A novel Bvar allele (547 G>A) demonstrates differential expression depending on the co-inherited ABO allele

D. Cho; S. H. Kim; C. S. Ki; K. L. Choi; Y. G. Cho; J. W. Song; J. H. Shin; S. P. Suh; M. H. Yazer; Dong Wook Ryang

doi:10.1111/j.1423-0410.2004.00575.x

A novel B_var allele (547 G>A) demonstrates differential expression depending on the co-inherited ABO allele

D. Cho
, S. H. Kim
, C. S. Ki
, K. L. Choi
, Y. G. Cho
, J. W. Song
, J. H. Shin
, S. P. Suh
, M. H. Yazer
, Dong Wook Ryang

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Background and Objectives: Genetic analysis of group B donors in Korea was performed. Materials and Methods: Exons 6 and 7 were sequenced in 12 phenotypically B₃ donors 6 B₃, 6 A₁B ₃. Results: Consensus sequences all B₃ and 2/6 A ₁B₃ donors were present. Four A₁B₃ donors demonstrated a novel B allele, B_var, in the context of A101/ or A102/B_var genotypes. Family studies based on an A ₁B₃ donor with the B_var allele and on another unrelated subject with identical genotype and phenotype revealed B _var/O01 genotypes with full B-antigen expression. Conclusions: B _var allele is subject to differential expression, depending on the coinherited ABO allele.

Original language	English
Pages (from-to)	187-189
Number of pages	3
Journal	Vox Sanguinis
Volume	87
Issue number	3
DOIs	https://doi.org/10.1111/j.1423-0410.2004.00575.x
State	Published - Oct 2004
Externally published	Yes

Keywords

ABO
Allele
Bvar
Genotype
Phenotype

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10.1111/j.1423-0410.2004.00575.x

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title = "A novel Bvar allele (547 G>A) demonstrates differential expression depending on the co-inherited ABO allele",

abstract = "Background and Objectives: Genetic analysis of group B donors in Korea was performed. Materials and Methods: Exons 6 and 7 were sequenced in 12 phenotypically B3 donors 6 B3, 6 A1B 3. Results: Consensus sequences all B3 and 2/6 A 1B3 donors were present. Four A1B3 donors demonstrated a novel B allele, Bvar, in the context of A101/ or A102/Bvar genotypes. Family studies based on an A 1B3 donor with the Bvar allele and on another unrelated subject with identical genotype and phenotype revealed B var/O01 genotypes with full B-antigen expression. Conclusions: B var allele is subject to differential expression, depending on the coinherited ABO allele.",

keywords = "ABO, Allele, Bvar, Genotype, Phenotype",

author = "D. Cho and Kim, \{S. H.\} and Ki, \{C. S.\} and Choi, \{K. L.\} and Cho, \{Y. G.\} and Song, \{J. W.\} and Shin, \{J. H.\} and Suh, \{S. P.\} and Yazer, \{M. H.\} and Ryang, \{Dong Wook\}",

year = "2004",

month = oct,

doi = "10.1111/j.1423-0410.2004.00575.x",

language = "English",

volume = "87",

pages = "187--189",

journal = "Vox Sanguinis",

issn = "0042-9007",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "3",

}

TY - JOUR

T1 - A novel Bvar allele (547 G>A) demonstrates differential expression depending on the co-inherited ABO allele

AU - Cho, D.

AU - Kim, S. H.

AU - Ki, C. S.

AU - Choi, K. L.

AU - Cho, Y. G.

AU - Song, J. W.

AU - Shin, J. H.

AU - Suh, S. P.

AU - Yazer, M. H.

AU - Ryang, Dong Wook

PY - 2004/10

Y1 - 2004/10

N2 - Background and Objectives: Genetic analysis of group B donors in Korea was performed. Materials and Methods: Exons 6 and 7 were sequenced in 12 phenotypically B3 donors 6 B3, 6 A1B 3. Results: Consensus sequences all B3 and 2/6 A 1B3 donors were present. Four A1B3 donors demonstrated a novel B allele, Bvar, in the context of A101/ or A102/Bvar genotypes. Family studies based on an A 1B3 donor with the Bvar allele and on another unrelated subject with identical genotype and phenotype revealed B var/O01 genotypes with full B-antigen expression. Conclusions: B var allele is subject to differential expression, depending on the coinherited ABO allele.

AB - Background and Objectives: Genetic analysis of group B donors in Korea was performed. Materials and Methods: Exons 6 and 7 were sequenced in 12 phenotypically B3 donors 6 B3, 6 A1B 3. Results: Consensus sequences all B3 and 2/6 A 1B3 donors were present. Four A1B3 donors demonstrated a novel B allele, Bvar, in the context of A101/ or A102/Bvar genotypes. Family studies based on an A 1B3 donor with the Bvar allele and on another unrelated subject with identical genotype and phenotype revealed B var/O01 genotypes with full B-antigen expression. Conclusions: B var allele is subject to differential expression, depending on the coinherited ABO allele.

KW - ABO

KW - Allele

KW - Bvar

KW - Genotype

KW - Phenotype

UR - https://www.scopus.com/pages/publications/7944231386

U2 - 10.1111/j.1423-0410.2004.00575.x

DO - 10.1111/j.1423-0410.2004.00575.x

M3 - Article

C2 - 15569071

AN - SCOPUS:7944231386

SN - 0042-9007

VL - 87

SP - 187

EP - 189

JO - Vox Sanguinis

JF - Vox Sanguinis

IS - 3

ER -

A novel B_var allele (547 G>A) demonstrates differential expression depending on the co-inherited ABO allele

Abstract

Keywords

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