A novel Bvar allele (547 G>A) demonstrates differential expression depending on the co-inherited ABO allele

D. Cho; S. H. Kim; C. S. Ki; K. L. Choi; Y. G. Cho; J. W. Song; J. H. Shin; S. P. Suh; M. H. Yazer; Dong Wook Ryang

doi:10.1111/j.1423-0410.2004.00575.x

A novel B_var allele (547 G>A) demonstrates differential expression depending on the co-inherited ABO allele

D. Cho, S. H. Kim, C. S. Ki, K. L. Choi, Y. G. Cho, J. W. Song, J. H. Shin, S. P. Suh, M. H. Yazer, Dong Wook Ryang

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Background and Objectives: Genetic analysis of group B donors in Korea was performed. Materials and Methods: Exons 6 and 7 were sequenced in 12 phenotypically B₃ donors 6 B₃, 6 A₁B ₃. Results: Consensus sequences all B₃ and 2/6 A ₁B₃ donors were present. Four A₁B₃ donors demonstrated a novel B allele, B_var, in the context of A101/ or A102/B_var genotypes. Family studies based on an A ₁B₃ donor with the B_var allele and on another unrelated subject with identical genotype and phenotype revealed B _var/O01 genotypes with full B-antigen expression. Conclusions: B _var allele is subject to differential expression, depending on the coinherited ABO allele.

Original language	English
Pages (from-to)	187-189
Number of pages	3
Journal	Vox Sanguinis
Volume	87
Issue number	3
DOIs	https://doi.org/10.1111/j.1423-0410.2004.00575.x
State	Published - Oct 2004
Externally published	Yes

Keywords

ABO
Allele
Bvar
Genotype
Phenotype

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10.1111/j.1423-0410.2004.00575.x

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title = "A novel Bvar allele (547 G>A) demonstrates differential expression depending on the co-inherited ABO allele",

abstract = "Background and Objectives: Genetic analysis of group B donors in Korea was performed. Materials and Methods: Exons 6 and 7 were sequenced in 12 phenotypically B3 donors 6 B3, 6 A1B 3. Results: Consensus sequences all B3 and 2/6 A 1B3 donors were present. Four A1B3 donors demonstrated a novel B allele, Bvar, in the context of A101/ or A102/Bvar genotypes. Family studies based on an A 1B3 donor with the Bvar allele and on another unrelated subject with identical genotype and phenotype revealed B var/O01 genotypes with full B-antigen expression. Conclusions: B var allele is subject to differential expression, depending on the coinherited ABO allele.",

keywords = "ABO, Allele, Bvar, Genotype, Phenotype",

author = "D. Cho and Kim, \{S. H.\} and Ki, \{C. S.\} and Choi, \{K. L.\} and Cho, \{Y. G.\} and Song, \{J. W.\} and Shin, \{J. H.\} and Suh, \{S. P.\} and Yazer, \{M. H.\} and Ryang, \{Dong Wook\}",

year = "2004",

month = oct,

doi = "10.1111/j.1423-0410.2004.00575.x",

language = "English",

volume = "87",

pages = "187--189",

journal = "Vox Sanguinis",

issn = "0042-9007",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "3",

}

TY - JOUR

T1 - A novel Bvar allele (547 G>A) demonstrates differential expression depending on the co-inherited ABO allele

AU - Cho, D.

AU - Kim, S. H.

AU - Ki, C. S.

AU - Choi, K. L.

AU - Cho, Y. G.

AU - Song, J. W.

AU - Shin, J. H.

AU - Suh, S. P.

AU - Yazer, M. H.

AU - Ryang, Dong Wook

PY - 2004/10

Y1 - 2004/10

N2 - Background and Objectives: Genetic analysis of group B donors in Korea was performed. Materials and Methods: Exons 6 and 7 were sequenced in 12 phenotypically B3 donors 6 B3, 6 A1B 3. Results: Consensus sequences all B3 and 2/6 A 1B3 donors were present. Four A1B3 donors demonstrated a novel B allele, Bvar, in the context of A101/ or A102/Bvar genotypes. Family studies based on an A 1B3 donor with the Bvar allele and on another unrelated subject with identical genotype and phenotype revealed B var/O01 genotypes with full B-antigen expression. Conclusions: B var allele is subject to differential expression, depending on the coinherited ABO allele.

AB - Background and Objectives: Genetic analysis of group B donors in Korea was performed. Materials and Methods: Exons 6 and 7 were sequenced in 12 phenotypically B3 donors 6 B3, 6 A1B 3. Results: Consensus sequences all B3 and 2/6 A 1B3 donors were present. Four A1B3 donors demonstrated a novel B allele, Bvar, in the context of A101/ or A102/Bvar genotypes. Family studies based on an A 1B3 donor with the Bvar allele and on another unrelated subject with identical genotype and phenotype revealed B var/O01 genotypes with full B-antigen expression. Conclusions: B var allele is subject to differential expression, depending on the coinherited ABO allele.

KW - ABO

KW - Allele

KW - Bvar

KW - Genotype

KW - Phenotype

UR - https://www.scopus.com/pages/publications/7944231386

U2 - 10.1111/j.1423-0410.2004.00575.x

DO - 10.1111/j.1423-0410.2004.00575.x

M3 - Article

C2 - 15569071

AN - SCOPUS:7944231386

SN - 0042-9007

VL - 87

SP - 187

EP - 189

JO - Vox Sanguinis

JF - Vox Sanguinis

IS - 3

ER -

A novel B_var allele (547 G>A) demonstrates differential expression depending on the co-inherited ABO allele

Abstract

Keywords

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