Anamorsin, a novel caspase-3 substrate in neurodegeneration

Nuri Yun; Young Mook Lee; Chiho Kim; Hirohiko Shibayama; Akira Tanimura; Yuri Hamanaka; Yuzuru Kanakura; Il Seon Park; Areum Jo; Joo Ho Shin; Chung Ju; Won Ki Kim; Young J. Oh

doi:10.1074/jbc.M114.552679

Anamorsin, a novel caspase-3 substrate in neurodegeneration

Nuri Yun
, Young Mook Lee
, Chiho Kim
, Hirohiko Shibayama
, Akira Tanimura
, Yuri Hamanaka
, Yuzuru Kanakura
, Il Seon Park
, Areum Jo
, Joo Ho Shin
, Chung Ju
, Won Ki Kim
, Young J. Oh

Yonsei University
The University of Osaka
Chosun University
Sungkyunkwan University
Korea University

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Background: It is crucial to identify caspase-3 substrates and their roles during neurodegeneration. Results: Our approach identified 46 novel substrates. Furthermore, we found that anamorsin was cleaved by caspase-3 and mapped its cleavage site. Conclusion: Anamorsin may play an antiapoptotic role in the central nervous system. Significance: Our findings contribute to understanding the molecular mechanism underlying role for anamorsin in caspase-3- mediated cell death.

Original language	English
Pages (from-to)	22183-22195
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	289
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M114.552679
State	Published - 8 Aug 2014
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1074/jbc.M114.552679

Cite this

@article{dc063ef101a345469ceeced2fedd89a3,

title = "Anamorsin, a novel caspase-3 substrate in neurodegeneration",

abstract = "Background: It is crucial to identify caspase-3 substrates and their roles during neurodegeneration. Results: Our approach identified 46 novel substrates. Furthermore, we found that anamorsin was cleaved by caspase-3 and mapped its cleavage site. Conclusion: Anamorsin may play an antiapoptotic role in the central nervous system. Significance: Our findings contribute to understanding the molecular mechanism underlying role for anamorsin in caspase-3- mediated cell death.",

author = "Nuri Yun and Lee, \{Young Mook\} and Chiho Kim and Hirohiko Shibayama and Akira Tanimura and Yuri Hamanaka and Yuzuru Kanakura and Park, \{Il Seon\} and Areum Jo and Shin, \{Joo Ho\} and Chung Ju and Kim, \{Won Ki\} and Oh, \{Young J.\}",

year = "2014",

month = aug,

day = "8",

doi = "10.1074/jbc.M114.552679",

language = "English",

volume = "289",

pages = "22183--22195",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

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}

TY - JOUR

T1 - Anamorsin, a novel caspase-3 substrate in neurodegeneration

AU - Yun, Nuri

AU - Lee, Young Mook

AU - Kim, Chiho

AU - Shibayama, Hirohiko

AU - Tanimura, Akira

AU - Hamanaka, Yuri

AU - Kanakura, Yuzuru

AU - Park, Il Seon

AU - Jo, Areum

AU - Shin, Joo Ho

AU - Ju, Chung

AU - Kim, Won Ki

AU - Oh, Young J.

PY - 2014/8/8

Y1 - 2014/8/8

N2 - Background: It is crucial to identify caspase-3 substrates and their roles during neurodegeneration. Results: Our approach identified 46 novel substrates. Furthermore, we found that anamorsin was cleaved by caspase-3 and mapped its cleavage site. Conclusion: Anamorsin may play an antiapoptotic role in the central nervous system. Significance: Our findings contribute to understanding the molecular mechanism underlying role for anamorsin in caspase-3- mediated cell death.

AB - Background: It is crucial to identify caspase-3 substrates and their roles during neurodegeneration. Results: Our approach identified 46 novel substrates. Furthermore, we found that anamorsin was cleaved by caspase-3 and mapped its cleavage site. Conclusion: Anamorsin may play an antiapoptotic role in the central nervous system. Significance: Our findings contribute to understanding the molecular mechanism underlying role for anamorsin in caspase-3- mediated cell death.

UR - https://www.scopus.com/pages/publications/84905851425

U2 - 10.1074/jbc.M114.552679

DO - 10.1074/jbc.M114.552679

M3 - Article

C2 - 24973211

AN - SCOPUS:84905851425

SN - 0021-9258

VL - 289

SP - 22183

EP - 22195

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 32

ER -

Anamorsin, a novel caspase-3 substrate in neurodegeneration

Abstract

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