TY - GEN
T1 - A new perspective of integrative genome-wide association analysis considering trans eSNP effect
AU - Kim, Junho
AU - Lee, Doheon
PY - 2010
Y1 - 2010
N2 - Most loci discovered through genome-wide association analyses are predicted to affect gene expression, the integrative approach of genome-wide analysis with gene expression data is becoming essential procedure for discovering genetic effect of disease development. Many studies have been performed to discover significant SNP-gene associations, but most of them are limited to consider only cis-associations and neglect trans-territory. In this study, we explored the effect of trans-eSNP associations that may underlie the alternation of gene expressions. Through the integrative genome-wide association analysis considering the entire SNP-gene associations, we identified numerous trans associations which are significantly associated with gene expression, even more than cis associations in quantity and significance. Our findings revealed the necessity of reconsidering trans-association effect from integrative genome-wide association analysis and provided novel insights to find undiscovered genetic causalities.
AB - Most loci discovered through genome-wide association analyses are predicted to affect gene expression, the integrative approach of genome-wide analysis with gene expression data is becoming essential procedure for discovering genetic effect of disease development. Many studies have been performed to discover significant SNP-gene associations, but most of them are limited to consider only cis-associations and neglect trans-territory. In this study, we explored the effect of trans-eSNP associations that may underlie the alternation of gene expressions. Through the integrative genome-wide association analysis considering the entire SNP-gene associations, we identified numerous trans associations which are significantly associated with gene expression, even more than cis associations in quantity and significance. Our findings revealed the necessity of reconsidering trans-association effect from integrative genome-wide association analysis and provided novel insights to find undiscovered genetic causalities.
KW - Integrative GWAS
KW - Trans eSNP
UR - https://www.scopus.com/pages/publications/79952415177
U2 - 10.1109/BIBM.2010.5706543
DO - 10.1109/BIBM.2010.5706543
M3 - Conference contribution
AN - SCOPUS:79952415177
SN - 9781424483075
T3 - Proceedings - 2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010
SP - 91
EP - 94
BT - Proceedings - 2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010
T2 - 2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010
Y2 - 18 December 2010 through 21 December 2010
ER -