TY - JOUR
T1 - Biphenyls from Berberis koreana
AU - Kim, Ki Hyun
AU - Choi, Sang Un
AU - Ha, Sang Keun
AU - Kim, Sun Yeou
AU - Lee, Kang Ro
PY - 2009/11/30
Y1 - 2009/11/30
N2 - Three new biphenyls, berbekorin A (1), 2′-hydroxy-3,4,5- trimethoxybiphenyl (2), and 4,5-dihydroxy-3-methoxybiphenyl (3), together with 11 known biphenyls (4-14), were isolated from the n-hexane-soluble fraction of the MeOH extract of the trunk of Berberis koreana. The structures of 1-3 were determined by spectroscopic methods, including 1D and 2D NMR analysis. Compound 1 exhibited cytotoxic activity against the SK-MEL-2 skin melanoma cell line, in particular. Moreover, compounds 2, 5, 6, and 14 inhibited NO production in LPS-activated BV-2 cells, a microglial cell line.
AB - Three new biphenyls, berbekorin A (1), 2′-hydroxy-3,4,5- trimethoxybiphenyl (2), and 4,5-dihydroxy-3-methoxybiphenyl (3), together with 11 known biphenyls (4-14), were isolated from the n-hexane-soluble fraction of the MeOH extract of the trunk of Berberis koreana. The structures of 1-3 were determined by spectroscopic methods, including 1D and 2D NMR analysis. Compound 1 exhibited cytotoxic activity against the SK-MEL-2 skin melanoma cell line, in particular. Moreover, compounds 2, 5, 6, and 14 inhibited NO production in LPS-activated BV-2 cells, a microglial cell line.
UR - https://www.scopus.com/pages/publications/73349126124
U2 - 10.1021/np900460j
DO - 10.1021/np900460j
M3 - Comment/debate
C2 - 19813743
AN - SCOPUS:73349126124
SN - 0163-3864
VL - 72
SP - 2061
EP - 2064
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 11
ER -
