Autologous mesenchymal stem cell therapy in patients with stroke

Oh Young Bang

doi:10.1007/978-3-319-15063-5_3

Autologous mesenchymal stem cell therapy in patients with stroke

Oh Young Bang

Department of Neurology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Cell therapy is an emerging paradigm in the stroke treatment field and is considered a potential regenerative strategy for patients with fixed neurologic deficits. Various cell types have been used to improve function and recovery after stroke, including embryonic stem cells, immortalized pluripotent stem cells, neural stem/progenitor cells, mononuclear cells, cell lines, and non-neuronal adult stem cells, such as mesenchymal stem cells (MSCs). This review will focus on the clinical applications of adult stem cell therapy, in particular, the use of autologous MSCs in stroke patients. The results of clinical trials, including the stem cell Application Research and Trials In NeuroloGy (STARTING) trial, are summarized together with the ongoing clinical trials of MSC therapy in adult stroke patients. In addition, the strategies to improve the therapeutic efficacy of MSCs that meet the FDA's regulations on stem cell use for clinical applications will be discussed, from bench (diverse cell sources and culture processes) to bedside (patient selection, blood-brain barrier manipulation, and outcome measures).

Original language	English
Title of host publication	Cell Therapy for Brain Injury
Publisher	Springer International Publishing
Pages	21-35
Number of pages	15
ISBN (Electronic)	9783319150635
ISBN (Print)	9783319150628
DOIs	https://doi.org/10.1007/978-3-319-15063-5_3
State	Published - 1 Jan 2015

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10.1007/978-3-319-15063-5_3

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abstract = "Cell therapy is an emerging paradigm in the stroke treatment field and is considered a potential regenerative strategy for patients with fixed neurologic deficits. Various cell types have been used to improve function and recovery after stroke, including embryonic stem cells, immortalized pluripotent stem cells, neural stem/progenitor cells, mononuclear cells, cell lines, and non-neuronal adult stem cells, such as mesenchymal stem cells (MSCs). This review will focus on the clinical applications of adult stem cell therapy, in particular, the use of autologous MSCs in stroke patients. The results of clinical trials, including the stem cell Application Research and Trials In NeuroloGy (STARTING) trial, are summarized together with the ongoing clinical trials of MSC therapy in adult stroke patients. In addition, the strategies to improve the therapeutic efficacy of MSCs that meet the FDA's regulations on stem cell use for clinical applications will be discussed, from bench (diverse cell sources and culture processes) to bedside (patient selection, blood-brain barrier manipulation, and outcome measures).",

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AB - Cell therapy is an emerging paradigm in the stroke treatment field and is considered a potential regenerative strategy for patients with fixed neurologic deficits. Various cell types have been used to improve function and recovery after stroke, including embryonic stem cells, immortalized pluripotent stem cells, neural stem/progenitor cells, mononuclear cells, cell lines, and non-neuronal adult stem cells, such as mesenchymal stem cells (MSCs). This review will focus on the clinical applications of adult stem cell therapy, in particular, the use of autologous MSCs in stroke patients. The results of clinical trials, including the stem cell Application Research and Trials In NeuroloGy (STARTING) trial, are summarized together with the ongoing clinical trials of MSC therapy in adult stroke patients. In addition, the strategies to improve the therapeutic efficacy of MSCs that meet the FDA's regulations on stem cell use for clinical applications will be discussed, from bench (diverse cell sources and culture processes) to bedside (patient selection, blood-brain barrier manipulation, and outcome measures).

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Autologous mesenchymal stem cell therapy in patients with stroke

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