Aven overexpression: Association with poor prognosis in childhood acute lymphoblastic leukemia

Jaewon Choi; Yu Kyeong Hwang; Ki Woong Sung; Dong Hyun Kim; Keon Hee Yoo; Hye Lim Jung; Hong Hoe Koo

doi:10.1016/j.leukres.2005.11.001

Aven overexpression: Association with poor prognosis in childhood acute lymphoblastic leukemia

Jaewon Choi
, Yu Kyeong Hwang
, Ki Woong Sung
, Dong Hyun Kim
, Keon Hee Yoo
, Hye Lim Jung
, Hong Hoe Koo

Department of Pediatrics

MOGAM Biotechnology Research Institute

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Aven expression has recently been identified as an anti-apoptotic protein. In this study, Aven expression in 91 children with acute lymphoblastic leukemia (ALL) was investigated for possible correlation with clinical features at diagnosis and treatment outcome. Aven expression was found to be higher in patients ≥10 years old or <1 year (P = 0.003), and in patients with unfavorable cytogenetic abnormalities (P < 0.001). Aven expression was also significantly higher in relapsed patients in the standard-risk group. Aven overexpression was an independent poor prognostic factor. These findings demonstrate that Aven expression can predict prognosis in childhood ALL.

Original language	English
Pages (from-to)	1019-1025
Number of pages	7
Journal	Leukemia Research
Volume	30
Issue number	8
DOIs	https://doi.org/10.1016/j.leukres.2005.11.001
State	Published - Aug 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute lymphoblastic leukemia
Apoptosis
Aven
Children
Prognostic factors
Quantitative RT-PCR

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10.1016/j.leukres.2005.11.001

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title = "Aven overexpression: Association with poor prognosis in childhood acute lymphoblastic leukemia",

abstract = "Aven expression has recently been identified as an anti-apoptotic protein. In this study, Aven expression in 91 children with acute lymphoblastic leukemia (ALL) was investigated for possible correlation with clinical features at diagnosis and treatment outcome. Aven expression was found to be higher in patients ≥10 years old or <1 year (P = 0.003), and in patients with unfavorable cytogenetic abnormalities (P < 0.001). Aven expression was also significantly higher in relapsed patients in the standard-risk group. Aven overexpression was an independent poor prognostic factor. These findings demonstrate that Aven expression can predict prognosis in childhood ALL.",

keywords = "Acute lymphoblastic leukemia, Apoptosis, Aven, Children, Prognostic factors, Quantitative RT-PCR",

author = "Jaewon Choi and Hwang, \{Yu Kyeong\} and Sung, \{Ki Woong\} and Kim, \{Dong Hyun\} and Yoo, \{Keon Hee\} and Jung, \{Hye Lim\} and Koo, \{Hong Hoe\}",

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doi = "10.1016/j.leukres.2005.11.001",

language = "English",

volume = "30",

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journal = "Leukemia Research",

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TY - JOUR

T1 - Aven overexpression

T2 - Association with poor prognosis in childhood acute lymphoblastic leukemia

AU - Choi, Jaewon

AU - Hwang, Yu Kyeong

AU - Sung, Ki Woong

AU - Kim, Dong Hyun

AU - Yoo, Keon Hee

AU - Jung, Hye Lim

AU - Koo, Hong Hoe

PY - 2006/8

Y1 - 2006/8

N2 - Aven expression has recently been identified as an anti-apoptotic protein. In this study, Aven expression in 91 children with acute lymphoblastic leukemia (ALL) was investigated for possible correlation with clinical features at diagnosis and treatment outcome. Aven expression was found to be higher in patients ≥10 years old or <1 year (P = 0.003), and in patients with unfavorable cytogenetic abnormalities (P < 0.001). Aven expression was also significantly higher in relapsed patients in the standard-risk group. Aven overexpression was an independent poor prognostic factor. These findings demonstrate that Aven expression can predict prognosis in childhood ALL.

AB - Aven expression has recently been identified as an anti-apoptotic protein. In this study, Aven expression in 91 children with acute lymphoblastic leukemia (ALL) was investigated for possible correlation with clinical features at diagnosis and treatment outcome. Aven expression was found to be higher in patients ≥10 years old or <1 year (P = 0.003), and in patients with unfavorable cytogenetic abnormalities (P < 0.001). Aven expression was also significantly higher in relapsed patients in the standard-risk group. Aven overexpression was an independent poor prognostic factor. These findings demonstrate that Aven expression can predict prognosis in childhood ALL.

KW - Acute lymphoblastic leukemia

KW - Apoptosis

KW - Aven

KW - Children

KW - Prognostic factors

KW - Quantitative RT-PCR

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DO - 10.1016/j.leukres.2005.11.001

M3 - Article

C2 - 16388850

AN - SCOPUS:33744783955

SN - 0145-2126

VL - 30

SP - 1019

EP - 1025

JO - Leukemia Research

JF - Leukemia Research

IS - 8

ER -

Aven overexpression: Association with poor prognosis in childhood acute lymphoblastic leukemia

Abstract

UN SDGs

Keywords

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