Association between Helicobacter pylori infection and Posner-Schlossman syndrome

Objective: To investigate possible association between Helicobacter pyloriinfection and Posner-Schlossman syndrome.Methods:In a prospective study, 40 subjects with Posner-Schlossman syndrome were examined. As a control group, 73 subjects without Posner-Schlossman syndrome were selected for comparison with the study group. All participants underwent serologic analysis for the presence of H. pyloriinfection by an enzyme-linked immunosorbent assay. Positive rate of serum anti-H. pyloriIgG was compared between Posner-Schlossman syndrome patients and control participants.Results:The rate of positive titre (>15 U/ml) of H. pyloriwas 80.0% in the Posner-Schlossman syndrome group and 56.2% in control group, showing significant difference (Fischers exact, P = 0.014). Multivariate analysis adjusted for various systemic factors revealed that positive titre of anti-H. pyloriIgG was a significant risk factor for Posner-Schlossman syndrome with an odds ratio, (4.84, 95.0% CI: 1.10-21.24, P = 0.037).Conclusions:H. pyloriinfection occurred significantly more often in Posner-Schlossman syndrome patients. This study suggests that exposure to H. pyloriinfection is associated with Posner-Schlossman syndrome in Korea.