Cancer Incidence in Living Liver Donors After Donor Hepatectomy

Jongman Kim; Jae Heon Kim; Hyun Jung Kim

doi:10.3346/jkms.2023.38.e277

Cancer Incidence in Living Liver Donors After Donor Hepatectomy

Jongman Kim, Jae Heon Kim, Hyun Jung Kim

Department of Surgery

Research output: Contribution to journal › Article › peer-review

Abstract

Living liver donors (LLDs) are screened for transmissible diseases including cancer. We investigated the actual cancer incidence of LLDs compared with a matched healthy control group from the general Korean population using data from the Korean National Health Insurance Services (NHIS). A total of 12,372 LLDs who donated a liver graft between 2002 and 2018 were registered in the Korean Network for Organ Sharing. They were compared to a matched healthy control group selected from the Korean NHIS. Cancer diagnosis was identified in 175 LLDs (1.4%) and 1,014 controls (0.8%). Compared to the healthy control group, the incidence rate ratio of liver and thyroid cancer in the LLD group were significantly higher at 18.30 and 1.39, respectively. The incidences of 11 other specified cancers were not different between the two groups. The present study suggests that LLD after donor hepatectomy may require medical surveillance, especially for liver cancer.

Original language	English
Article number	e277
Journal	Journal of Korean Medical Science
Volume	38
Issue number	35
DOIs	https://doi.org/10.3346/jkms.2023.38.e277
State	Published - 2023

Keywords

Liver Transplantation
Living Liver Donors
Malignancy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3346/jkms.2023.38.e277

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title = "Cancer Incidence in Living Liver Donors After Donor Hepatectomy",

abstract = "Living liver donors (LLDs) are screened for transmissible diseases including cancer. We investigated the actual cancer incidence of LLDs compared with a matched healthy control group from the general Korean population using data from the Korean National Health Insurance Services (NHIS). A total of 12,372 LLDs who donated a liver graft between 2002 and 2018 were registered in the Korean Network for Organ Sharing. They were compared to a matched healthy control group selected from the Korean NHIS. Cancer diagnosis was identified in 175 LLDs (1.4\%) and 1,014 controls (0.8\%). Compared to the healthy control group, the incidence rate ratio of liver and thyroid cancer in the LLD group were significantly higher at 18.30 and 1.39, respectively. The incidences of 11 other specified cancers were not different between the two groups. The present study suggests that LLD after donor hepatectomy may require medical surveillance, especially for liver cancer.",

keywords = "Liver Transplantation, Living Liver Donors, Malignancy",

author = "Jongman Kim and Kim, \{Jae Heon\} and Kim, \{Hyun Jung\}",

note = "Publisher Copyright: {\textcopyright} 2023 The Korean Academy of Medical Sciences.",

year = "2023",

doi = "10.3346/jkms.2023.38.e277",

language = "English",

volume = "38",

journal = "Journal of Korean Medical Science",

issn = "1011-8934",

publisher = "Korean Academy of Medical Science",

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TY - JOUR

T1 - Cancer Incidence in Living Liver Donors After Donor Hepatectomy

AU - Kim, Jongman

AU - Kim, Jae Heon

AU - Kim, Hyun Jung

PY - 2023

Y1 - 2023

N2 - Living liver donors (LLDs) are screened for transmissible diseases including cancer. We investigated the actual cancer incidence of LLDs compared with a matched healthy control group from the general Korean population using data from the Korean National Health Insurance Services (NHIS). A total of 12,372 LLDs who donated a liver graft between 2002 and 2018 were registered in the Korean Network for Organ Sharing. They were compared to a matched healthy control group selected from the Korean NHIS. Cancer diagnosis was identified in 175 LLDs (1.4%) and 1,014 controls (0.8%). Compared to the healthy control group, the incidence rate ratio of liver and thyroid cancer in the LLD group were significantly higher at 18.30 and 1.39, respectively. The incidences of 11 other specified cancers were not different between the two groups. The present study suggests that LLD after donor hepatectomy may require medical surveillance, especially for liver cancer.

AB - Living liver donors (LLDs) are screened for transmissible diseases including cancer. We investigated the actual cancer incidence of LLDs compared with a matched healthy control group from the general Korean population using data from the Korean National Health Insurance Services (NHIS). A total of 12,372 LLDs who donated a liver graft between 2002 and 2018 were registered in the Korean Network for Organ Sharing. They were compared to a matched healthy control group selected from the Korean NHIS. Cancer diagnosis was identified in 175 LLDs (1.4%) and 1,014 controls (0.8%). Compared to the healthy control group, the incidence rate ratio of liver and thyroid cancer in the LLD group were significantly higher at 18.30 and 1.39, respectively. The incidences of 11 other specified cancers were not different between the two groups. The present study suggests that LLD after donor hepatectomy may require medical surveillance, especially for liver cancer.

KW - Liver Transplantation

KW - Living Liver Donors

KW - Malignancy

UR - https://www.scopus.com/pages/publications/85169847593

U2 - 10.3346/jkms.2023.38.e277

DO - 10.3346/jkms.2023.38.e277

M3 - Article

C2 - 37667582

AN - SCOPUS:85169847593

SN - 1011-8934

VL - 38

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

IS - 35

M1 - e277

ER -

Cancer Incidence in Living Liver Donors After Donor Hepatectomy

Abstract

Keywords

UN SDGs

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