Brighter spotty lesions on spinal MRI help differentiate AQP4 antibody-positive NMOSD from MOGAD

Jae Won Hyun; Hye Lim Lee; Jaehong Park; Jiah Kim; Ju Hong Min; Byoung Joon Kim; Seung Woo Kim; Ha Young Shin; So Young Huh; Woojun Kim; Ji Won Seo; Ki Hoon Kim; Su Hyun Kim; Ho Jin Kim

doi:10.1177/13524585211060326

Brighter spotty lesions on spinal MRI help differentiate AQP4 antibody-positive NMOSD from MOGAD

Jae Won Hyun
, Hye Lim Lee
, Jaehong Park
, Jiah Kim
, Ju Hong Min
, Byoung Joon Kim
, Seung Woo Kim
, Ha Young Shin
, So Young Huh
, Woojun Kim
, Ji Won Seo
, Ki Hoon Kim
, Su Hyun Kim
, Ho Jin Kim

Department of Neurology

National Cancer Center Korea
Korea University
Sungkyunkwan University
Yonsei University
Kosin University
The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

In a large acute myelitis cohort, we aimed to determine whether brighter spotty lesions (BSLs)—using the refined terminology—on spinal magnetic resonance imaging (MRI) help distinguish aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) from myelin oligodendrocyte glycoprotein antibody disease (MOGAD). An experienced neuro-radiologist and two neurologists independently analyzed 133 spinal MRI scans (65 from MOGAD and 68 from AQP4-NMOSD) acquired within 1 month of attacks. BSLs were observed in 18 of 61 (30%) participants with AQP4-NMOSD, while none of 49 participants with MOGAD showed BSL (p < 0.001). BSL during the acute phase would be useful to differentiate AQP4-NMOSD from MOGAD.

Original language	English
Pages (from-to)	989-992
Number of pages	4
Journal	Multiple Sclerosis
Volume	28
Issue number	6
DOIs	https://doi.org/10.1177/13524585211060326
State	Published - May 2022

Keywords

aquaporin-4
MRI
myelin oligodendrocyte glycoprotein
Neuromyelitis optica spectrum disorder
spinal cord

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10.1177/13524585211060326

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title = "Brighter spotty lesions on spinal MRI help differentiate AQP4 antibody-positive NMOSD from MOGAD",

abstract = "In a large acute myelitis cohort, we aimed to determine whether brighter spotty lesions (BSLs)—using the refined terminology—on spinal magnetic resonance imaging (MRI) help distinguish aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) from myelin oligodendrocyte glycoprotein antibody disease (MOGAD). An experienced neuro-radiologist and two neurologists independently analyzed 133 spinal MRI scans (65 from MOGAD and 68 from AQP4-NMOSD) acquired within 1 month of attacks. BSLs were observed in 18 of 61 (30\%) participants with AQP4-NMOSD, while none of 49 participants with MOGAD showed BSL (p < 0.001). BSL during the acute phase would be useful to differentiate AQP4-NMOSD from MOGAD.",

keywords = "aquaporin-4, MRI, myelin oligodendrocyte glycoprotein, Neuromyelitis optica spectrum disorder, spinal cord",

author = "Hyun, \{Jae Won\} and Lee, \{Hye Lim\} and Jaehong Park and Jiah Kim and Min, \{Ju Hong\} and Kim, \{Byoung Joon\} and Kim, \{Seung Woo\} and Shin, \{Ha Young\} and Huh, \{So Young\} and Woojun Kim and Seo, \{Ji Won\} and Kim, \{Ki Hoon\} and Kim, \{Su Hyun\} and Kim, \{Ho Jin\}",

note = "Publisher Copyright: {\textcopyright} The Author(s), 2021.",

year = "2022",

month = may,

doi = "10.1177/13524585211060326",

language = "English",

volume = "28",

pages = "989--992",

journal = "Multiple Sclerosis",

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T1 - Brighter spotty lesions on spinal MRI help differentiate AQP4 antibody-positive NMOSD from MOGAD

AU - Hyun, Jae Won

AU - Lee, Hye Lim

AU - Park, Jaehong

AU - Kim, Jiah

AU - Min, Ju Hong

AU - Kim, Byoung Joon

AU - Kim, Seung Woo

AU - Shin, Ha Young

AU - Huh, So Young

AU - Kim, Woojun

AU - Seo, Ji Won

AU - Kim, Ki Hoon

AU - Kim, Su Hyun

AU - Kim, Ho Jin

N1 - Publisher Copyright: © The Author(s), 2021.

PY - 2022/5

Y1 - 2022/5

N2 - In a large acute myelitis cohort, we aimed to determine whether brighter spotty lesions (BSLs)—using the refined terminology—on spinal magnetic resonance imaging (MRI) help distinguish aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) from myelin oligodendrocyte glycoprotein antibody disease (MOGAD). An experienced neuro-radiologist and two neurologists independently analyzed 133 spinal MRI scans (65 from MOGAD and 68 from AQP4-NMOSD) acquired within 1 month of attacks. BSLs were observed in 18 of 61 (30%) participants with AQP4-NMOSD, while none of 49 participants with MOGAD showed BSL (p < 0.001). BSL during the acute phase would be useful to differentiate AQP4-NMOSD from MOGAD.

AB - In a large acute myelitis cohort, we aimed to determine whether brighter spotty lesions (BSLs)—using the refined terminology—on spinal magnetic resonance imaging (MRI) help distinguish aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) from myelin oligodendrocyte glycoprotein antibody disease (MOGAD). An experienced neuro-radiologist and two neurologists independently analyzed 133 spinal MRI scans (65 from MOGAD and 68 from AQP4-NMOSD) acquired within 1 month of attacks. BSLs were observed in 18 of 61 (30%) participants with AQP4-NMOSD, while none of 49 participants with MOGAD showed BSL (p < 0.001). BSL during the acute phase would be useful to differentiate AQP4-NMOSD from MOGAD.

KW - aquaporin-4

KW - MRI

KW - myelin oligodendrocyte glycoprotein

KW - Neuromyelitis optica spectrum disorder

KW - spinal cord

UR - https://www.scopus.com/pages/publications/85120717563

U2 - 10.1177/13524585211060326

DO - 10.1177/13524585211060326

M3 - Article

C2 - 34865555

AN - SCOPUS:85120717563

SN - 1352-4585

VL - 28

SP - 989

EP - 992

JO - Multiple Sclerosis

JF - Multiple Sclerosis

IS - 6

ER -

Brighter spotty lesions on spinal MRI help differentiate AQP4 antibody-positive NMOSD from MOGAD

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Keywords

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