Association of ambient air pollution with depressive and anxiety symptoms in pregnant women: A prospective cohort study

Dirga Kumar Lamichhane; Dal Young Jung; Yee Jin Shin; Kyung Sook Lee; So Yeon Lee; Kangmo Ahn; Kyung Won Kim; Youn Ho Shin; Dong In Suh; Soo Jong Hong; Hwan Cheol Kim

doi:10.1016/j.ijheh.2021.113823

Association of ambient air pollution with depressive and anxiety symptoms in pregnant women: A prospective cohort study

Dirga Kumar Lamichhane
, Dal Young Jung
, Yee Jin Shin
, Kyung Sook Lee
, So Yeon Lee
, Kangmo Ahn
, Kyung Won Kim
, Youn Ho Shin
, Dong In Suh
, Soo Jong Hong
, Hwan Cheol Kim

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Background: Air pollution is associated with depressive and anxiety symptoms in the general population. However, this relationship among pregnant women remains largely unknown. Objective: To evaluate the association between pregnancy air pollution exposure and maternal depressive and anxiety symptoms during the third trimester assessed using the Center for Epidemiologic Studies-Depression and State-Trait Anxiety Inventory scales, respectively. Methods: We analyzed 1481 pregnant women from a cohort study in Seoul. Maternal exposure to particulate matter with an aerodynamic diameter <2.5 μm (PM_2.5) and <10 μm (PM₁₀), as well as to nitrogen dioxide (NO₂) and ozone (O₃) for each trimester and the entire pregnancy was assessed at participant's residential address by land use regression models. We estimated the relative risk (RR) and corresponding confidence interval (CI) of the depressive and anxiety symptoms associated with an interquartile range (IQR) increase in PM_2.5, PM₁₀, NO₂, and O₃ using modified Poisson regression. Results: In single-pollutant models, an IQR increase in PM_2.5, PM₁₀, and NO₂ during the second trimester was associated with an increased risk of depressive symptoms (PM_2.5 RR = 1.15, 95% CI: 1.04, 1.27; PM₁₀ RR = 1.13, 95% CI: 1.04, 1.23; NO₂ RR = 1.15, 95% CI: 1.03, 1.29) after adjusting for relevant covariates. Similarly, an IQR increase in O₃ during the third trimester was associated with an increased risk of depressive symptoms (RR = 1.09, 95% CI: 1.01, 1.18), while the IQR increase in O₃ during the first trimester was associated with a decreased risk (RR = 0.89, 95% CI: 0.82, 0.96). Exposure to PM_2.5, PM₁₀, and NO₂ during the second trimester was significantly associated with anxiety symptoms. The associations with PM_2.5 and O₃ in single-and multi-pollutant models were consistent. Conclusions: Our findings indicate that increased levels of particulate matter, NO₂, and O₃ during pregnancy may elevate the risk of depression or anxiety in pregnant women.

Original language	English
Article number	113823
Journal	International Journal of Hygiene and Environmental Health
Volume	237
DOIs	https://doi.org/10.1016/j.ijheh.2021.113823
State	Published - Aug 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Air pollution
Anxiety
Depression
Environment
Pregnancy

Access to Document

10.1016/j.ijheh.2021.113823

Cite this

Lamichhane, D. K., Jung, D. Y., Shin, Y. J., Lee, K. S., Lee, S. Y., Ahn, K., Kim, K. W., Shin, Y. H., Suh, D. I., Hong, S. J., & Kim, H. C. (2021). Association of ambient air pollution with depressive and anxiety symptoms in pregnant women: A prospective cohort study. International Journal of Hygiene and Environmental Health, 237, Article 113823. https://doi.org/10.1016/j.ijheh.2021.113823

