Capillary electrophoresis electrochemical detector with noble microchannel structure for miniaturization

Numerous researches have been focused on capillary electrophoresis (CE) and amperometric detection (AD) using a double-T micro-channel configuration. The combination of these two techniques becomes a powerful analytical tool due to enhanced features in terms of sensitivity and selectivity. The developed CE- AD chip is low cost and requires less power consumption. Its high compatibility with micro-fabrication technology has made it popular for analysis of different compounds. However, due to the need to further miniaturize the CE-AD device, a twisted CE micro-channel configuration is fabricated and tested in this study. Furthermore, enhanced analyte separation due to delayed response time can be achieved using a serpentine CE separation micro-channel. Phenolic compounds were used as testing analytes to confirm the results using different types of running buffers. Also, the data gathered from the new micro-channel configuration is compared with the previously gathered results obtained from double-T separation micro- channels.