Alzheimer peptides perturb lipid-regulating enzymes

Mark P. Mattson; Roy G. Cutler; Dong Gyu Jo

doi:10.1038/ncb1105-1045

Alzheimer peptides perturb lipid-regulating enzymes

Mark P. Mattson
, Roy G. Cutler
, Dong Gyu Jo

National Institutes of Health

Research output: Contribution to journal › Comment/debate

31 Scopus citations

Abstract

An increase in the size of the amyloid β-peptide (Aβ versus Aβ40) may be a key factor in the pathogenesis of Alzheimer's disease. By altering the activities of enzymes involved in the metabolism of cholesterol and sphingomyelin, an increase in the Aβ42:Aβ40 ratio may cause dysfunction and death of neurons.

Original language	English
Pages (from-to)	1045-1047
Number of pages	3
Journal	Nature Cell Biology
Volume	7
Issue number	11
DOIs	https://doi.org/10.1038/ncb1105-1045
State	Published - Nov 2005
Externally published	Yes

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10.1038/ncb1105-1045

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title = "Alzheimer peptides perturb lipid-regulating enzymes",

abstract = "An increase in the size of the amyloid β-peptide (Aβ versus Aβ40) may be a key factor in the pathogenesis of Alzheimer's disease. By altering the activities of enzymes involved in the metabolism of cholesterol and sphingomyelin, an increase in the Aβ42:Aβ40 ratio may cause dysfunction and death of neurons.",

author = "Mattson, \{Mark P.\} and Cutler, \{Roy G.\} and Jo, \{Dong Gyu\}",

year = "2005",

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AU - Mattson, Mark P.

AU - Cutler, Roy G.

AU - Jo, Dong Gyu

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N2 - An increase in the size of the amyloid β-peptide (Aβ versus Aβ40) may be a key factor in the pathogenesis of Alzheimer's disease. By altering the activities of enzymes involved in the metabolism of cholesterol and sphingomyelin, an increase in the Aβ42:Aβ40 ratio may cause dysfunction and death of neurons.

AB - An increase in the size of the amyloid β-peptide (Aβ versus Aβ40) may be a key factor in the pathogenesis of Alzheimer's disease. By altering the activities of enzymes involved in the metabolism of cholesterol and sphingomyelin, an increase in the Aβ42:Aβ40 ratio may cause dysfunction and death of neurons.

UR - https://www.scopus.com/pages/publications/30444449575

U2 - 10.1038/ncb1105-1045

DO - 10.1038/ncb1105-1045

M3 - Comment/debate

C2 - 16385731

AN - SCOPUS:30444449575

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VL - 7

SP - 1045

EP - 1047

JO - Nature Cell Biology

JF - Nature Cell Biology

IS - 11

ER -

Alzheimer peptides perturb lipid-regulating enzymes

Abstract

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