Abstract
A new cyclic triterpene saponin, phyteujaposide (1) and eight known compounds (2-9) were isolated from the leaves of Phyteuma japonicum. The structure of the new compound (1) was elucidated by 1D and 2D data analysis, acid hydrolysis and GC-MS. Compounds 7 and 9 potently inhibited the NO production in LPS-activated BV-2 cells and compounds 5 and 6 showed a significant secretion induction of NGF in C6 glioma without cell toxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 1913-1922 |
| Number of pages | 10 |
| Journal | Heterocycles |
| Volume | 89 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2014 |