A new monoacylglycerol from the fruiting bodies of gymnopilus spectabilis

Won Se Suh; Seoung Rak Lee; Chung Sub Kim; Eunjung Moon; Sun Yeou Kim; Sang Un Choi; Ki Sung Kang; Kang Ro Lee; Ki Hyun Kim

doi:10.3184/174751916X14546877525997

A new monoacylglycerol from the fruiting bodies of gymnopilus spectabilis

Won Se Suh, Seoung Rak Lee, Chung Sub Kim, Eunjung Moon, Sun Yeou Kim, Sang Un Choi, Ki Sung Kang, Kang Ro Lee, Ki Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Bioassay-guided fractionation and chemical investigation of the MeOH extract of the wild mushroom Gymnopilus spectabilis resulted in the isolation of a new monoacylglycerol, together with five known compounds. The structure of the new compound (2'S)-1-O-(6,6-dimethoxyhexanol)-glycerol was elucidated on the basis of 1D and 2D NMR (¹H and ¹³C NMR, ¹H-¹H COSY, HMQC and HMBC) spectroscopic data as well as chemical reactions. The known compounds were identified by comparison of their spectroscopic and physical data with the reported values. The metabolites were evaluated for their anti-proliferative activities against four human tumour cell lines (A549, SK-OV-3, SK-MEL-2 and HCT-15) and for their inhibitory effects on nitric oxide production in lipopolysaccharide (LPS)-activated murine microglial cells.

Original language	English
Pages (from-to)	156-159
Number of pages	4
Journal	Journal of Chemical Research
Volume	40
Issue number	3
DOIs	https://doi.org/10.3184/174751916X14546877525997
State	Published - Mar 2016

Keywords

Cortinariaceae
Cytotoxicity
Gymnopilus spectabilis
Monoacylglycerol
NO

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10.3184/174751916X14546877525997

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title = "A new monoacylglycerol from the fruiting bodies of gymnopilus spectabilis",

abstract = "Bioassay-guided fractionation and chemical investigation of the MeOH extract of the wild mushroom Gymnopilus spectabilis resulted in the isolation of a new monoacylglycerol, together with five known compounds. The structure of the new compound (2'S)-1-O-(6,6-dimethoxyhexanol)-glycerol was elucidated on the basis of 1D and 2D NMR (1H and 13C NMR, 1H-1H COSY, HMQC and HMBC) spectroscopic data as well as chemical reactions. The known compounds were identified by comparison of their spectroscopic and physical data with the reported values. The metabolites were evaluated for their anti-proliferative activities against four human tumour cell lines (A549, SK-OV-3, SK-MEL-2 and HCT-15) and for their inhibitory effects on nitric oxide production in lipopolysaccharide (LPS)-activated murine microglial cells.",

keywords = "Cortinariaceae, Cytotoxicity, Gymnopilus spectabilis, Monoacylglycerol, NO",

author = "Suh, \{Won Se\} and Lee, \{Seoung Rak\} and Kim, \{Chung Sub\} and Eunjung Moon and Kim, \{Sun Yeou\} and Choi, \{Sang Un\} and Kang, \{Ki Sung\} and Lee, \{Kang Ro\} and Kim, \{Ki Hyun\}",

year = "2016",

month = mar,

doi = "10.3184/174751916X14546877525997",

language = "English",

volume = "40",

pages = "156--159",

journal = "Journal of Chemical Research",

issn = "1747-5198",

publisher = "Science Reviews Ltd",

number = "3",

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T1 - A new monoacylglycerol from the fruiting bodies of gymnopilus spectabilis

AU - Suh, Won Se

AU - Lee, Seoung Rak

AU - Kim, Chung Sub

AU - Moon, Eunjung

AU - Kim, Sun Yeou

AU - Choi, Sang Un

AU - Kang, Ki Sung

AU - Lee, Kang Ro

AU - Kim, Ki Hyun

PY - 2016/3

Y1 - 2016/3

N2 - Bioassay-guided fractionation and chemical investigation of the MeOH extract of the wild mushroom Gymnopilus spectabilis resulted in the isolation of a new monoacylglycerol, together with five known compounds. The structure of the new compound (2'S)-1-O-(6,6-dimethoxyhexanol)-glycerol was elucidated on the basis of 1D and 2D NMR (1H and 13C NMR, 1H-1H COSY, HMQC and HMBC) spectroscopic data as well as chemical reactions. The known compounds were identified by comparison of their spectroscopic and physical data with the reported values. The metabolites were evaluated for their anti-proliferative activities against four human tumour cell lines (A549, SK-OV-3, SK-MEL-2 and HCT-15) and for their inhibitory effects on nitric oxide production in lipopolysaccharide (LPS)-activated murine microglial cells.

AB - Bioassay-guided fractionation and chemical investigation of the MeOH extract of the wild mushroom Gymnopilus spectabilis resulted in the isolation of a new monoacylglycerol, together with five known compounds. The structure of the new compound (2'S)-1-O-(6,6-dimethoxyhexanol)-glycerol was elucidated on the basis of 1D and 2D NMR (1H and 13C NMR, 1H-1H COSY, HMQC and HMBC) spectroscopic data as well as chemical reactions. The known compounds were identified by comparison of their spectroscopic and physical data with the reported values. The metabolites were evaluated for their anti-proliferative activities against four human tumour cell lines (A549, SK-OV-3, SK-MEL-2 and HCT-15) and for their inhibitory effects on nitric oxide production in lipopolysaccharide (LPS)-activated murine microglial cells.

KW - Cortinariaceae

KW - Cytotoxicity

KW - Gymnopilus spectabilis

KW - Monoacylglycerol

KW - NO

UR - https://www.scopus.com/pages/publications/84962815504

U2 - 10.3184/174751916X14546877525997

DO - 10.3184/174751916X14546877525997

M3 - Article

AN - SCOPUS:84962815504

SN - 1747-5198

VL - 40

SP - 156

EP - 159

JO - Journal of Chemical Research

JF - Journal of Chemical Research

IS - 3

ER -

A new monoacylglycerol from the fruiting bodies of gymnopilus spectabilis

Abstract

Keywords

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