Cellular Stress Upregulates Indole Signaling Metabolites in Escherichia coli

Chung Sub Kim; Jhe Hao Li; Brenden Barco; Hyun Bong Park; Alexandra Gatsios; Ashiti Damania; Rurun Wang; Thomas P. Wyche; Grazia Piizzi; Nicole K. Clay; Jason M. Crawford

doi:10.1016/j.chembiol.2020.03.003

Cellular Stress Upregulates Indole Signaling Metabolites in Escherichia coli

Chung Sub Kim, Jhe Hao Li, Brenden Barco, Hyun Bong Park, Alexandra Gatsios, Ashiti Damania, Rurun Wang, Thomas P. Wyche, Grazia Piizzi, Nicole K. Clay, Jason M. Crawford

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Kim, Li, et al. describe the characterization of cellular stress-induced, bacterial indole-functionalized metabolites termed “indolokines.” The indolokines are found in diverse bacteria, enhance persister formation in E. coli, and activate innate immune responses in both plant and human tissues.

Original language	English
Pages (from-to)	698-707.e7
Journal	Cell Chemical Biology
Volume	27
Issue number	6
DOIs	https://doi.org/10.1016/j.chembiol.2020.03.003
State	Published - 18 Jun 2020

Keywords

antibiotic tolerance
E. coli
host-bacteria interactions
IL-6
indole
innate immunity
persister cell
signaling
stress response

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10.1016/j.chembiol.2020.03.003

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@article{c2ef31ee0ee044a0aa88288dd41024c8,

title = "Cellular Stress Upregulates Indole Signaling Metabolites in Escherichia coli",

abstract = "Kim, Li, et al. describe the characterization of cellular stress-induced, bacterial indole-functionalized metabolites termed “indolokines.” The indolokines are found in diverse bacteria, enhance persister formation in E. coli, and activate innate immune responses in both plant and human tissues.",

keywords = "antibiotic tolerance, E. coli, host-bacteria interactions, IL-6, indole, innate immunity, persister cell, signaling, stress response",

author = "Kim, \{Chung Sub\} and Li, \{Jhe Hao\} and Brenden Barco and Park, \{Hyun Bong\} and Alexandra Gatsios and Ashiti Damania and Rurun Wang and Wyche, \{Thomas P.\} and Grazia Piizzi and Clay, \{Nicole K.\} and Crawford, \{Jason M.\}",

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year = "2020",

month = jun,

day = "18",

doi = "10.1016/j.chembiol.2020.03.003",

language = "English",

volume = "27",

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T1 - Cellular Stress Upregulates Indole Signaling Metabolites in Escherichia coli

AU - Kim, Chung Sub

AU - Li, Jhe Hao

AU - Barco, Brenden

AU - Park, Hyun Bong

AU - Gatsios, Alexandra

AU - Damania, Ashiti

AU - Wang, Rurun

AU - Wyche, Thomas P.

AU - Piizzi, Grazia

AU - Clay, Nicole K.

AU - Crawford, Jason M.

PY - 2020/6/18

Y1 - 2020/6/18

N2 - Kim, Li, et al. describe the characterization of cellular stress-induced, bacterial indole-functionalized metabolites termed “indolokines.” The indolokines are found in diverse bacteria, enhance persister formation in E. coli, and activate innate immune responses in both plant and human tissues.

AB - Kim, Li, et al. describe the characterization of cellular stress-induced, bacterial indole-functionalized metabolites termed “indolokines.” The indolokines are found in diverse bacteria, enhance persister formation in E. coli, and activate innate immune responses in both plant and human tissues.

KW - antibiotic tolerance

KW - E. coli

KW - host-bacteria interactions

KW - IL-6

KW - indole

KW - innate immunity

KW - persister cell

KW - signaling

KW - stress response

UR - https://www.scopus.com/pages/publications/85083335630

U2 - 10.1016/j.chembiol.2020.03.003

DO - 10.1016/j.chembiol.2020.03.003

M3 - Article

C2 - 32243812

AN - SCOPUS:85083335630

SN - 2451-9456

VL - 27

SP - 698-707.e7

JO - Cell Chemical Biology

JF - Cell Chemical Biology

IS - 6

ER -

Cellular Stress Upregulates Indole Signaling Metabolites in Escherichia coli

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Keywords

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