@article{0dc64db516734672a60535ba12b0055e,

title = "Association of ambient air pollution with depressive and anxiety symptoms in pregnant women: A prospective cohort study",

abstract = "Background: Air pollution is associated with depressive and anxiety symptoms in the general population. However, this relationship among pregnant women remains largely unknown. Objective: To evaluate the association between pregnancy air pollution exposure and maternal depressive and anxiety symptoms during the third trimester assessed using the Center for Epidemiologic Studies-Depression and State-Trait Anxiety Inventory scales, respectively. Methods: We analyzed 1481 pregnant women from a cohort study in Seoul. Maternal exposure to particulate matter with an aerodynamic diameter <2.5 μm (PM2.5) and <10 μm (PM10), as well as to nitrogen dioxide (NO2) and ozone (O3) for each trimester and the entire pregnancy was assessed at participant's residential address by land use regression models. We estimated the relative risk (RR) and corresponding confidence interval (CI) of the depressive and anxiety symptoms associated with an interquartile range (IQR) increase in PM2.5, PM10, NO2, and O3 using modified Poisson regression. Results: In single-pollutant models, an IQR increase in PM2.5, PM10, and NO2 during the second trimester was associated with an increased risk of depressive symptoms (PM2.5 RR = 1.15, 95\% CI: 1.04, 1.27; PM10 RR = 1.13, 95\% CI: 1.04, 1.23; NO2 RR = 1.15, 95\% CI: 1.03, 1.29) after adjusting for relevant covariates. Similarly, an IQR increase in O3 during the third trimester was associated with an increased risk of depressive symptoms (RR = 1.09, 95\% CI: 1.01, 1.18), while the IQR increase in O3 during the first trimester was associated with a decreased risk (RR = 0.89, 95\% CI: 0.82, 0.96). Exposure to PM2.5, PM10, and NO2 during the second trimester was significantly associated with anxiety symptoms. The associations with PM2.5 and O3 in single-and multi-pollutant models were consistent. Conclusions: Our findings indicate that increased levels of particulate matter, NO2, and O3 during pregnancy may elevate the risk of depression or anxiety in pregnant women.",

keywords = "Air pollution, Anxiety, Depression, Environment, Pregnancy",

author = "Lamichhane, \{Dirga Kumar\} and Jung, \{Dal Young\} and Shin, \{Yee Jin\} and Lee, \{Kyung Sook\} and Lee, \{So Yeon\} and Kangmo Ahn and Kim, \{Kyung Won\} and Shin, \{Youn Ho\} and Suh, \{Dong In\} and Hong, \{Soo Jong\} and Kim, \{Hwan Cheol\}",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = aug,

doi = "10.1016/j.ijheh.2021.113823",

language = "English",

volume = "237",

journal = "International Journal of Hygiene and Environmental Health",

issn = "1438-4639",

publisher = "Elsevier GmbH",

}

TY - JOUR

T1 - Association of ambient air pollution with depressive and anxiety symptoms in pregnant women

