Asymmetric synthesis and evaluation of α-quaternary chiral lactam derivatives as novel anticancer agents

Hwanhyuk Lee; Su Jung Hwang; Jisung Jung; Suckchang Hong; Myungmo Lee; Hyeung Geun Park; Hyo Jong Lee; Yohan Park

doi:10.1007/s12272-013-0274-4

Asymmetric synthesis and evaluation of α-quaternary chiral lactam derivatives as novel anticancer agents

Hwanhyuk Lee
, Su Jung Hwang
, Jisung Jung
, Suckchang Hong
, Myungmo Lee
, Hyeung Geun Park
, Hyo Jong Lee
, Yohan Park

Inje University
Seoul National University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Asymmetric synthesis of α-quaternary chiral lactam derivatives as novel anticancer agents and evaluation of their cytotoxic potentials and spectrums are reported. Among the developed lactam derivatives, the most active new compounds (S)-4m and (S)-4n synthesized via asymmetric phase-transfer catalytic alkylation in very high optical yields (98 % ee) show promising in vitro anticancer activities with low micromolar IC₅₀ values against colon, uterus, lung, and breast human cancer cells.

Original language	English
Pages (from-to)	1264-1270
Number of pages	7
Journal	Archives of Pharmacal Research
Volume	37
Issue number	10
DOIs	https://doi.org/10.1007/s12272-013-0274-4
State	Published - 1 Oct 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer activity
Breast cancers
Colon
Lung
Phase-transfer catalytic alkylation
α-Quaternary chiral lactam

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10.1007/s12272-013-0274-4

Cite this

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title = "Asymmetric synthesis and evaluation of α-quaternary chiral lactam derivatives as novel anticancer agents",

abstract = "Asymmetric synthesis of α-quaternary chiral lactam derivatives as novel anticancer agents and evaluation of their cytotoxic potentials and spectrums are reported. Among the developed lactam derivatives, the most active new compounds (S)-4m and (S)-4n synthesized via asymmetric phase-transfer catalytic alkylation in very high optical yields (98 \% ee) show promising in vitro anticancer activities with low micromolar IC50 values against colon, uterus, lung, and breast human cancer cells.",

keywords = "Anticancer activity, Breast cancers, Colon, Lung, Phase-transfer catalytic alkylation, α-Quaternary chiral lactam",

author = "Hwanhyuk Lee and Hwang, \{Su Jung\} and Jisung Jung and Suckchang Hong and Myungmo Lee and Park, \{Hyeung Geun\} and Lee, \{Hyo Jong\} and Yohan Park",

note = "Publisher Copyright: {\textcopyright} 2013 The Pharmaceutical Society of Korea.",

year = "2014",

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doi = "10.1007/s12272-013-0274-4",

language = "English",

volume = "37",

pages = "1264--1270",

journal = "Archives of Pharmacal Research",

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T1 - Asymmetric synthesis and evaluation of α-quaternary chiral lactam derivatives as novel anticancer agents

AU - Lee, Hwanhyuk

AU - Hwang, Su Jung

AU - Jung, Jisung

AU - Hong, Suckchang

AU - Lee, Myungmo

AU - Park, Hyeung Geun

AU - Lee, Hyo Jong

AU - Park, Yohan

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Asymmetric synthesis of α-quaternary chiral lactam derivatives as novel anticancer agents and evaluation of their cytotoxic potentials and spectrums are reported. Among the developed lactam derivatives, the most active new compounds (S)-4m and (S)-4n synthesized via asymmetric phase-transfer catalytic alkylation in very high optical yields (98 % ee) show promising in vitro anticancer activities with low micromolar IC50 values against colon, uterus, lung, and breast human cancer cells.

AB - Asymmetric synthesis of α-quaternary chiral lactam derivatives as novel anticancer agents and evaluation of their cytotoxic potentials and spectrums are reported. Among the developed lactam derivatives, the most active new compounds (S)-4m and (S)-4n synthesized via asymmetric phase-transfer catalytic alkylation in very high optical yields (98 % ee) show promising in vitro anticancer activities with low micromolar IC50 values against colon, uterus, lung, and breast human cancer cells.

KW - Anticancer activity

KW - Breast cancers

KW - Colon

KW - Lung

KW - Phase-transfer catalytic alkylation

KW - α-Quaternary chiral lactam

UR - https://www.scopus.com/pages/publications/84938876526

U2 - 10.1007/s12272-013-0274-4

DO - 10.1007/s12272-013-0274-4

M3 - Article

C2 - 24185506

AN - SCOPUS:84938876526

SN - 0253-6269

VL - 37

SP - 1264

EP - 1270

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 10

ER -

Asymmetric synthesis and evaluation of α-quaternary chiral lactam derivatives as novel anticancer agents

Abstract

UN SDGs

Keywords

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