Alkaloids of NIRAM, natural dye from Polygonum tinctorium, and their anti-inflammatory activities

Dong Hyun Kim; Chung Sub Kim; Lalita Subedi; Sun Yeou Kim; Kang Ro Lee

doi:10.1016/j.tetlet.2019.151130

Alkaloids of NIRAM, natural dye from Polygonum tinctorium, and their anti-inflammatory activities

Dong Hyun Kim
, Chung Sub Kim
, Lalita Subedi
, Sun Yeou Kim
, Kang Ro Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Phytochemical investigation of EtOH extract of NIRAM, natural dye from Polygonum tinctorium, resulted in the purification of nine alkaloid compounds (1–9) including four new compounds (1–4). Structures of these new compounds were elucidated by 1D and 2D NMR (¹H and ¹³C NMR, ¹H–¹H COSY, ¹H–¹³C HSQC, ¹H–¹³C HMBC), IR, UV, HR-ESI-MS, and ECD spectra. Isolated compounds (1–9) were tested for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells. Compounds 1–3, 5, and 7 showed potent NO production inhibitory activities, with IC₅₀ values of 3.88–22.87 μM.

Original language	English
Article number	151130
Journal	Tetrahedron Letters
Volume	60
Issue number	41
DOIs	https://doi.org/10.1016/j.tetlet.2019.151130
State	Published - 10 Oct 2019

Keywords

Anti-Inflammatory activities
Indole alkaloids
NIRAM
Polygonum tinctorium

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10.1016/j.tetlet.2019.151130

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title = "Alkaloids of NIRAM, natural dye from Polygonum tinctorium, and their anti-inflammatory activities",

abstract = "Phytochemical investigation of EtOH extract of NIRAM, natural dye from Polygonum tinctorium, resulted in the purification of nine alkaloid compounds (1–9) including four new compounds (1–4). Structures of these new compounds were elucidated by 1D and 2D NMR (1H and 13C NMR, 1H–1H COSY, 1H–13C HSQC, 1H–13C HMBC), IR, UV, HR-ESI-MS, and ECD spectra. Isolated compounds (1–9) were tested for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells. Compounds 1–3, 5, and 7 showed potent NO production inhibitory activities, with IC50 values of 3.88–22.87 μM.",

keywords = "Anti-Inflammatory activities, Indole alkaloids, NIRAM, Polygonum tinctorium",

author = "Kim, \{Dong Hyun\} and Kim, \{Chung Sub\} and Lalita Subedi and Kim, \{Sun Yeou\} and Lee, \{Kang Ro\}",

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doi = "10.1016/j.tetlet.2019.151130",

language = "English",

volume = "60",

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T1 - Alkaloids of NIRAM, natural dye from Polygonum tinctorium, and their anti-inflammatory activities

AU - Kim, Dong Hyun

AU - Kim, Chung Sub

AU - Subedi, Lalita

AU - Kim, Sun Yeou

AU - Lee, Kang Ro

PY - 2019/10/10

Y1 - 2019/10/10

N2 - Phytochemical investigation of EtOH extract of NIRAM, natural dye from Polygonum tinctorium, resulted in the purification of nine alkaloid compounds (1–9) including four new compounds (1–4). Structures of these new compounds were elucidated by 1D and 2D NMR (1H and 13C NMR, 1H–1H COSY, 1H–13C HSQC, 1H–13C HMBC), IR, UV, HR-ESI-MS, and ECD spectra. Isolated compounds (1–9) were tested for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells. Compounds 1–3, 5, and 7 showed potent NO production inhibitory activities, with IC50 values of 3.88–22.87 μM.

AB - Phytochemical investigation of EtOH extract of NIRAM, natural dye from Polygonum tinctorium, resulted in the purification of nine alkaloid compounds (1–9) including four new compounds (1–4). Structures of these new compounds were elucidated by 1D and 2D NMR (1H and 13C NMR, 1H–1H COSY, 1H–13C HSQC, 1H–13C HMBC), IR, UV, HR-ESI-MS, and ECD spectra. Isolated compounds (1–9) were tested for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells. Compounds 1–3, 5, and 7 showed potent NO production inhibitory activities, with IC50 values of 3.88–22.87 μM.

KW - Anti-Inflammatory activities

KW - Indole alkaloids

KW - NIRAM

KW - Polygonum tinctorium

UR - https://www.scopus.com/pages/publications/85072085301

U2 - 10.1016/j.tetlet.2019.151130

DO - 10.1016/j.tetlet.2019.151130

M3 - Article

AN - SCOPUS:85072085301

SN - 0040-4039

VL - 60

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 41

M1 - 151130

ER -

Alkaloids of NIRAM, natural dye from Polygonum tinctorium, and their anti-inflammatory activities

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Keywords

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