T2 - A prospective cohort study

AU - Lamichhane, Dirga Kumar

AU - Jung, Dal Young

AU - Shin, Yee Jin

AU - Lee, Kyung Sook

AU - Lee, So Yeon

AU - Ahn, Kangmo

AU - Kim, Kyung Won

AU - Shin, Youn Ho

AU - Suh, Dong In

AU - Hong, Soo Jong

AU - Kim, Hwan Cheol

PY - 2021/8

Y1 - 2021/8

N2 - Background: Air pollution is associated with depressive and anxiety symptoms in the general population. However, this relationship among pregnant women remains largely unknown. Objective: To evaluate the association between pregnancy air pollution exposure and maternal depressive and anxiety symptoms during the third trimester assessed using the Center for Epidemiologic Studies-Depression and State-Trait Anxiety Inventory scales, respectively. Methods: We analyzed 1481 pregnant women from a cohort study in Seoul. Maternal exposure to particulate matter with an aerodynamic diameter <2.5 μm (PM2.5) and <10 μm (PM10), as well as to nitrogen dioxide (NO2) and ozone (O3) for each trimester and the entire pregnancy was assessed at participant's residential address by land use regression models. We estimated the relative risk (RR) and corresponding confidence interval (CI) of the depressive and anxiety symptoms associated with an interquartile range (IQR) increase in PM2.5, PM10, NO2, and O3 using modified Poisson regression. Results: In single-pollutant models, an IQR increase in PM2.5, PM10, and NO2 during the second trimester was associated with an increased risk of depressive symptoms (PM2.5 RR = 1.15, 95% CI: 1.04, 1.27; PM10 RR = 1.13, 95% CI: 1.04, 1.23; NO2 RR = 1.15, 95% CI: 1.03, 1.29) after adjusting for relevant covariates. Similarly, an IQR increase in O3 during the third trimester was associated with an increased risk of depressive symptoms (RR = 1.09, 95% CI: 1.01, 1.18), while the IQR increase in O3 during the first trimester was associated with a decreased risk (RR = 0.89, 95% CI: 0.82, 0.96). Exposure to PM2.5, PM10, and NO2 during the second trimester was significantly associated with anxiety symptoms. The associations with PM2.5 and O3 in single-and multi-pollutant models were consistent. Conclusions: Our findings indicate that increased levels of particulate matter, NO2, and O3 during pregnancy may elevate the risk of depression or anxiety in pregnant women.

AB - Background: Air pollution is associated with depressive and anxiety symptoms in the general population. However, this relationship among pregnant women remains largely unknown. Objective: To evaluate the association between pregnancy air pollution exposure and maternal depressive and anxiety symptoms during the third trimester assessed using the Center for Epidemiologic Studies-Depression and State-Trait Anxiety Inventory scales, respectively. Methods: We analyzed 1481 pregnant women from a cohort study in Seoul. Maternal exposure to particulate matter with an aerodynamic diameter <2.5 μm (PM2.5) and <10 μm (PM10), as well as to nitrogen dioxide (NO2) and ozone (O3) for each trimester and the entire pregnancy was assessed at participant's residential address by land use regression models. We estimated the relative risk (RR) and corresponding confidence interval (CI) of the depressive and anxiety symptoms associated with an interquartile range (IQR) increase in PM2.5, PM10, NO2, and O3 using modified Poisson regression. Results: In single-pollutant models, an IQR increase in PM2.5, PM10, and NO2 during the second trimester was associated with an increased risk of depressive symptoms (PM2.5 RR = 1.15, 95% CI: 1.04, 1.27; PM10 RR = 1.13, 95% CI: 1.04, 1.23; NO2 RR = 1.15, 95% CI: 1.03, 1.29) after adjusting for relevant covariates. Similarly, an IQR increase in O3 during the third trimester was associated with an increased risk of depressive symptoms (RR = 1.09, 95% CI: 1.01, 1.18), while the IQR increase in O3 during the first trimester was associated with a decreased risk (RR = 0.89, 95% CI: 0.82, 0.96). Exposure to PM2.5, PM10, and NO2 during the second trimester was significantly associated with anxiety symptoms. The associations with PM2.5 and O3 in single-and multi-pollutant models were consistent. Conclusions: Our findings indicate that increased levels of particulate matter, NO2, and O3 during pregnancy may elevate the risk of depression or anxiety in pregnant women.

KW - Air pollution

KW - Anxiety

KW - Depression

KW - Environment

KW - Pregnancy

UR - https://www.scopus.com/pages/publications/85111852131

U2 - 10.1016/j.ijheh.2021.113823

DO - 10.1016/j.ijheh.2021.113823

M3 - Article

C2 - 34364017

AN - SCOPUS:85111852131

SN - 1438-4639

VL - 237

JO - International Journal of Hygiene and Environmental Health

JF - International Journal of Hygiene and Environmental Health

M1 - 113823

ER -

Association of ambient air pollution with depressive and anxiety symptoms in pregnant women: A prospective cohort study

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this