An on-demand pH-sensitive nanocluster for cancer treatment by combining photothermal therapy and chemotherapy

Taehoon Sim; Chaemin Lim; Ngoc Ha Hoang; Yuseon Shin; Jae Chang Kim; June Yong Park; Jaewon Her; Eun Seong Lee; Yu Seok Youn; Kyung Taek Oh

doi:10.3390/pharmaceutics12090839

An on-demand pH-sensitive nanocluster for cancer treatment by combining photothermal therapy and chemotherapy

Taehoon Sim, Chaemin Lim, Ngoc Ha Hoang, Yuseon Shin, Jae Chang Kim, June Yong Park, Jaewon Her, Eun Seong Lee, Yu Seok Youn, Kyung Taek Oh

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Combination therapy is considered to be a promising strategy for improving the therapeutic efficiency of cancer treatment. In this study, an on-demand pH-sensitive nanocluster (NC) system was prepared by the encapsulation of gold nanorods (AuNR) and doxorubicin (DOX) by a pH-sensitive polymer, poly(aspartic acid-graft-imidazole)-PEG, to enhance the therapeutic effect of chemotherapy and photothermal therapy. At pH 6.5, the NC systems formed aggregated structures and released higher drug amounts while sustaining a stable nano-assembly, structured with less systemic toxicity at pH 7.4. The NC could also increase antitumor efficacy as a result of improved accumulation and release of DOX from the NC system at pH_ex and pH_en with locally applied near-infrared light. Therefore, an NC system would be a potent strategy for on-demand combination treatment to target tumors with less systemic toxicity and an improved therapeutic effect.

Original language	English
Article number	839
Pages (from-to)	1-14
Number of pages	14
Journal	Pharmaceutics
Volume	12
Issue number	9
DOIs	https://doi.org/10.3390/pharmaceutics12090839
State	Published - Sep 2020

Keywords

Cancer
Chemotherapy
Controlled release
Gold nanorod
Nanocluster
PH sensitive polymer
Photothermal therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/pharmaceutics12090839

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@article{16f2955a53f54ce5883d6c1407e10956,

title = "An on-demand pH-sensitive nanocluster for cancer treatment by combining photothermal therapy and chemotherapy",

abstract = "Combination therapy is considered to be a promising strategy for improving the therapeutic efficiency of cancer treatment. In this study, an on-demand pH-sensitive nanocluster (NC) system was prepared by the encapsulation of gold nanorods (AuNR) and doxorubicin (DOX) by a pH-sensitive polymer, poly(aspartic acid-graft-imidazole)-PEG, to enhance the therapeutic effect of chemotherapy and photothermal therapy. At pH 6.5, the NC systems formed aggregated structures and released higher drug amounts while sustaining a stable nano-assembly, structured with less systemic toxicity at pH 7.4. The NC could also increase antitumor efficacy as a result of improved accumulation and release of DOX from the NC system at pHex and pHen with locally applied near-infrared light. Therefore, an NC system would be a potent strategy for on-demand combination treatment to target tumors with less systemic toxicity and an improved therapeutic effect.",

keywords = "Cancer, Chemotherapy, Controlled release, Gold nanorod, Nanocluster, PH sensitive polymer, Photothermal therapy",

author = "Taehoon Sim and Chaemin Lim and Hoang, \{Ngoc Ha\} and Yuseon Shin and Kim, \{Jae Chang\} and Park, \{June Yong\} and Jaewon Her and Lee, \{Eun Seong\} and Youn, \{Yu Seok\} and Oh, \{Kyung Taek\}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = sep,

doi = "10.3390/pharmaceutics12090839",

language = "English",

volume = "12",

pages = "1--14",

journal = "Pharmaceutics",

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TY - JOUR

T1 - An on-demand pH-sensitive nanocluster for cancer treatment by combining photothermal therapy and chemotherapy

AU - Sim, Taehoon

AU - Lim, Chaemin

AU - Hoang, Ngoc Ha

AU - Shin, Yuseon

AU - Kim, Jae Chang

AU - Park, June Yong

AU - Her, Jaewon

AU - Lee, Eun Seong

AU - Youn, Yu Seok

AU - Oh, Kyung Taek

PY - 2020/9

Y1 - 2020/9

N2 - Combination therapy is considered to be a promising strategy for improving the therapeutic efficiency of cancer treatment. In this study, an on-demand pH-sensitive nanocluster (NC) system was prepared by the encapsulation of gold nanorods (AuNR) and doxorubicin (DOX) by a pH-sensitive polymer, poly(aspartic acid-graft-imidazole)-PEG, to enhance the therapeutic effect of chemotherapy and photothermal therapy. At pH 6.5, the NC systems formed aggregated structures and released higher drug amounts while sustaining a stable nano-assembly, structured with less systemic toxicity at pH 7.4. The NC could also increase antitumor efficacy as a result of improved accumulation and release of DOX from the NC system at pHex and pHen with locally applied near-infrared light. Therefore, an NC system would be a potent strategy for on-demand combination treatment to target tumors with less systemic toxicity and an improved therapeutic effect.

AB - Combination therapy is considered to be a promising strategy for improving the therapeutic efficiency of cancer treatment. In this study, an on-demand pH-sensitive nanocluster (NC) system was prepared by the encapsulation of gold nanorods (AuNR) and doxorubicin (DOX) by a pH-sensitive polymer, poly(aspartic acid-graft-imidazole)-PEG, to enhance the therapeutic effect of chemotherapy and photothermal therapy. At pH 6.5, the NC systems formed aggregated structures and released higher drug amounts while sustaining a stable nano-assembly, structured with less systemic toxicity at pH 7.4. The NC could also increase antitumor efficacy as a result of improved accumulation and release of DOX from the NC system at pHex and pHen with locally applied near-infrared light. Therefore, an NC system would be a potent strategy for on-demand combination treatment to target tumors with less systemic toxicity and an improved therapeutic effect.

KW - Cancer

KW - Chemotherapy

KW - Controlled release

KW - Gold nanorod

KW - Nanocluster

KW - PH sensitive polymer

KW - Photothermal therapy

UR - https://www.scopus.com/pages/publications/85093880876

U2 - 10.3390/pharmaceutics12090839

DO - 10.3390/pharmaceutics12090839

M3 - Article

AN - SCOPUS:85093880876

SN - 1999-4923

VL - 12

SP - 1

EP - 14

JO - Pharmaceutics

JF - Pharmaceutics

IS - 9

M1 - 839

ER -

An on-demand pH-sensitive nanocluster for cancer treatment by combining photothermal therapy and chemotherapy

Abstract

Keywords

UN SDGs

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