TY - JOUR
T1 - Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea
AU - Kang, Eun Seok
AU - Kim, Myoung Soo
AU - Kim, Chul Hoon
AU - Nam, Chung Mo
AU - Han, Seung Jin
AU - Hur, Kyu Yeon
AU - Ahn, Chul Woo
AU - Cha, Bong Soo
AU - Kim, Soon Il
AU - Lee, Hyun Chul
AU - Kim, Yu Seun
PY - 2009/9/15
Y1 - 2009/9/15
N2 - Background. Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Recent genome-wide association studies have identified several genes associated with type 2 diabetes. Here, we examined the association between PTDM and 17 single nucleotide polymorphisms (SNPs) located within 15 genes in a cohort of renal allograft recipients in Korea. Materials and Methods. A total of 589 patients who received kidney transplants between 1989 and 2007, without a history of diabetes and had a pretransplant fasting glucose less than. 5.5 mmol/L were included in this study. We analyzed the association between the PTDM development and the following SNPs: TCF7L2 rs7903146, SLC30A8 rsl3266634, HHEX (rs1111875, rs7923837, and rs5015480), CDKAL1 rs10946398, CDKN2A/B rs10811661, IGF2BP2 rs4402960, FTO rs8050136, WFS1 rs734312, JAZF1 rs864745, CDC123/CAMK1D rs12779790, TSPAN8 rs7961581, THADA rs7578597, ADAMTS9 rs4607103, NOTCH2 rs1092391, and KCNQ1 rs2237892. Results. Eight SNPs in six genes were significantly associated with the PTDM development: TCF7L2 rs7903146 (odds ratio [OR]=2.20, P=0.016), SLC30A8 rsl.3266634 (OR=1.52, P=0.003), HHEX rs1111875 (OR=1.47, P=0.007), HHEX rs7923837 (OR=2.32, P=0.014), HHEX rs5015480 (OR= 1.59, P=0.003), CDKAL1 rs10946398 (OR= 1.43, P=0.008), CDKN2A/B rs10811661 (OR= 1.33, P=0.039), and KCNQ1 rs2237892 (OR=1.46, P=0.009). Conclusions. These data suggest that genetic variations in TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, and KCNQ1 are associated with PTDM in Korea.
AB - Background. Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Recent genome-wide association studies have identified several genes associated with type 2 diabetes. Here, we examined the association between PTDM and 17 single nucleotide polymorphisms (SNPs) located within 15 genes in a cohort of renal allograft recipients in Korea. Materials and Methods. A total of 589 patients who received kidney transplants between 1989 and 2007, without a history of diabetes and had a pretransplant fasting glucose less than. 5.5 mmol/L were included in this study. We analyzed the association between the PTDM development and the following SNPs: TCF7L2 rs7903146, SLC30A8 rsl3266634, HHEX (rs1111875, rs7923837, and rs5015480), CDKAL1 rs10946398, CDKN2A/B rs10811661, IGF2BP2 rs4402960, FTO rs8050136, WFS1 rs734312, JAZF1 rs864745, CDC123/CAMK1D rs12779790, TSPAN8 rs7961581, THADA rs7578597, ADAMTS9 rs4607103, NOTCH2 rs1092391, and KCNQ1 rs2237892. Results. Eight SNPs in six genes were significantly associated with the PTDM development: TCF7L2 rs7903146 (odds ratio [OR]=2.20, P=0.016), SLC30A8 rsl.3266634 (OR=1.52, P=0.003), HHEX rs1111875 (OR=1.47, P=0.007), HHEX rs7923837 (OR=2.32, P=0.014), HHEX rs5015480 (OR= 1.59, P=0.003), CDKAL1 rs10946398 (OR= 1.43, P=0.008), CDKN2A/B rs10811661 (OR= 1.33, P=0.039), and KCNQ1 rs2237892 (OR=1.46, P=0.009). Conclusions. These data suggest that genetic variations in TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, and KCNQ1 are associated with PTDM in Korea.
KW - Genetic variation
KW - Kidney transplantation
KW - Posttransplantation diabetes mellitus
UR - https://www.scopus.com/pages/publications/70349580509
U2 - 10.1097/TP.0b013e3181b29c41
DO - 10.1097/TP.0b013e3181b29c41
M3 - Article
C2 - 19741467
AN - SCOPUS:70349580509
SN - 0041-1337
VL - 88
SP - 693
EP - 698
JO - Transplantation
JF - Transplantation
IS - 5
ER -
