CdSe@ZnS/ZnS quantum dots loaded in polymeric micelles as a pH-triggerable targeting fluorescence imaging probe for detecting cerebral ischemic area

Hong Yu Yang; Yan Fu; Moon Sun Jang; Yi Li; Wen Ping Yin; Tae Kyu Ahn; Jung Hee Lee; Heeyeop Chae; Doo Sung Lee

doi:10.1016/j.colsurfb.2017.04.054

CdSe@ZnS/ZnS quantum dots loaded in polymeric micelles as a pH-triggerable targeting fluorescence imaging probe for detecting cerebral ischemic area

Hong Yu Yang, Yan Fu, Moon Sun Jang, Yi Li, Wen Ping Yin, Tae Kyu Ahn, Jung Hee Lee, Heeyeop Chae, Doo Sung Lee

Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

High photoluminescence (PL) quantum yield (QY), photostability CdSe@ZnS/ZnS core/multishell quantum dots (CM-QDs) were first applied for bioimaging. The solubility, stability and biocompatible of the fluorescence imaging probes were constructed by self-assembly of CM-QDs and pH-responsive methoxy poly(ethylene glycol)-poly(β-amino ester/amidoamine)-dodecylamine (mPEG-PAEA-DDA) multiblock copolymers. The resulting CM-QDs-loaded mPEG-PAEA-DDA micelles (CM-QDs-PEG-PAEA-DDA) exhibited lower cell cytotoxicity and higher fluorescence intensity than the core/shell CdSe@ZnS QDs-encapsulated mPEG-PAEA-DDA micelles (CS-QDs-PEG-PAEA-DDA). Moreover, the in vivo fluorescence imaging ability confirmed that the CM-QDs-PEG-PAEA-DDA can be employed as a pH-triggerable targeting imaging probe for detection of a rat bearing cerebral ischemia disease. Therefore, we believed that the CM-QDs-PEG-PAEA-DDA may be the next generation of fluorescence imaging probes for targeted diagnosis acidic pathological areas, using pH as a stimulus.

Original language	English
Pages (from-to)	497-506
Number of pages	10
Journal	Colloids and Surfaces B: Biointerfaces
Volume	155
DOIs	https://doi.org/10.1016/j.colsurfb.2017.04.054
State	Published - 1 Jul 2017

Keywords

Cerebral ischemic areas
Core/multishell quantum dots
Fluorescence imaging probe
pH-responsive
pH-triggerable targeting
Polymeric micelle

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10.1016/j.colsurfb.2017.04.054

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@article{dc0a65d2f5694c16972ef85c6ff9d7ab,

title = "CdSe@ZnS/ZnS quantum dots loaded in polymeric micelles as a pH-triggerable targeting fluorescence imaging probe for detecting cerebral ischemic area",

abstract = "High photoluminescence (PL) quantum yield (QY), photostability CdSe@ZnS/ZnS core/multishell quantum dots (CM-QDs) were first applied for bioimaging. The solubility, stability and biocompatible of the fluorescence imaging probes were constructed by self-assembly of CM-QDs and pH-responsive methoxy poly(ethylene glycol)-poly(β-amino ester/amidoamine)-dodecylamine (mPEG-PAEA-DDA) multiblock copolymers. The resulting CM-QDs-loaded mPEG-PAEA-DDA micelles (CM-QDs-PEG-PAEA-DDA) exhibited lower cell cytotoxicity and higher fluorescence intensity than the core/shell CdSe@ZnS QDs-encapsulated mPEG-PAEA-DDA micelles (CS-QDs-PEG-PAEA-DDA). Moreover, the in vivo fluorescence imaging ability confirmed that the CM-QDs-PEG-PAEA-DDA can be employed as a pH-triggerable targeting imaging probe for detection of a rat bearing cerebral ischemia disease. Therefore, we believed that the CM-QDs-PEG-PAEA-DDA may be the next generation of fluorescence imaging probes for targeted diagnosis acidic pathological areas, using pH as a stimulus.",

keywords = "Cerebral ischemic areas, Core/multishell quantum dots, Fluorescence imaging probe, pH-responsive, pH-triggerable targeting, Polymeric micelle",

author = "Yang, \{Hong Yu\} and Yan Fu and Jang, \{Moon Sun\} and Yi Li and Yin, \{Wen Ping\} and Ahn, \{Tae Kyu\} and Lee, \{Jung Hee\} and Heeyeop Chae and Lee, \{Doo Sung\}",

