A new phenolic compound from salix glandulosa

Chung Sub Kim; Lalita Subedi; Joonseok Oh; Sun Yeou Kim; Sang Un Choi; Kang Ro Lee

doi:10.3987/COM-18-13892

A new phenolic compound from salix glandulosa

Chung Sub Kim
, Lalita Subedi
, Joonseok Oh
, Sun Yeou Kim
, Sang Un Choi
, Kang Ro Lee

Department of Pharmacy

Gachon University
Yale University
Korea Research Institute of Chemical Technology
Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A new phenolic compound, saliglandol (1), was isolated from Salix glandulosa along with 22 known ones. Their chemical structures were established through analyzing spectroscopic data. Comparison of calculated and experimental ECD spectra of 1 resulted in assignment of its absolute configuration. All isolated compounds (1–23) were evaluated for their cytotoxic activities against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, an BT549), anti-inflammatory effects measuring nitric oxide (NO) levels in lipopolysaccharide (LPS)-stimulated murine microglia BV2 cells, and potential neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells.

Original language	English
Pages (from-to)	931-942
Number of pages	12
Journal	Heterocycles
Volume	96
Issue number	5
DOIs	https://doi.org/10.3987/COM-18-13892
State	Published - 2018

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title = "A new phenolic compound from salix glandulosa",

abstract = "A new phenolic compound, saliglandol (1), was isolated from Salix glandulosa along with 22 known ones. Their chemical structures were established through analyzing spectroscopic data. Comparison of calculated and experimental ECD spectra of 1 resulted in assignment of its absolute configuration. All isolated compounds (1–23) were evaluated for their cytotoxic activities against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, an BT549), anti-inflammatory effects measuring nitric oxide (NO) levels in lipopolysaccharide (LPS)-stimulated murine microglia BV2 cells, and potential neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells.",

author = "Kim, \{Chung Sub\} and Lalita Subedi and Joonseok Oh and Kim, \{Sun Yeou\} and Choi, \{Sang Un\} and Lee, \{Kang Ro\}",

note = "Publisher Copyright: {\textcopyright} 2018 The Japan Institute of Heterocyclic Chemistry.",

year = "2018",

doi = "10.3987/COM-18-13892",

language = "English",

volume = "96",

pages = "931--942",

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T1 - A new phenolic compound from salix glandulosa

AU - Kim, Chung Sub

AU - Subedi, Lalita

AU - Oh, Joonseok

AU - Kim, Sun Yeou

AU - Choi, Sang Un

AU - Lee, Kang Ro

PY - 2018

Y1 - 2018

N2 - A new phenolic compound, saliglandol (1), was isolated from Salix glandulosa along with 22 known ones. Their chemical structures were established through analyzing spectroscopic data. Comparison of calculated and experimental ECD spectra of 1 resulted in assignment of its absolute configuration. All isolated compounds (1–23) were evaluated for their cytotoxic activities against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, an BT549), anti-inflammatory effects measuring nitric oxide (NO) levels in lipopolysaccharide (LPS)-stimulated murine microglia BV2 cells, and potential neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells.

AB - A new phenolic compound, saliglandol (1), was isolated from Salix glandulosa along with 22 known ones. Their chemical structures were established through analyzing spectroscopic data. Comparison of calculated and experimental ECD spectra of 1 resulted in assignment of its absolute configuration. All isolated compounds (1–23) were evaluated for their cytotoxic activities against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, an BT549), anti-inflammatory effects measuring nitric oxide (NO) levels in lipopolysaccharide (LPS)-stimulated murine microglia BV2 cells, and potential neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells.

UR - https://www.scopus.com/pages/publications/85047904924

U2 - 10.3987/COM-18-13892

DO - 10.3987/COM-18-13892

M3 - Article

AN - SCOPUS:85047904924

SN - 0385-5414

VL - 96

SP - 931

EP - 942

JO - Heterocycles

JF - Heterocycles

IS - 5

ER -

A new phenolic compound from salix glandulosa

Abstract

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