A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: In vitro evaluation

Nam Muk Oh; Kyung Taek Oh; Hye Jung Baik; Bo Reum Lee; A. Hyeong Lee; Yu Seok Youn; Eun Seong Lee

doi:10.1016/j.colsurfb.2010.02.023

A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: In vitro evaluation

Nam Muk Oh
, Kyung Taek Oh
, Hye Jung Baik
, Bo Reum Lee
, A. Hyeong Lee
, Yu Seok Youn
, Eun Seong Lee

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

In this study, a novel pH-responsive nanogel composed of glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups (denoted as GCS-g-DEAP hereafter) was fabricated. The GCS-g-DEAP was designed to have a self-assembled arrangement consisting of hydrophilic block (GCS) and hydrophobic block (DEAP) at physiological pH. As the pH decreased to tumor extracellular pH (pH_e), the nanogel was destabilized due to the protonation of DEAP. The pH-responsive property of the nanogel at tumor extracellular pH (pH_e) was characterized in drug-release kinetic studies. The release of doxorubicin (DOX) from DOX-loaded nanogels was significantly accelerated at lower pH values, which allowed for increased DOX uptake by non-small lung carcinoma A546 cells under a slightly acidic pH condition, as in tumor pH_e.

Original language	English
Pages (from-to)	120-126
Number of pages	7
Journal	Colloids and Surfaces B: Biointerfaces
Volume	78
Issue number	1
DOIs	https://doi.org/10.1016/j.colsurfb.2010.02.023
State	Published - 2010
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

3-Diethylaminopropyl
Glycol chitosan
PH-responsive nanogel
Tumor extracellular pH

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10.1016/j.colsurfb.2010.02.023

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title = "A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: In vitro evaluation",

abstract = "In this study, a novel pH-responsive nanogel composed of glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups (denoted as GCS-g-DEAP hereafter) was fabricated. The GCS-g-DEAP was designed to have a self-assembled arrangement consisting of hydrophilic block (GCS) and hydrophobic block (DEAP) at physiological pH. As the pH decreased to tumor extracellular pH (pHe), the nanogel was destabilized due to the protonation of DEAP. The pH-responsive property of the nanogel at tumor extracellular pH (pHe) was characterized in drug-release kinetic studies. The release of doxorubicin (DOX) from DOX-loaded nanogels was significantly accelerated at lower pH values, which allowed for increased DOX uptake by non-small lung carcinoma A546 cells under a slightly acidic pH condition, as in tumor pHe.",

keywords = "3-Diethylaminopropyl, Glycol chitosan, PH-responsive nanogel, Tumor extracellular pH",

author = "Oh, \{Nam Muk\} and Oh, \{Kyung Taek\} and Baik, \{Hye Jung\} and Lee, \{Bo Reum\} and Lee, \{A. Hyeong\} and Youn, \{Yu Seok\} and Lee, \{Eun Seong\}",

year = "2010",

doi = "10.1016/j.colsurfb.2010.02.023",

language = "English",

volume = "78",

pages = "120--126",

journal = "Colloids and Surfaces B: Biointerfaces",

issn = "0927-7765",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting

T2 - In vitro evaluation

AU - Oh, Nam Muk

AU - Oh, Kyung Taek

AU - Baik, Hye Jung

AU - Lee, Bo Reum

AU - Lee, A. Hyeong

AU - Youn, Yu Seok

AU - Lee, Eun Seong

PY - 2010

Y1 - 2010

N2 - In this study, a novel pH-responsive nanogel composed of glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups (denoted as GCS-g-DEAP hereafter) was fabricated. The GCS-g-DEAP was designed to have a self-assembled arrangement consisting of hydrophilic block (GCS) and hydrophobic block (DEAP) at physiological pH. As the pH decreased to tumor extracellular pH (pHe), the nanogel was destabilized due to the protonation of DEAP. The pH-responsive property of the nanogel at tumor extracellular pH (pHe) was characterized in drug-release kinetic studies. The release of doxorubicin (DOX) from DOX-loaded nanogels was significantly accelerated at lower pH values, which allowed for increased DOX uptake by non-small lung carcinoma A546 cells under a slightly acidic pH condition, as in tumor pHe.

AB - In this study, a novel pH-responsive nanogel composed of glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups (denoted as GCS-g-DEAP hereafter) was fabricated. The GCS-g-DEAP was designed to have a self-assembled arrangement consisting of hydrophilic block (GCS) and hydrophobic block (DEAP) at physiological pH. As the pH decreased to tumor extracellular pH (pHe), the nanogel was destabilized due to the protonation of DEAP. The pH-responsive property of the nanogel at tumor extracellular pH (pHe) was characterized in drug-release kinetic studies. The release of doxorubicin (DOX) from DOX-loaded nanogels was significantly accelerated at lower pH values, which allowed for increased DOX uptake by non-small lung carcinoma A546 cells under a slightly acidic pH condition, as in tumor pHe.

KW - 3-Diethylaminopropyl

KW - Glycol chitosan

KW - PH-responsive nanogel

KW - Tumor extracellular pH

UR - https://www.scopus.com/pages/publications/77950626930

U2 - 10.1016/j.colsurfb.2010.02.023

DO - 10.1016/j.colsurfb.2010.02.023

M3 - Article

C2 - 20299192

AN - SCOPUS:77950626930

SN - 0927-7765

VL - 78

SP - 120

EP - 126

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

IS - 1

ER -

A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: In vitro evaluation

Abstract

UN SDGs

Keywords

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