Age-related upregulation of insulin-like growth factor receptor type I in rat cerebellum

Yoon Hee Chung; Chung Min Shin; Kyeung Min Joo; Myeung Ju Kim; Choong Ik Cha

doi:10.1016/S0304-3940(02)00740-1

Age-related upregulation of insulin-like growth factor receptor type I in rat cerebellum

Yoon Hee Chung
, Chung Min Shin
, Kyeung Min Joo
, Myeung Ju Kim
, Choong Ik Cha

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We investigated age-related changes in insulin-like growth factor-I (IGF-I) receptor localization in the cerebellum using immunohistochemical staining. In adult rats, no immunoreactivity for IGF-I receptor was found in any layers of cerebellar cortex. In contrast, IGF-I receptor immunoreactivity was found in the cerebellar cortex of aged rats. The most prominent labeling was localized in the Purkinje cell layers and molecular layers. The cerebellar output neurons showed little immunoreactivity for IGF-I receptor in the nucleus medialis, interpositus and lateralis of adult rats. In aged cerebellar nuclei, IGF-I receptor immunoreactivity was observed in the surrounding neuropil. The first demonstration of upregulation of IGF-I receptor in aged rat cerebellum suggests that IGF-I may promote the survival of a degenerated population of the Purkinje neurons by increases in IGF-I receptor expression during aging.

Original language	English
Pages (from-to)	65-68
Number of pages	4
Journal	Neuroscience Letters
Volume	330
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(02)00740-1
State	Published - 13 Sep 2002
Externally published	Yes

Keywords

Aging
Cerebellum
Immunohistochemistry
Insulin-like growth factor-I
Insulin-like growth factor-I receptor
Rat

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10.1016/S0304-3940(02)00740-1

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title = "Age-related upregulation of insulin-like growth factor receptor type I in rat cerebellum",

abstract = "We investigated age-related changes in insulin-like growth factor-I (IGF-I) receptor localization in the cerebellum using immunohistochemical staining. In adult rats, no immunoreactivity for IGF-I receptor was found in any layers of cerebellar cortex. In contrast, IGF-I receptor immunoreactivity was found in the cerebellar cortex of aged rats. The most prominent labeling was localized in the Purkinje cell layers and molecular layers. The cerebellar output neurons showed little immunoreactivity for IGF-I receptor in the nucleus medialis, interpositus and lateralis of adult rats. In aged cerebellar nuclei, IGF-I receptor immunoreactivity was observed in the surrounding neuropil. The first demonstration of upregulation of IGF-I receptor in aged rat cerebellum suggests that IGF-I may promote the survival of a degenerated population of the Purkinje neurons by increases in IGF-I receptor expression during aging.",

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doi = "10.1016/S0304-3940(02)00740-1",

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T1 - Age-related upregulation of insulin-like growth factor receptor type I in rat cerebellum

AU - Chung, Yoon Hee

AU - Shin, Chung Min

AU - Joo, Kyeung Min

AU - Kim, Myeung Ju

AU - Cha, Choong Ik

PY - 2002/9/13

Y1 - 2002/9/13

N2 - We investigated age-related changes in insulin-like growth factor-I (IGF-I) receptor localization in the cerebellum using immunohistochemical staining. In adult rats, no immunoreactivity for IGF-I receptor was found in any layers of cerebellar cortex. In contrast, IGF-I receptor immunoreactivity was found in the cerebellar cortex of aged rats. The most prominent labeling was localized in the Purkinje cell layers and molecular layers. The cerebellar output neurons showed little immunoreactivity for IGF-I receptor in the nucleus medialis, interpositus and lateralis of adult rats. In aged cerebellar nuclei, IGF-I receptor immunoreactivity was observed in the surrounding neuropil. The first demonstration of upregulation of IGF-I receptor in aged rat cerebellum suggests that IGF-I may promote the survival of a degenerated population of the Purkinje neurons by increases in IGF-I receptor expression during aging.

AB - We investigated age-related changes in insulin-like growth factor-I (IGF-I) receptor localization in the cerebellum using immunohistochemical staining. In adult rats, no immunoreactivity for IGF-I receptor was found in any layers of cerebellar cortex. In contrast, IGF-I receptor immunoreactivity was found in the cerebellar cortex of aged rats. The most prominent labeling was localized in the Purkinje cell layers and molecular layers. The cerebellar output neurons showed little immunoreactivity for IGF-I receptor in the nucleus medialis, interpositus and lateralis of adult rats. In aged cerebellar nuclei, IGF-I receptor immunoreactivity was observed in the surrounding neuropil. The first demonstration of upregulation of IGF-I receptor in aged rat cerebellum suggests that IGF-I may promote the survival of a degenerated population of the Purkinje neurons by increases in IGF-I receptor expression during aging.

KW - Aging

KW - Cerebellum

KW - Immunohistochemistry

KW - Insulin-like growth factor-I

KW - Insulin-like growth factor-I receptor

KW - Rat

UR - https://www.scopus.com/pages/publications/0037072534

U2 - 10.1016/S0304-3940(02)00740-1

DO - 10.1016/S0304-3940(02)00740-1

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AN - SCOPUS:0037072534

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SP - 65

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Age-related upregulation of insulin-like growth factor receptor type I in rat cerebellum

Abstract

Keywords

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