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year = "2017",

month = jul,

day = "1",

doi = "10.1016/j.colsurfb.2017.04.054",

language = "English",

volume = "155",

pages = "497--506",

journal = "Colloids and Surfaces B: Biointerfaces",

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TY - JOUR

T1 - CdSe@ZnS/ZnS quantum dots loaded in polymeric micelles as a pH-triggerable targeting fluorescence imaging probe for detecting cerebral ischemic area

AU - Yang, Hong Yu

AU - Fu, Yan

AU - Jang, Moon Sun

AU - Li, Yi

AU - Yin, Wen Ping

AU - Ahn, Tae Kyu

AU - Lee, Jung Hee

AU - Chae, Heeyeop

AU - Lee, Doo Sung

PY - 2017/7/1

Y1 - 2017/7/1

N2 - High photoluminescence (PL) quantum yield (QY), photostability CdSe@ZnS/ZnS core/multishell quantum dots (CM-QDs) were first applied for bioimaging. The solubility, stability and biocompatible of the fluorescence imaging probes were constructed by self-assembly of CM-QDs and pH-responsive methoxy poly(ethylene glycol)-poly(β-amino ester/amidoamine)-dodecylamine (mPEG-PAEA-DDA) multiblock copolymers. The resulting CM-QDs-loaded mPEG-PAEA-DDA micelles (CM-QDs-PEG-PAEA-DDA) exhibited lower cell cytotoxicity and higher fluorescence intensity than the core/shell CdSe@ZnS QDs-encapsulated mPEG-PAEA-DDA micelles (CS-QDs-PEG-PAEA-DDA). Moreover, the in vivo fluorescence imaging ability confirmed that the CM-QDs-PEG-PAEA-DDA can be employed as a pH-triggerable targeting imaging probe for detection of a rat bearing cerebral ischemia disease. Therefore, we believed that the CM-QDs-PEG-PAEA-DDA may be the next generation of fluorescence imaging probes for targeted diagnosis acidic pathological areas, using pH as a stimulus.

AB - High photoluminescence (PL) quantum yield (QY), photostability CdSe@ZnS/ZnS core/multishell quantum dots (CM-QDs) were first applied for bioimaging. The solubility, stability and biocompatible of the fluorescence imaging probes were constructed by self-assembly of CM-QDs and pH-responsive methoxy poly(ethylene glycol)-poly(β-amino ester/amidoamine)-dodecylamine (mPEG-PAEA-DDA) multiblock copolymers. The resulting CM-QDs-loaded mPEG-PAEA-DDA micelles (CM-QDs-PEG-PAEA-DDA) exhibited lower cell cytotoxicity and higher fluorescence intensity than the core/shell CdSe@ZnS QDs-encapsulated mPEG-PAEA-DDA micelles (CS-QDs-PEG-PAEA-DDA). Moreover, the in vivo fluorescence imaging ability confirmed that the CM-QDs-PEG-PAEA-DDA can be employed as a pH-triggerable targeting imaging probe for detection of a rat bearing cerebral ischemia disease. Therefore, we believed that the CM-QDs-PEG-PAEA-DDA may be the next generation of fluorescence imaging probes for targeted diagnosis acidic pathological areas, using pH as a stimulus.

KW - Cerebral ischemic areas

KW - Core/multishell quantum dots

KW - Fluorescence imaging probe

KW - pH-responsive

KW - pH-triggerable targeting

KW - Polymeric micelle

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SN - 0927-7765

VL - 155

SP - 497

EP - 506

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

ER -

CdSe@ZnS/ZnS quantum dots loaded in polymeric micelles as a pH-triggerable targeting fluorescence imaging probe for detecting cerebral ischemic area

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