - Kim, Chung Sub

AU - Oh, Ju Yeoun

AU - Choi, Sang Un

AU - Lee, Kang Ro

PY - 2013

Y1 - 2013

N2 - Two new steroidal saponins, cynanside A (1) and B (2) were isolated together with three known compounds (3-5) from the roots of Cynanchum paniculatum (Bunge) Kitag. The structures of 1 and 2 were elucidated on the basis of spectroscopic analyses, including extensive 2D NMR and acid hydrolysis. We evaluated the cytotoxicity of isolates (1-5) against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines in vitro using the SRB bioassay. Compounds 1 and 2 showed selective cytotoxicity against SK-MEL-2 cells with IC50 values of 26.55 and 17.36 μM, respectively.

AB - Two new steroidal saponins, cynanside A (1) and B (2) were isolated together with three known compounds (3-5) from the roots of Cynanchum paniculatum (Bunge) Kitag. The structures of 1 and 2 were elucidated on the basis of spectroscopic analyses, including extensive 2D NMR and acid hydrolysis. We evaluated the cytotoxicity of isolates (1-5) against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines in vitro using the SRB bioassay. Compounds 1 and 2 showed selective cytotoxicity against SK-MEL-2 cells with IC50 values of 26.55 and 17.36 μM, respectively.

KW - Asclepiadaceae

KW - Cynanchum paniculatum

KW - Cytotoxicity

KW - Steroidal glycosides

UR - https://www.scopus.com/pages/publications/84883871782

U2 - 10.1016/j.carres.2013.08.023

DO - 10.1016/j.carres.2013.08.023

M3 - Article

C2 - 24051209

AN - SCOPUS:84883871782

SN - 0008-6215

VL - 381

SP - 1

EP - 5

JO - Carbohydrate Research

JF - Carbohydrate Research

ER -

Chemical constituents from the roots of Cynanchum paniculatum and their cytotoxic activity

Abstract

Keywords

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