Body mass index threshold for obesity should be personalized based on polygenic score: Analysis of european and east asian biobanks

Min Seo Kim; Injeong Shim; Beomsu Kim; Ron Do; Woong Yang Park; Amit V. Khera; Pradeep Natarajan; Patrick T. Ellinor; Akl C. Fahed; Hong Hee Won

doi:10.1016/j.ajpc.2026.101509

Body mass index threshold for obesity should be personalized based on polygenic score: Analysis of european and east asian biobanks

Min Seo Kim
, Injeong Shim
, Beomsu Kim
, Ron Do
, Woong Yang Park
, Amit V. Khera
, Pradeep Natarajan
, Patrick T. Ellinor
, Akl C. Fahed
, Hong Hee Won

Partners HealthCare
Broad Institute
Sungkyunkwan University
Harvard University
Icahn School of Medicine at Mount Sinai
Verve Therapeutics

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Original language	English
Article number	101509
Journal	American Journal of Preventive Cardiology
Volume	29
DOIs	https://doi.org/10.1016/j.ajpc.2026.101509
State	Accepted/In press - 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Body mass index
Clinical threshold
Obesity
Personalized medicine
Polygenic risk score

Access to Document

10.1016/j.ajpc.2026.101509

Cite this

Kim, M. S., Shim, I., Kim, B., Do, R., Park, W. Y., Khera, A. V., Natarajan, P., Ellinor, P. T., Fahed, A. C., & Won, H. H. (Accepted/In press). Body mass index threshold for obesity should be personalized based on polygenic score: Analysis of european and east asian biobanks. American Journal of Preventive Cardiology, 29, Article 101509. https://doi.org/10.1016/j.ajpc.2026.101509

@article{893bf30f3179460da8edcbee4698d123,

title = "Body mass index threshold for obesity should be personalized based on polygenic score: Analysis of european and east asian biobanks",

keywords = "Body mass index, Clinical threshold, Obesity, Personalized medicine, Polygenic risk score",

author = "Kim, \{Min Seo\} and Injeong Shim and Beomsu Kim and Ron Do and Park, \{Woong Yang\} and Khera, \{Amit V.\} and Pradeep Natarajan and Ellinor, \{Patrick T.\} and Fahed, \{Akl C.\} and Won, \{Hong Hee\}",

year = "2026",

doi = "10.1016/j.ajpc.2026.101509",

language = "English",

volume = "29",

journal = "American Journal of Preventive Cardiology",

issn = "2666-6677",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Body mass index threshold for obesity should be personalized based on polygenic score

T2 - Analysis of european and east asian biobanks

AU - Kim, Min Seo

AU - Shim, Injeong

AU - Kim, Beomsu

AU - Do, Ron

AU - Park, Woong Yang

AU - Khera, Amit V.

AU - Natarajan, Pradeep

AU - Ellinor, Patrick T.

AU - Fahed, Akl C.

AU - Won, Hong Hee

PY - 2026

Y1 - 2026

KW - Body mass index

KW - Clinical threshold

KW - Obesity

KW - Personalized medicine

KW - Polygenic risk score

UR - https://www.scopus.com/pages/publications/105033912153

U2 - 10.1016/j.ajpc.2026.101509

DO - 10.1016/j.ajpc.2026.101509

M3 - Article

AN - SCOPUS:105033912153

SN - 2666-6677

VL - 29

JO - American Journal of Preventive Cardiology

JF - American Journal of Preventive Cardiology

M1 - 101509

ER -

Body mass index threshold for obesity should be personalized based on polygenic score: Analysis of european and east asian biobanks

UN SDGs

Keywords

Access to Document

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Cite this