Biological evaluation of phenolic constituents from the trunk of Berberis koreana

Ki Hyun Kim; Eunjung Moon; Sang Un Choi; Sun Yeou Kim; Kang Ro Lee

doi:10.1016/j.bmcl.2011.02.104

Biological evaluation of phenolic constituents from the trunk of Berberis koreana

Ki Hyun Kim, Eunjung Moon, Sang Un Choi, Sun Yeou Kim, Kang Ro Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A bioassay-guided fractionation and chemical investigation of the trunk of Berberis koreana resulted in the isolation and identification of a new sesquilignan, named berbikonol (1), along with fourteen known lignan derivatives (2-15) and a new phenolic compound, named berfussinol (16), together with five known ones (17-21). The structures of these new compounds were elucidated on the basis of 1D and 2D NMR spectroscopic data analysis as well as circular dichroism (CD) spectroscopy studies. Compounds 1-5, 7-8, 11, and 14 showed significant cytotoxicity against the XF498 cell line with IC₅₀ values of 7.14-19.32 μM. In addition, compounds 3-8 and 15 strongly reduced nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells, a microglial cell line.

Original language	English
Pages (from-to)	2270-2273
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	8
DOIs	https://doi.org/10.1016/j.bmcl.2011.02.104
State	Published - 15 Apr 2011

Keywords

Berberidaceae
Berberis koreana
Cytotoxicity
Neuroinflammation
Phenolic

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10.1016/j.bmcl.2011.02.104

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title = "Biological evaluation of phenolic constituents from the trunk of Berberis koreana",

abstract = "A bioassay-guided fractionation and chemical investigation of the trunk of Berberis koreana resulted in the isolation and identification of a new sesquilignan, named berbikonol (1), along with fourteen known lignan derivatives (2-15) and a new phenolic compound, named berfussinol (16), together with five known ones (17-21). The structures of these new compounds were elucidated on the basis of 1D and 2D NMR spectroscopic data analysis as well as circular dichroism (CD) spectroscopy studies. Compounds 1-5, 7-8, 11, and 14 showed significant cytotoxicity against the XF498 cell line with IC50 values of 7.14-19.32 μM. In addition, compounds 3-8 and 15 strongly reduced nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells, a microglial cell line.",

keywords = "Berberidaceae, Berberis koreana, Cytotoxicity, Neuroinflammation, Phenolic",

author = "Kim, \{Ki Hyun\} and Eunjung Moon and Choi, \{Sang Un\} and Kim, \{Sun Yeou\} and Lee, \{Kang Ro\}",

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doi = "10.1016/j.bmcl.2011.02.104",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Biological evaluation of phenolic constituents from the trunk of Berberis koreana

AU - Kim, Ki Hyun

AU - Moon, Eunjung

AU - Choi, Sang Un

AU - Kim, Sun Yeou

AU - Lee, Kang Ro

PY - 2011/4/15

Y1 - 2011/4/15

N2 - A bioassay-guided fractionation and chemical investigation of the trunk of Berberis koreana resulted in the isolation and identification of a new sesquilignan, named berbikonol (1), along with fourteen known lignan derivatives (2-15) and a new phenolic compound, named berfussinol (16), together with five known ones (17-21). The structures of these new compounds were elucidated on the basis of 1D and 2D NMR spectroscopic data analysis as well as circular dichroism (CD) spectroscopy studies. Compounds 1-5, 7-8, 11, and 14 showed significant cytotoxicity against the XF498 cell line with IC50 values of 7.14-19.32 μM. In addition, compounds 3-8 and 15 strongly reduced nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells, a microglial cell line.

AB - A bioassay-guided fractionation and chemical investigation of the trunk of Berberis koreana resulted in the isolation and identification of a new sesquilignan, named berbikonol (1), along with fourteen known lignan derivatives (2-15) and a new phenolic compound, named berfussinol (16), together with five known ones (17-21). The structures of these new compounds were elucidated on the basis of 1D and 2D NMR spectroscopic data analysis as well as circular dichroism (CD) spectroscopy studies. Compounds 1-5, 7-8, 11, and 14 showed significant cytotoxicity against the XF498 cell line with IC50 values of 7.14-19.32 μM. In addition, compounds 3-8 and 15 strongly reduced nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells, a microglial cell line.

KW - Berberidaceae

KW - Berberis koreana

KW - Cytotoxicity

KW - Neuroinflammation

KW - Phenolic

UR - https://www.scopus.com/pages/publications/79953282217

U2 - 10.1016/j.bmcl.2011.02.104

DO - 10.1016/j.bmcl.2011.02.104

M3 - Article

C2 - 21420296

AN - SCOPUS:79953282217

SN - 0960-894X

VL - 21

SP - 2270

EP - 2273

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

Biological evaluation of phenolic constituents from the trunk of Berberis koreana

Abstract

Keywords

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