Anti-coagulating hydroxyethyl starch blended with hyaluronic acid as a novel post-surgical adhesion barrier

Jung Kyu Park; Junseok Yeom; Sei Kwang Hahn; Eui Jin Hwang; Jang Sik Shin; Il Hwan Cho; Suk Ho Bhang; Byung Soo Kim

doi:10.1007/s13233-010-1103-y

Anti-coagulating hydroxyethyl starch blended with hyaluronic acid as a novel post-surgical adhesion barrier

Jung Kyu Park
, Junseok Yeom
, Sei Kwang Hahn
, Eui Jin Hwang
, Jang Sik Shin
, Il Hwan Cho
, Suk Ho Bhang
, Byung Soo Kim

Pohang University of Science and Technology
Shinpoong Pharmaceutical Co.
Seoul National University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Pharmacological and barrier-based approaches have been exploited for the treatment of post-surgical adhesion. In this study, anti-coagulating hydroxyethyl starch (HES) blended with hyaluronic acid (HA) was assessed as a novel post-surgical adhesion barrier in Sprague-Dawley (SD) rats to take advantage of both approaches. The HES/HA blend solution effectively reduced the adhesion area to 6.5% of the control, which might be due to the inhibited blood coagulation by HES as well as highly effective barrier properties of hygroscopic high molecular weight HA. Histological analysis showed that the HES/HA blend solutions effectively protected the smooth muscle cells and skeletal muscle cells from muscle degeneration by adhesion in the abdominal walls of SD rats.

Original language	English
Pages (from-to)	1076-1080
Number of pages	5
Journal	Macromolecular Research
Volume	18
Issue number	11
DOIs	https://doi.org/10.1007/s13233-010-1103-y
State	Published - Nov 2010
Externally published	Yes

Keywords

Hyaluronic acid
Hydroxyethyl starch
Polymer blend
Post-surgical adhesion barrier

Access to Document

10.1007/s13233-010-1103-y

Cite this

@article{c234250a2b364d4c9b59644110b9aedb,

title = "Anti-coagulating hydroxyethyl starch blended with hyaluronic acid as a novel post-surgical adhesion barrier",

abstract = "Pharmacological and barrier-based approaches have been exploited for the treatment of post-surgical adhesion. In this study, anti-coagulating hydroxyethyl starch (HES) blended with hyaluronic acid (HA) was assessed as a novel post-surgical adhesion barrier in Sprague-Dawley (SD) rats to take advantage of both approaches. The HES/HA blend solution effectively reduced the adhesion area to 6.5\% of the control, which might be due to the inhibited blood coagulation by HES as well as highly effective barrier properties of hygroscopic high molecular weight HA. Histological analysis showed that the HES/HA blend solutions effectively protected the smooth muscle cells and skeletal muscle cells from muscle degeneration by adhesion in the abdominal walls of SD rats.",

keywords = "Hyaluronic acid, Hydroxyethyl starch, Polymer blend, Post-surgical adhesion barrier",

author = "Park, \{Jung Kyu\} and Junseok Yeom and Hahn, \{Sei Kwang\} and Hwang, \{Eui Jin\} and Shin, \{Jang Sik\} and Cho, \{Il Hwan\} and Bhang, \{Suk Ho\} and Kim, \{Byung Soo\}",

year = "2010",

month = nov,

doi = "10.1007/s13233-010-1103-y",

language = "English",

volume = "18",

pages = "1076--1080",

journal = "Macromolecular Research",

issn = "1598-5032",

publisher = "Polymer Society of Korea",

number = "11",

}

TY - JOUR

T1 - Anti-coagulating hydroxyethyl starch blended with hyaluronic acid as a novel post-surgical adhesion barrier

AU - Park, Jung Kyu

AU - Yeom, Junseok

AU - Hahn, Sei Kwang

AU - Hwang, Eui Jin

AU - Shin, Jang Sik

AU - Cho, Il Hwan

AU - Bhang, Suk Ho

AU - Kim, Byung Soo

PY - 2010/11

Y1 - 2010/11

N2 - Pharmacological and barrier-based approaches have been exploited for the treatment of post-surgical adhesion. In this study, anti-coagulating hydroxyethyl starch (HES) blended with hyaluronic acid (HA) was assessed as a novel post-surgical adhesion barrier in Sprague-Dawley (SD) rats to take advantage of both approaches. The HES/HA blend solution effectively reduced the adhesion area to 6.5% of the control, which might be due to the inhibited blood coagulation by HES as well as highly effective barrier properties of hygroscopic high molecular weight HA. Histological analysis showed that the HES/HA blend solutions effectively protected the smooth muscle cells and skeletal muscle cells from muscle degeneration by adhesion in the abdominal walls of SD rats.

AB - Pharmacological and barrier-based approaches have been exploited for the treatment of post-surgical adhesion. In this study, anti-coagulating hydroxyethyl starch (HES) blended with hyaluronic acid (HA) was assessed as a novel post-surgical adhesion barrier in Sprague-Dawley (SD) rats to take advantage of both approaches. The HES/HA blend solution effectively reduced the adhesion area to 6.5% of the control, which might be due to the inhibited blood coagulation by HES as well as highly effective barrier properties of hygroscopic high molecular weight HA. Histological analysis showed that the HES/HA blend solutions effectively protected the smooth muscle cells and skeletal muscle cells from muscle degeneration by adhesion in the abdominal walls of SD rats.

KW - Hyaluronic acid

KW - Hydroxyethyl starch

KW - Polymer blend

KW - Post-surgical adhesion barrier

UR - https://www.scopus.com/pages/publications/79951775591

U2 - 10.1007/s13233-010-1103-y

DO - 10.1007/s13233-010-1103-y

M3 - Article

AN - SCOPUS:79951775591

SN - 1598-5032

VL - 18

SP - 1076

EP - 1080

JO - Macromolecular Research

JF - Macromolecular Research

IS - 11

ER -

Anti-coagulating hydroxyethyl starch blended with hyaluronic acid as a novel post-surgical adhesion barrier

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this