An on-demand pH-sensitive nanocluster for cancer treatment by combining photothermal therapy and chemotherapy

Taehoon Sim; Chaemin Lim; Ngoc Ha Hoang; Yuseon Shin; Jae Chang Kim; June Yong Park; Jaewon Her; Eun Seong Lee; Yu Seok Youn; Kyung Taek Oh

doi:10.3390/pharmaceutics12090839

An on-demand pH-sensitive nanocluster for cancer treatment by combining photothermal therapy and chemotherapy

Taehoon Sim
, Chaemin Lim
, Ngoc Ha Hoang
, Yuseon Shin
, Jae Chang Kim
, June Yong Park
, Jaewon Her
, Eun Seong Lee
, Yu Seok Youn
, Kyung Taek Oh

Department of Pharmacy

Chung-Ang University
The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Combination therapy is considered to be a promising strategy for improving the therapeutic efficiency of cancer treatment. In this study, an on-demand pH-sensitive nanocluster (NC) system was prepared by the encapsulation of gold nanorods (AuNR) and doxorubicin (DOX) by a pH-sensitive polymer, poly(aspartic acid-graft-imidazole)-PEG, to enhance the therapeutic effect of chemotherapy and photothermal therapy. At pH 6.5, the NC systems formed aggregated structures and released higher drug amounts while sustaining a stable nano-assembly, structured with less systemic toxicity at pH 7.4. The NC could also increase antitumor efficacy as a result of improved accumulation and release of DOX from the NC system at pH_ex and pH_en with locally applied near-infrared light. Therefore, an NC system would be a potent strategy for on-demand combination treatment to target tumors with less systemic toxicity and an improved therapeutic effect.

Original language	English
Article number	839
Pages (from-to)	1-14
Number of pages	14
Journal	Pharmaceutics
Volume	12
Issue number	9
DOIs	https://doi.org/10.3390/pharmaceutics12090839
State	Published - Sep 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
Chemotherapy
Controlled release
Gold nanorod
Nanocluster
PH sensitive polymer
Photothermal therapy

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10.3390/pharmaceutics12090839

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title = "An on-demand pH-sensitive nanocluster for cancer treatment by combining photothermal therapy and chemotherapy",

abstract = "Combination therapy is considered to be a promising strategy for improving the therapeutic efficiency of cancer treatment. In this study, an on-demand pH-sensitive nanocluster (NC) system was prepared by the encapsulation of gold nanorods (AuNR) and doxorubicin (DOX) by a pH-sensitive polymer, poly(aspartic acid-graft-imidazole)-PEG, to enhance the therapeutic effect of chemotherapy and photothermal therapy. At pH 6.5, the NC systems formed aggregated structures and released higher drug amounts while sustaining a stable nano-assembly, structured with less systemic toxicity at pH 7.4. The NC could also increase antitumor efficacy as a result of improved accumulation and release of DOX from the NC system at pHex and pHen with locally applied near-infrared light. Therefore, an NC system would be a potent strategy for on-demand combination treatment to target tumors with less systemic toxicity and an improved therapeutic effect.",

keywords = "Cancer, Chemotherapy, Controlled release, Gold nanorod, Nanocluster, PH sensitive polymer, Photothermal therapy",

author = "Taehoon Sim and Chaemin Lim and Hoang, \{Ngoc Ha\} and Yuseon Shin and Kim, \{Jae Chang\} and Park, \{June Yong\} and Jaewon Her and Lee, \{Eun Seong\} and Youn, \{Yu Seok\} and Oh, \{Kyung Taek\}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = sep,

doi = "10.3390/pharmaceutics12090839",

language = "English",

volume = "12",

pages = "1--14",

journal = "Pharmaceutics",

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T1 - An on-demand pH-sensitive nanocluster for cancer treatment by combining photothermal therapy and chemotherapy

AU - Sim, Taehoon

AU - Lim, Chaemin

AU - Hoang, Ngoc Ha

AU - Shin, Yuseon

AU - Kim, Jae Chang

AU - Park, June Yong

AU - Her, Jaewon

AU - Lee, Eun Seong

AU - Youn, Yu Seok

AU - Oh, Kyung Taek

PY - 2020/9

Y1 - 2020/9

N2 - Combination therapy is considered to be a promising strategy for improving the therapeutic efficiency of cancer treatment. In this study, an on-demand pH-sensitive nanocluster (NC) system was prepared by the encapsulation of gold nanorods (AuNR) and doxorubicin (DOX) by a pH-sensitive polymer, poly(aspartic acid-graft-imidazole)-PEG, to enhance the therapeutic effect of chemotherapy and photothermal therapy. At pH 6.5, the NC systems formed aggregated structures and released higher drug amounts while sustaining a stable nano-assembly, structured with less systemic toxicity at pH 7.4. The NC could also increase antitumor efficacy as a result of improved accumulation and release of DOX from the NC system at pHex and pHen with locally applied near-infrared light. Therefore, an NC system would be a potent strategy for on-demand combination treatment to target tumors with less systemic toxicity and an improved therapeutic effect.

AB - Combination therapy is considered to be a promising strategy for improving the therapeutic efficiency of cancer treatment. In this study, an on-demand pH-sensitive nanocluster (NC) system was prepared by the encapsulation of gold nanorods (AuNR) and doxorubicin (DOX) by a pH-sensitive polymer, poly(aspartic acid-graft-imidazole)-PEG, to enhance the therapeutic effect of chemotherapy and photothermal therapy. At pH 6.5, the NC systems formed aggregated structures and released higher drug amounts while sustaining a stable nano-assembly, structured with less systemic toxicity at pH 7.4. The NC could also increase antitumor efficacy as a result of improved accumulation and release of DOX from the NC system at pHex and pHen with locally applied near-infrared light. Therefore, an NC system would be a potent strategy for on-demand combination treatment to target tumors with less systemic toxicity and an improved therapeutic effect.

KW - Cancer

KW - Chemotherapy

KW - Controlled release

KW - Gold nanorod

KW - Nanocluster

KW - PH sensitive polymer

KW - Photothermal therapy

UR - https://www.scopus.com/pages/publications/85093880876

U2 - 10.3390/pharmaceutics12090839

DO - 10.3390/pharmaceutics12090839

M3 - Article

AN - SCOPUS:85093880876

SN - 1999-4923

VL - 12

SP - 1

EP - 14

JO - Pharmaceutics

JF - Pharmaceutics

IS - 9

M1 - 839

ER -

An on-demand pH-sensitive nanocluster for cancer treatment by combining photothermal therapy and chemotherapy

Abstract

UN SDGs

Keywords

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