Bioderived polyelectrolyte nanogels for robust antigen loading and vaccine adjuvant effects

Yong Taik Lim; Sang Mu Shim; Young Woock Noh; Kyung Soon Lee; Doo Yeol Choi; Hiroshi Uyama; Hee Ho Bae; Ji Hyun Kim; Kwan Soo Hong; Moon Hee Sung; Haryoung Poo

doi:10.1002/smll.201101836

Bioderived polyelectrolyte nanogels for robust antigen loading and vaccine adjuvant effects

Yong Taik Lim
, Sang Mu Shim
, Young Woock Noh
, Kyung Soon Lee
, Doo Yeol Choi
, Hiroshi Uyama
, Hee Ho Bae
, Ji Hyun Kim
, Kwan Soo Hong
, Moon Hee Sung
, Haryoung Poo

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

An easy but robust strategy for the synthesis of bioderived polyelectrolyte nanogels for protein antigen loading and vaccine adjuvant systems that can improve both humoral (Th2) and cellular immunity (Th1) is presented. The synthesized polyelectrolyte nanogels promote the uptake of antigens into antigen-presenting cells and strongly induce ovalbumin-specific INF-γ producing cells, cytotoxic T cell activity, and antibody production.

Original language	English
Pages (from-to)	3281-3286
Number of pages	6
Journal	Small
Volume	7
Issue number	23
DOIs	https://doi.org/10.1002/smll.201101836
State	Published - 2 Dec 2011
Externally published	Yes

Keywords

antigens
dendritic cells
drug delivery
polyelectrolyte nanogels
vaccine adjuvant

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10.1002/smll.201101836

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title = "Bioderived polyelectrolyte nanogels for robust antigen loading and vaccine adjuvant effects",

abstract = "An easy but robust strategy for the synthesis of bioderived polyelectrolyte nanogels for protein antigen loading and vaccine adjuvant systems that can improve both humoral (Th2) and cellular immunity (Th1) is presented. The synthesized polyelectrolyte nanogels promote the uptake of antigens into antigen-presenting cells and strongly induce ovalbumin-specific INF-γ producing cells, cytotoxic T cell activity, and antibody production.",

keywords = "antigens, dendritic cells, drug delivery, polyelectrolyte nanogels, vaccine adjuvant",

author = "Lim, \{Yong Taik\} and Shim, \{Sang Mu\} and Noh, \{Young Woock\} and Lee, \{Kyung Soon\} and Choi, \{Doo Yeol\} and Hiroshi Uyama and Bae, \{Hee Ho\} and Kim, \{Ji Hyun\} and Hong, \{Kwan Soo\} and Sung, \{Moon Hee\} and Haryoung Poo",

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doi = "10.1002/smll.201101836",

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T1 - Bioderived polyelectrolyte nanogels for robust antigen loading and vaccine adjuvant effects

AU - Lim, Yong Taik

AU - Shim, Sang Mu

AU - Noh, Young Woock

AU - Lee, Kyung Soon

AU - Choi, Doo Yeol

AU - Uyama, Hiroshi

AU - Bae, Hee Ho

AU - Kim, Ji Hyun

AU - Hong, Kwan Soo

AU - Sung, Moon Hee

AU - Poo, Haryoung

PY - 2011/12/2

Y1 - 2011/12/2

N2 - An easy but robust strategy for the synthesis of bioderived polyelectrolyte nanogels for protein antigen loading and vaccine adjuvant systems that can improve both humoral (Th2) and cellular immunity (Th1) is presented. The synthesized polyelectrolyte nanogels promote the uptake of antigens into antigen-presenting cells and strongly induce ovalbumin-specific INF-γ producing cells, cytotoxic T cell activity, and antibody production.

AB - An easy but robust strategy for the synthesis of bioderived polyelectrolyte nanogels for protein antigen loading and vaccine adjuvant systems that can improve both humoral (Th2) and cellular immunity (Th1) is presented. The synthesized polyelectrolyte nanogels promote the uptake of antigens into antigen-presenting cells and strongly induce ovalbumin-specific INF-γ producing cells, cytotoxic T cell activity, and antibody production.

KW - antigens

KW - dendritic cells

KW - drug delivery

KW - polyelectrolyte nanogels

KW - vaccine adjuvant

UR - https://www.scopus.com/pages/publications/82555171578

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DO - 10.1002/smll.201101836

M3 - Article

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AN - SCOPUS:82555171578

SN - 1613-6810

VL - 7

SP - 3281

EP - 3286

JO - Small

JF - Small

IS - 23

ER -

Bioderived polyelectrolyte nanogels for robust antigen loading and vaccine adjuvant effects

Abstract

Keywords

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