Biodegradable sheath-core biphasic monofilament braided stent for bio-functional treatment of esophageal strictures

Cheol Min Han; Eugene Lih; Seul Ki Choi; Tarek M. Bedair; Young Jae Lee; Wooram Park; Dong Keun Han; Jun Sik Son; Yoon Ki Joung

doi:10.1016/j.jiec.2018.07.014

Biodegradable sheath-core biphasic monofilament braided stent for bio-functional treatment of esophageal strictures

Cheol Min Han
, Eugene Lih
, Seul Ki Choi
, Tarek M. Bedair
, Young Jae Lee
, Wooram Park
, Dong Keun Han
, Jun Sik Son
, Yoon Ki Joung

Korea Institute of Science and Technology
Jeonju University
Minia University
S&G Biotech Inc.
CHA University
Korea Textile Development Institute
University of Science and Technology UST

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

In this study, a polydioxanone (PDO) and poly(L-lactic acid) (PLLA) sheath-core biphasic monofilament was designed to develop an esophageal stent with improved mechanical properties and controlled biodegradability. The radial force of PDO/PLLA sheath-core stent was 10.24 N, while that of PDO stent was 5.64 N. Deteriorations of tensile strength, elastic modulus and elongation during degradation test were also delayed on PDO/PLLA group. Hyaluronic acid–dopamine conjugate and BaSO₄/PDO conjugate coating layers provided improved tissue adhesion strength and reasonable X-ray contrast, respectively. Taken all together, the sheath-core filaments with tissue adhesive and radiopaque properties will be useful in designing esophageal stents.

Original language	English
Pages (from-to)	396-406
Number of pages	11
Journal	Journal of Industrial and Engineering Chemistry
Volume	67
DOIs	https://doi.org/10.1016/j.jiec.2018.07.014
State	Published - 25 Nov 2018
Externally published	Yes

Keywords

Esophageal stent
Poly(L-lactic acid)
Polydioxanone
Sheath-core monofilament
Surface treatments

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10.1016/j.jiec.2018.07.014

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@article{75649076259b44148f684affe32d8a06,

title = "Biodegradable sheath-core biphasic monofilament braided stent for bio-functional treatment of esophageal strictures",

abstract = "In this study, a polydioxanone (PDO) and poly(L-lactic acid) (PLLA) sheath-core biphasic monofilament was designed to develop an esophageal stent with improved mechanical properties and controlled biodegradability. The radial force of PDO/PLLA sheath-core stent was 10.24 N, while that of PDO stent was 5.64 N. Deteriorations of tensile strength, elastic modulus and elongation during degradation test were also delayed on PDO/PLLA group. Hyaluronic acid–dopamine conjugate and BaSO4/PDO conjugate coating layers provided improved tissue adhesion strength and reasonable X-ray contrast, respectively. Taken all together, the sheath-core filaments with tissue adhesive and radiopaque properties will be useful in designing esophageal stents.",

keywords = "Esophageal stent, Poly(L-lactic acid), Polydioxanone, Sheath-core monofilament, Surface treatments",

author = "Han, \{Cheol Min\} and Eugene Lih and Choi, \{Seul Ki\} and Bedair, \{Tarek M.\} and Lee, \{Young Jae\} and Wooram Park and Han, \{Dong Keun\} and Son, \{Jun Sik\} and Joung, \{Yoon Ki\}",

note = "Publisher Copyright: {\textcopyright} 2018 The Korean Society of Industrial and Engineering Chemistry",

year = "2018",

month = nov,

day = "25",

doi = "10.1016/j.jiec.2018.07.014",

language = "English",

volume = "67",

pages = "396--406",

journal = "Journal of Industrial and Engineering Chemistry",

issn = "1226-086X",

publisher = "Korean Society of Industrial Engineering Chemistry",

}

TY - JOUR

T1 - Biodegradable sheath-core biphasic monofilament braided stent for bio-functional treatment of esophageal strictures

AU - Han, Cheol Min

AU - Lih, Eugene

AU - Choi, Seul Ki

AU - Bedair, Tarek M.

AU - Lee, Young Jae

AU - Park, Wooram

AU - Han, Dong Keun

AU - Son, Jun Sik

AU - Joung, Yoon Ki

PY - 2018/11/25

Y1 - 2018/11/25

N2 - In this study, a polydioxanone (PDO) and poly(L-lactic acid) (PLLA) sheath-core biphasic monofilament was designed to develop an esophageal stent with improved mechanical properties and controlled biodegradability. The radial force of PDO/PLLA sheath-core stent was 10.24 N, while that of PDO stent was 5.64 N. Deteriorations of tensile strength, elastic modulus and elongation during degradation test were also delayed on PDO/PLLA group. Hyaluronic acid–dopamine conjugate and BaSO4/PDO conjugate coating layers provided improved tissue adhesion strength and reasonable X-ray contrast, respectively. Taken all together, the sheath-core filaments with tissue adhesive and radiopaque properties will be useful in designing esophageal stents.

AB - In this study, a polydioxanone (PDO) and poly(L-lactic acid) (PLLA) sheath-core biphasic monofilament was designed to develop an esophageal stent with improved mechanical properties and controlled biodegradability. The radial force of PDO/PLLA sheath-core stent was 10.24 N, while that of PDO stent was 5.64 N. Deteriorations of tensile strength, elastic modulus and elongation during degradation test were also delayed on PDO/PLLA group. Hyaluronic acid–dopamine conjugate and BaSO4/PDO conjugate coating layers provided improved tissue adhesion strength and reasonable X-ray contrast, respectively. Taken all together, the sheath-core filaments with tissue adhesive and radiopaque properties will be useful in designing esophageal stents.

KW - Esophageal stent

KW - Poly(L-lactic acid)

KW - Polydioxanone

KW - Sheath-core monofilament

KW - Surface treatments

UR - https://www.scopus.com/pages/publications/85050402348

U2 - 10.1016/j.jiec.2018.07.014

DO - 10.1016/j.jiec.2018.07.014

M3 - Article

AN - SCOPUS:85050402348

SN - 1226-086X

VL - 67

SP - 396

EP - 406

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

ER -

Biodegradable sheath-core biphasic monofilament braided stent for bio-functional treatment of esophageal strictures

Abstract

Keywords

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