A peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice

Young Suh Gee; Suk Ham Hyoung; Shin Hye Lee; Chul Choi Jae; Won Jung Koh; Soo Youl Kim; Jongmin Lee; Joungho Han; Pyo Kim Hong; Augustine M.K. Choi; Jung Kwon O

doi:10.1080/01902140600691514

A peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice

Young Suh Gee
, Suk Ham Hyoung
, Shin Hye Lee
, Chul Choi Jae
, Won Jung Koh
, Soo Youl Kim
, Jongmin Lee
, Joungho Han
, Pyo Kim Hong
, Augustine M.K. Choi
, Jung Kwon O

Department of Pathology and Translational Genomics

Sungkyunkwan University
Cornell University
University of Pittsburgh

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine mRNA expression in the lungs of LPS (25 mg/kg)-treated mice (P < .05). It also showed a tendency for decreased tumor necrosis factor (TNF)-α-immunoreactive protein in lung homogenates and significantly decreased TNF-α-immunoreactive protein in the serum of LPS-injected mice (P < .05). These results indicate that TGase may be a new therapeutic target in LPS-induced lung inflammation.

Original language	English
Pages (from-to)	43-53
Number of pages	11
Journal	Experimental Lung Research
Volume	32
Issue number	1-2
DOIs	https://doi.org/10.1080/01902140600691514
State	Published - Jan 2006

Keywords

Cytokine
Neutrophil
Phospholipase A

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10.1080/01902140600691514

Cite this

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title = "A peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice",

abstract = "Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine mRNA expression in the lungs of LPS (25 mg/kg)-treated mice (P < .05). It also showed a tendency for decreased tumor necrosis factor (TNF)-α-immunoreactive protein in lung homogenates and significantly decreased TNF-α-immunoreactive protein in the serum of LPS-injected mice (P < .05). These results indicate that TGase may be a new therapeutic target in LPS-induced lung inflammation.",

keywords = "Cytokine, Neutrophil, Phospholipase A",

author = "Gee, \{Young Suh\} and Hyoung, \{Suk Ham\} and Lee, \{Shin Hye\} and Jae, \{Chul Choi\} and Koh, \{Won Jung\} and Kim, \{Soo Youl\} and Jongmin Lee and Joungho Han and Hong, \{Pyo Kim\} and Choi, \{Augustine M.K.\} and O, \{Jung Kwon\}",

year = "2006",

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doi = "10.1080/01902140600691514",

language = "English",

volume = "32",

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journal = "Experimental Lung Research",

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TY - JOUR

T1 - A peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice

AU - Gee, Young Suh

AU - Hyoung, Suk Ham

AU - Lee, Shin Hye

AU - Jae, Chul Choi

AU - Koh, Won Jung

AU - Kim, Soo Youl

AU - Lee, Jongmin

AU - Han, Joungho

AU - Hong, Pyo Kim

AU - Choi, Augustine M.K.

AU - O, Jung Kwon

PY - 2006/1

Y1 - 2006/1

N2 - Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine mRNA expression in the lungs of LPS (25 mg/kg)-treated mice (P < .05). It also showed a tendency for decreased tumor necrosis factor (TNF)-α-immunoreactive protein in lung homogenates and significantly decreased TNF-α-immunoreactive protein in the serum of LPS-injected mice (P < .05). These results indicate that TGase may be a new therapeutic target in LPS-induced lung inflammation.

AB - Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine mRNA expression in the lungs of LPS (25 mg/kg)-treated mice (P < .05). It also showed a tendency for decreased tumor necrosis factor (TNF)-α-immunoreactive protein in lung homogenates and significantly decreased TNF-α-immunoreactive protein in the serum of LPS-injected mice (P < .05). These results indicate that TGase may be a new therapeutic target in LPS-induced lung inflammation.

KW - Cytokine

KW - Neutrophil

KW - Phospholipase A

UR - https://www.scopus.com/pages/publications/33646711922

U2 - 10.1080/01902140600691514

DO - 10.1080/01902140600691514

M3 - Article

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AN - SCOPUS:33646711922

SN - 0190-2148

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JO - Experimental Lung Research

JF - Experimental Lung Research

IS - 1-2

ER -

A peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice

Abstract

Keywords

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