Abstract
This paper presents a microfluidic model for studying the sequential steps of the cancer extravasation process, in which cancer cells exit capillaries and enter organs. We demonstrate the functionality of this model by co-culturing and observing the adhesion of SK-Mel-28 (Malignant Melanoma) cells to a Human Umbilical Vein Endothelial Cell (HUVEC) monolayer, followed by their migration through this HUVEC layer into gelatin-filled microgaps.
| Original language | English |
|---|---|
| Title of host publication | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 |
| Pages | 650-652 |
| Number of pages | 3 |
| State | Published - 2010 |
| Externally published | Yes |
| Event | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands Duration: 3 Oct 2010 → 7 Oct 2010 |
Publication series
| Name | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 |
|---|---|
| Volume | 1 |
Conference
| Conference | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 |
|---|---|
| Country/Territory | Netherlands |
| City | Groningen |
| Period | 3/10/10 → 7/10/10 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- 3-D co-culture
- Adhesion
- Endothelial cells
- Metastatic cascade
- Migration
- Monolayer
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