A hyaluronic acid–methotrexate conjugate for targeted therapy of rheumatoid arthritis

Jung Min Shin; Seol Hee Kim; Thavasyappan Thambi; Dong Gil You; Jueun Jeon; Jong Oh Lee; Bong Youl Chung; Dong Gyu Jo; Jae Hyung Park

doi:10.1039/c4cc02595d

A hyaluronic acid–methotrexate conjugate for targeted therapy of rheumatoid arthritis

Jung Min Shin
, Seol Hee Kim
, Thavasyappan Thambi
, Dong Gil You
, Jueun Jeon
, Jong Oh Lee
, Bong Youl Chung
, Dong Gyu Jo
, Jae Hyung Park

Sungkyunkwan University
Korea Research Institute of Standards and Science
Humedix, Co. Ltd.

Research output: Contribution to journal › Article › peer-review

127 Scopus citations

Abstract

In an effort to improve the therapeutic efficacy of methotrexate (MTX), we prepared the hyaluronic acid–MTX conjugate for targeted therapy of rheumatoid arthritis (RA). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released under the mildly acidic conditions, similar to the environment of inflamed synovial tissue in RA.

Original language	English
Pages (from-to)	7632-7635
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	57
DOIs	https://doi.org/10.1039/c4cc02595d
State	Published - 19 Jun 2014

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title = "A hyaluronic acid–methotrexate conjugate for targeted therapy of rheumatoid arthritis",

abstract = "In an effort to improve the therapeutic efficacy of methotrexate (MTX), we prepared the hyaluronic acid–MTX conjugate for targeted therapy of rheumatoid arthritis (RA). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released under the mildly acidic conditions, similar to the environment of inflamed synovial tissue in RA.",

author = "Shin, \{Jung Min\} and Kim, \{Seol Hee\} and Thavasyappan Thambi and You, \{Dong Gil\} and Jueun Jeon and Lee, \{Jong Oh\} and Chung, \{Bong Youl\} and Jo, \{Dong Gyu\} and Park, \{Jae Hyung\}",

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T1 - A hyaluronic acid–methotrexate conjugate for targeted therapy of rheumatoid arthritis

AU - Shin, Jung Min

AU - Kim, Seol Hee

AU - Thambi, Thavasyappan

AU - You, Dong Gil

AU - Jeon, Jueun

AU - Lee, Jong Oh

AU - Chung, Bong Youl

AU - Jo, Dong Gyu

AU - Park, Jae Hyung

PY - 2014/6/19

Y1 - 2014/6/19

N2 - In an effort to improve the therapeutic efficacy of methotrexate (MTX), we prepared the hyaluronic acid–MTX conjugate for targeted therapy of rheumatoid arthritis (RA). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released under the mildly acidic conditions, similar to the environment of inflamed synovial tissue in RA.

AB - In an effort to improve the therapeutic efficacy of methotrexate (MTX), we prepared the hyaluronic acid–MTX conjugate for targeted therapy of rheumatoid arthritis (RA). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released under the mildly acidic conditions, similar to the environment of inflamed synovial tissue in RA.

UR - https://www.scopus.com/pages/publications/84903162955

U2 - 10.1039/c4cc02595d

DO - 10.1039/c4cc02595d

M3 - Article

C2 - 24893961

AN - SCOPUS:84903162955

SN - 1359-7345

VL - 50

SP - 7632

EP - 7635

JO - Chemical Communications

JF - Chemical Communications

IS - 57

ER -

A hyaluronic acid–methotrexate conjugate for targeted therapy of rheumatoid arthritis

Abstract

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