A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)2 peptide delivery

Bo Reum Lee; Kyung Taek Oh; Young Taik Oh; Hye Jung Baik; So Young Park; Yu Seok Youn; Eun Seong Lee

doi:10.1039/c0cc03590d

A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)₂ peptide delivery

Bo Reum Lee, Kyung Taek Oh, Young Taik Oh, Hye Jung Baik, So Young Park, Yu Seok Youn, Eun Seong Lee

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as ‘GCS-g-DMA’ hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.

Original language	English
Pages (from-to)	3852-3854
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	13
DOIs	https://doi.org/10.1039/c0cc03590d
State	Published - 15 Mar 2011
Externally published	Yes

Access to Document

10.1039/c0cc03590d

Cite this

@article{8f10943620dd42858eb02eb247ded158,

title = "A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)2 peptide delivery",

abstract = "We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as {\textquoteleft}GCS-g-DMA{\textquoteright} hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.",

author = "Lee, \{Bo Reum\} and Oh, \{Kyung Taek\} and Oh, \{Young Taik\} and Baik, \{Hye Jung\} and Park, \{So Young\} and Youn, \{Yu Seok\} and Lee, \{Eun Seong\}",

year = "2011",

month = mar,

day = "15",

doi = "10.1039/c0cc03590d",

language = "English",

volume = "47",

pages = "3852--3854",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "13",

}

TY - JOUR

T1 - A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)2 peptide delivery

AU - Lee, Bo Reum

AU - Oh, Kyung Taek

AU - Oh, Young Taik

AU - Baik, Hye Jung

AU - Park, So Young

AU - Youn, Yu Seok

AU - Lee, Eun Seong

PY - 2011/3/15

Y1 - 2011/3/15

N2 - We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as ‘GCS-g-DMA’ hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.

AB - We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as ‘GCS-g-DMA’ hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.

UR - https://www.scopus.com/pages/publications/79952687474

U2 - 10.1039/c0cc03590d

DO - 10.1039/c0cc03590d

M3 - Article

C2 - 21321691

AN - SCOPUS:79952687474

SN - 1359-7345

VL - 47

SP - 3852

EP - 3854

JO - Chemical Communications

JF - Chemical Communications

IS - 13

ER -

A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)₂ peptide delivery

Abstract

Access to Document

Other files and links

Fingerprint

Cite this