Advanced smart-photosensitizers for more effective cancer treatment

Wooram Park; Soojeong Cho; Jieun Han; Heejun Shin; Kun Na; Byeongdu Lee; Dong Hyun Kim

doi:10.1039/c7bm00872d

Advanced smart-photosensitizers for more effective cancer treatment

Wooram Park, Soojeong Cho, Jieun Han, Heejun Shin, Kun Na, Byeongdu Lee, Dong Hyun Kim

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

Photodynamic therapy (PDT) based upon the use of light and photosensitizers (PSs) has been used as a novel treatment approach for a variety of tumors. It, however, has several major limitations in the clinic: poor water solubility, long-term phototoxicity, low tumor targeting efficacy, and limited light penetration. With advances in nanotechnology, materials science, and clinical interventional imaging procedures, various smart-PSs have been developed for improving their cancer-therapeutic efficacy while reducing the adverse effects. Here, we briefly review state-of-the-art smart-PSs and discuss the future directions of PDT technology.

Original language	English
Pages (from-to)	79-90
Number of pages	12
Journal	Biomaterials Science
Volume	6
Issue number	1
DOIs	https://doi.org/10.1039/c7bm00872d
State	Published - Jan 2018
Externally published	Yes

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10.1039/c7bm00872d

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title = "Advanced smart-photosensitizers for more effective cancer treatment",

abstract = "Photodynamic therapy (PDT) based upon the use of light and photosensitizers (PSs) has been used as a novel treatment approach for a variety of tumors. It, however, has several major limitations in the clinic: poor water solubility, long-term phototoxicity, low tumor targeting efficacy, and limited light penetration. With advances in nanotechnology, materials science, and clinical interventional imaging procedures, various smart-PSs have been developed for improving their cancer-therapeutic efficacy while reducing the adverse effects. Here, we briefly review state-of-the-art smart-PSs and discuss the future directions of PDT technology.",

author = "Wooram Park and Soojeong Cho and Jieun Han and Heejun Shin and Kun Na and Byeongdu Lee and Kim, \{Dong Hyun\}",

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year = "2018",

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doi = "10.1039/c7bm00872d",

language = "English",

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pages = "79--90",

journal = "Biomaterials Science",

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T1 - Advanced smart-photosensitizers for more effective cancer treatment

AU - Park, Wooram

AU - Cho, Soojeong

AU - Han, Jieun

AU - Shin, Heejun

AU - Na, Kun

AU - Lee, Byeongdu

AU - Kim, Dong Hyun

PY - 2018/1

Y1 - 2018/1

N2 - Photodynamic therapy (PDT) based upon the use of light and photosensitizers (PSs) has been used as a novel treatment approach for a variety of tumors. It, however, has several major limitations in the clinic: poor water solubility, long-term phototoxicity, low tumor targeting efficacy, and limited light penetration. With advances in nanotechnology, materials science, and clinical interventional imaging procedures, various smart-PSs have been developed for improving their cancer-therapeutic efficacy while reducing the adverse effects. Here, we briefly review state-of-the-art smart-PSs and discuss the future directions of PDT technology.

AB - Photodynamic therapy (PDT) based upon the use of light and photosensitizers (PSs) has been used as a novel treatment approach for a variety of tumors. It, however, has several major limitations in the clinic: poor water solubility, long-term phototoxicity, low tumor targeting efficacy, and limited light penetration. With advances in nanotechnology, materials science, and clinical interventional imaging procedures, various smart-PSs have been developed for improving their cancer-therapeutic efficacy while reducing the adverse effects. Here, we briefly review state-of-the-art smart-PSs and discuss the future directions of PDT technology.

UR - https://www.scopus.com/pages/publications/85038969944

U2 - 10.1039/c7bm00872d

DO - 10.1039/c7bm00872d

M3 - Article

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AN - SCOPUS:85038969944

SN - 2047-4830

VL - 6

SP - 79

EP - 90

JO - Biomaterials Science

JF - Biomaterials Science

IS - 1

ER -

Advanced smart-photosensitizers for more effective cancer treatment

Abstract

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