Asymmetric total synthesis of (S)-dapoxetine

Sun Joo Kim; Tae Hong Jeon; Im Sook Min; In Su Kim; Young Hoon Jung

doi:10.1016/j.tetlet.2012.05.037

Asymmetric total synthesis of (S)-dapoxetine

Sun Joo Kim, Tae Hong Jeon, Im Sook Min, In Su Kim, Young Hoon Jung

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

A concise asymmetric total synthesis of (S)-dapoxetine from commercially available 3-chloropropiophenone is described. The key step includes a highly stereoselective amination of chiral benzylic ether, with the retention of stereochemistry, using chlorosulfonyl isocyanate.

Original language	English
Pages (from-to)	3680-3682
Number of pages	3
Journal	Tetrahedron Letters
Volume	53
Issue number	28
DOIs	https://doi.org/10.1016/j.tetlet.2012.05.037
State	Published - 11 Jul 2012
Externally published	Yes

Keywords

Amination
Asymmetric
Chlorosulfonyl isocyanate
Dapoxetine

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10.1016/j.tetlet.2012.05.037

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@article{13491346fca548628f97a4f4e068f524,

title = "Asymmetric total synthesis of (S)-dapoxetine",

abstract = "A concise asymmetric total synthesis of (S)-dapoxetine from commercially available 3-chloropropiophenone is described. The key step includes a highly stereoselective amination of chiral benzylic ether, with the retention of stereochemistry, using chlorosulfonyl isocyanate.",

keywords = "Amination, Asymmetric, Chlorosulfonyl isocyanate, Dapoxetine",

author = "Kim, \{Sun Joo\} and Jeon, \{Tae Hong\} and Min, \{Im Sook\} and Kim, \{In Su\} and Jung, \{Young Hoon\}",

year = "2012",

month = jul,

day = "11",

doi = "10.1016/j.tetlet.2012.05.037",

language = "English",

volume = "53",

pages = "3680--3682",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "28",

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TY - JOUR

T1 - Asymmetric total synthesis of (S)-dapoxetine

AU - Kim, Sun Joo

AU - Jeon, Tae Hong

AU - Min, Im Sook

AU - Kim, In Su

AU - Jung, Young Hoon

PY - 2012/7/11

Y1 - 2012/7/11

N2 - A concise asymmetric total synthesis of (S)-dapoxetine from commercially available 3-chloropropiophenone is described. The key step includes a highly stereoselective amination of chiral benzylic ether, with the retention of stereochemistry, using chlorosulfonyl isocyanate.

AB - A concise asymmetric total synthesis of (S)-dapoxetine from commercially available 3-chloropropiophenone is described. The key step includes a highly stereoselective amination of chiral benzylic ether, with the retention of stereochemistry, using chlorosulfonyl isocyanate.

KW - Amination

KW - Asymmetric

KW - Chlorosulfonyl isocyanate

KW - Dapoxetine

UR - https://www.scopus.com/pages/publications/84861997187

U2 - 10.1016/j.tetlet.2012.05.037

DO - 10.1016/j.tetlet.2012.05.037

M3 - Article

AN - SCOPUS:84861997187

SN - 0040-4039

VL - 53

SP - 3680

EP - 3682

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 28

ER -

Asymmetric total synthesis of (S)-dapoxetine

Abstract

Keywords

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